Results 141 to 150 of about 34,807 (281)

Respondents’ perceptions towards pharmacogenetics and its implications (n = 617).

, 2018
Respondents’ perceptions towards pharmacogenetics and its implications (n = 617).
Abdullah Albassam (5721110), Abdelmoneim Awad (5721122), Samuel Koshy (5721119), Shahad Alshammari (5721113), Ghadeer Ouda (5721116)   +4 more
core   +1 more source

Dose‐dependent efficacy and safety of centanafadine in patients with attention‐deficit/hyperactivity disorder: A systematic review of the latest evidence

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Centanafadine is a multimodal norepinephrine–dopamine–serotonin reuptake inhibitor (NDSRI) that has been evaluated for the treatment of attention‐deficit/hyperactivity disorder (ADHD) across pediatric, adolescent, and adult populations. This systematic review aimed to evaluate the efficacy, safety, and tolerability of centanafadine compared ...
Daud Gul, Sonia Khan, Kushal Baral, Ziad Saber, Arindam Ghosh, Eemaz Nathaniel, Onuwabhagbe Daniel Omomhenle, Nathaniel Oluwakayode Oyedeji, Lana Omar Saed Alkhatib, Lina Jamal Amin Sa'doun, Austin Nwawueze, Muhammad Naveed Ullah Khan, Raouf Khan   +12 more
wiley   +1 more source

Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy

Nature Communications
The multifaceted chemo-immune resistance is the principal barrier to achieving cure in cancer patients. Identifying a target that is critically involved in chemo-immune-resistance represents an attractive strategy to improve cancer treatment.
Zhangyi Luo, Yixian Huang, Neelu Batra, Yuang Chen, Haozhe Huang, Yifei Wang, Ziqian Zhang, Shichen Li, Chien-Yu Chen, Zehua Wang, Jingjing Sun, Qiming Jane Wang, Da Yang, Binfeng Lu, James F. Conway, Lu-Yuan Li, Ai-Ming Yu, Song Li   +17 more
doaj   +1 more source

CCR1 Antagonism by BX471 Attenuates Neuroinflammation and Apoptosis: Preliminary Findings From an In Vitro Model of Neuronal Injury

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Neuronal injury as traumatic brain injury (TBI) triggers a complex pathophysiological cascade involving inflammatory and apoptosis processes. BX471 is a selective C‐C chemokine receptor type 1 (CCR1) antagonist that showed a promising effect in modulating neuroinflammation in central nervous system (CNS) disorders.
Ahmed Hasan, Deborah Mannino, Sarah Adriana Scuderi, Lucia Buccarello, Emanuela Esposito, Giuseppe Caruso, Alessio Ardizzone   +6 more
wiley   +1 more source

Biological, Environmental, and Social Determinants of Buruli Ulcer in Africa: Their Interplay Across Disease Severity and Patient Outcome

Public Health Challenges, Volume 5, Issue 4, December 2026.
Buruli ulcer is caused by Mycobacterium ulcerans and its toxin, mycolactone. Disease outcomes are influenced by biological, environmental, and social determinants. Biological factors include immune response and lesion severity. Environmental factors include aquatic exposure, rainfall, flooding, and ecological changes.
Gudisa Bereda
wiley   +1 more source

Hormonal Therapy Before Micro‐TESE in Men With Nonobstructive Azoospermia: A Negative Answer to an Overly Broad Question

Andrology, EarlyView.
Sandro C. Esteves, Arnold P. P. Achermann, Ricardo Miyaoka, Cassio L. Z. Riccetto, Adriano Fregonesi   +4 more
wiley   +1 more source

DPYD and UGT1A1 Genotype‐Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant‐Specific Impact on Treatment Intensity and Toxicity

International Journal of Cancer, Volume 159, Issue 10, Page 2512-2524, 15 November 2026.
Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron, Elena Peruzzi, Samantha Perfler, Marcella Montico, Riccardo Cecchin, Elena De Mattia, Michele Spina, Camilla Lisanti, Serena Corsetti, Luisa Foltran, Fabio Puglisi, Rossana Roncato, Erika Cecchin   +12 more
wiley   +1 more source

Pharmacogenetic Factors Shaping Treatment Outcomes in Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) manifests as a genetically diverse and intricate lung condition with various subtypes. The development of the disease and response to treatment are influenced by the interplay between genetic and environmental
Charikleia Ntenti, Thomas Nikos Misirlis, Antonis Goulas   +2 more
core   +1 more source

Author's Response: Can Hormonal Therapy Improve the Outcomes of mTESE in Patients with Nonobstructive Azoospermia?

Andrology, EarlyView.
M. Anfosso, M. Schubert, JF. Cremers, S. Kliesch, M. Zitzmann, S. Bier   +5 more
wiley   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, Volume 78, Issue 11, Page 1618-1630, November 2026.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source