Results 111 to 120 of about 34,807 (281)
JPGN Reports, EarlyView.Abstract Thiopurines, such as azathioprine (AZA), are among the immunosuppressants used to prevent allograft rejection. Thiopurines are metabolized by thiopurine S‐methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) enzymes, and their functions are highly influenced by genetic variation. We present a 6‐year‐old female with recurrent acute cellular
Jenny Q. Nguyen +4 more
wiley +1 more source
Respondents’ educational format preferences in pharmacogenetics.
, 2018 Respondents’ educational format preferences in pharmacogenetics.
Abdullah Albassam (5721110) +4 more
core +1 more source
Cross‐Cohort Evidence Links KCNJ6 rs702859 to Impulsive–Compulsive Phenotypes in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Impulse control disorders (ICDs) and related compulsive behaviors (CBs) are frequent non‐motor complications of Parkinson's disease (PD) with a probable genetic contribution. Objective To investigate whether genetic variants involved in reward and punishment processing are associated with impulsive–compulsive phenotypes in PD ...
Sergio García‐Díaz +21 more
wiley +1 more source
Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria
Nature CommunicationsErythropoietic protoporphyria (EPP) is a genetic disease characterized by protoporphyrin IX-mediated painful phototoxicity. Currently, options for the management of EPP-associated phototoxicity are limited and no oral medication is available.
Junjie Zhu +8 more
doaj +1 more source
Pharmacogenetics in advanced Parkinson’s disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a wide variety of symptoms and evolution. In addition, the response to antiparkinsonian medication is not predictable, especially for those patients with advanced PD ...
Kulisevsky Jaime +21 more
core +4 more sources
Nature CommunicationsSERPINB9, an endogenous inhibitor of granzyme B (GzmB), has emerged as a critical factor in the resistance to immunotherapy by protecting cancer cells from GzmB-induced cytotoxicity. However, its role in chemosensitivity remains unknown.
Haozhe Huang +15 more
doaj +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Objective To assess the efficacy and safety of transplacental flecainide and/or digoxin for fetal tachyarrhythmias when sotalol is unavailable. Method We evaluated transplacental flecainide, digoxin, or combination therapy in a retrospective and prospective cohort across two Thai tertiary centers.
Mukpradab Darakamas +6 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit +5 more
wiley +1 more source
Pharmacogenetics of tamoxifen in breast cancer patients of African descent: Lack of data
Clinical and Translational ScienceTamoxifen, a selective estrogen receptor modulator, is used to treat hormone receptor‐positive breast cancer. Tamoxifen acts as a prodrug, with its primary therapeutic effect mediated by its principal metabolite, endoxifen. However, tamoxifen has complex
Bianca Kruger +3 more
doaj +1 more source
Archives of Medical ScienceIntroduction The present study concerns a connection of the Q192RPON1 polymorphism with atherosclerosis requiring percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the Polish population.
Malgorzata Baranska +4 more
doaj +1 more source