Results 131 to 140 of about 30,618 (276)
Pharmacogenetics and ethical considerations: why care?
, 2007 http://dx.doi.org/10.1038/sj.tpj ...
Marx-Stölting, L.
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen +5 more
wiley +1 more source
Pharmacogenetic Factors Shaping Treatment Outcomes in Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) manifests as a genetically diverse and intricate lung condition with various subtypes. The development of the disease and response to treatment are influenced by the interplay between genetic and environmental
Charikleia Ntenti +2 more
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Pharmacogenetics and clinical gastroenterology
, 2003 Many drugs exhibit variable efficacy and toxicity. Pharmacogenetics explores the genetic underpinnings of variable drug response. Pharmacogenetic testing is beginning to enter the clinic and will have a significant impact on the practice of clinical ...
Givens, Raymond C., Watkins, Paul B.
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Hepatology Research, EarlyView.ABSTRACT Aim Genetic polymorphisms of alcohol‐metabolizing enzymes influence drinking behavior and susceptibility to alcohol‐related liver disease (ALD). This study aimed to clarify the distribution of ALDH2 and ADH1B genotypes in liver transplant recipients with ALD, and to explore associations with post‐transplant drinking behavior using a recipient ...
Noriyo Yamashiki +3 more
wiley +1 more source
Ethical issues in pharmacogenetics
, 2010 Pharmacogenetics has been heralded as a new discipline that can significantly improve drug efficacy and limit toxicity. This would advocate its rapid adoption into clinical practice.
Tara Clancy, Clancy, Tara
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Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source