Results 131 to 140 of about 34,807 (281)
Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia
BMC PsychiatryBackground Clinical and genetic studies have suggested that immune dysregulation and neuroinflammation are involved in the pathogenesis of schizophrenia.
Héctor Cabello-Rangel +5 more
doaj +1 more source
CARDIOVASCULAR PHARMACOGENETICS
, 2006 A variabilidade de resposta à droga entre pacientes é parcialmente devida à composição genética única que cada indivíduos apresenta. O ramo da Farmacologia Clínica que estuda tais variabilidades é chamado de farmacogenética. Variações genéticas (chamadas
Rezende, Vânia B. +2 more
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley +1 more source
Oral Diseases, EarlyView.ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto +3 more
wiley +1 more source
Building a precision therapeutics program at a tertiary care children's hospital
Pediatric Investigation, EarlyView.
Luke Hamilton +8 more
wiley +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity
Acta Pharmaceutica Sinica BOne of the leading therapies for acute lymphoblastic leukemia (ALL) is the chemotherapeutic agent PEGylated E. coli-derived-l-asparaginase (PEG-ASNase).
Yin Zhu +7 more
doaj +1 more source
Third Space Endoscopic Therapies for Benign Motility Disorders: A Narrative Review
DEN Open, Volume 7, Issue 1, April 2027.ABSTRACT Objectives To review the evidence base, evolution, outcomes, adverse events (AEs), and management for third‐space endoscopy (TSE) procedures for management of benign motility disorders. Methods This review examines TSE procedures for motility disorders, reviewing the current available techniques, success, outcomes, and long‐term outcomes from ...
Sanjana Bhagwat, Amol Bapaye
wiley +1 more source
Pharmacogenetics and the Blood–Brain Barrier: A Whirlwind Tour of Potential Clinical Utility
Future PharmacologyGenetic factors influence medication response (pharmacogenetics), affecting the pharmacodynamics and pharmacokinetics of many medicaments used in clinical care.
David R. Skvarc +5 more
doaj +1 more source
Warfarin Pharmacogenetics: Economic Considerations
Economic-implications, Pharmacogenetics, Thromboembolism ...
Dyfrig A. Hughes, Munir Pirmohamed
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