Results 141 to 150 of about 57,996 (259)

Japanese Cohort Study Identifies an Association Between the Serotonin Transporter–Linked Polymorphic Region and Suicide Death

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
The odds ratios and corresponding 95% confidence intervals for suicide death by 5‐HTTLPR S allele, in main and subgroup analyses. Statistical significance is indicated. ABSTRACT Introduction More than 720 000 individuals die by suicide annually worldwide, making it a major public health concern and a leading cause of death among young people ...
Shohei Okada, Toshiyuki Shirai, Masao Miyachi, Gentaro Yamasaki, Kiriko Minami, Ryo Tsukamoto, Kentaro Mouri, Takaki Tanifuji, Ryuichi Katada, Satoshi Okazaki, Ikuo Otsuka, Akitoyo Hishimoto   +11 more
wiley   +1 more source

The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model

Hepatology Communications
Background:. The prevalence of NAFLD is rapidly increasing. NAFLD can progress to NASH, fibrosis, cirrhosis, and HCC, which will soon become the main causes of liver transplantation.
Sander van Riet, Anais Julien, Andrea Atanasov, Åsa Nordling, Magnus Ingelman-Sundberg   +4 more
doaj   +1 more source

Subgroup Identification via Multiple Change Point Detection: Methods and Applications

WIREs Computational Statistics, Volume 18, Issue 2, June 2026.
Subgroup identification methods facilitate the discovery of clinically meaningful subpopulations with differing disease progression, improving personalized risk assessment and treatment strategies. ABSTRACT Subgroup identification is a significant research area in statistics and machine learning, aiming to partition a heterogeneous population into more
Yaguang Li, Jingli Wang, Da Zhao, Jialiang Li   +3 more
wiley   +1 more source

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1438-1444, May 2026.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

Antidepressant Pharmacogenetics [PDF]

American Journal of Psychiatry, 2017
Ajeet B, Singh, Chad A, Bousman
openaire   +2 more sources

APOE genotype and the effect of statins on lipid outcomes: A meta‐analysis

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1268-1286, May 2026.
Aim APOE genotype may affect statin therapy response. We conducted a meta‐analysis to update and quantify this association across various outcomes. Methods We searched seven databases (MEDLINE, Scopus, Web of Science, the Cochrane Library, APA PsycINFO, CINAHL Plus and ClinicalTrials.gov) on 9 May 2024.
Innocent G. Asiimwe, Tsegay Gebru, Andrea L. Jorgensen, Munir Pirmohamed, on behalf of the Multimorbidity Mechanism and Therapeutics Research Collaborative   +4 more
wiley   +1 more source

Initial assessment of the benefits of implementing pharmacogenetics into the medical management of patients in a long-term care facility

Pharmacogenomics and Personalized Medicine, 2016
Juan-Sebastian Saldivar, David Taylor, Elaine A Sugarman, Ali Cullors, Jorge A Garces, Kahuku Oades, Joel Centeno AltheaDx, San Diego, CA, USA Abstract: The health care costs associated with prescription drugs are enormous, particularly in patients with ...
Saldivar JS, Taylor D, Sugarman EA, Cullors A, Garces JA, Oades K, Centeno J   +6 more
doaj  

Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients

Molecular Medicine
Background Patient-derived xenograft (PDX) is currently considered a preferred preclinical model to evaluate drug sensitivity, explore drug resistance mechanisms, and select individualized treatment regimens.
Xiaoqing Wang, Ju Zhu, Lingling Li, Qilin Zhao, Yutang Huang, Chunjie Wen, Dan Chen, Lanxiang Wu   +7 more
doaj   +1 more source

PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1235-1248, May 2026.
Model‐informed drug development is increasingly integrated across the drug development continuum, enabling more efficient, cost‐effective, and targeted trials while reducing reliance on animal studies. Achieving pharmacoequity requires not only equitable access to medicines but also to the data and knowledge that inform drug development and regulatory ...
Shakir Atoyebi, Prajith Venkatasubramanian, Abdulafeez Akinloye, Oluwasegun Eniayewu, Brookie M. Best, Laura Else, Adeniyi Olagunju   +6 more
wiley   +1 more source

Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT An important mechanism controlling protein synthesis is through phosphorylation of the eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K. Hyperphosphorylation of eEF2 is linked to many neuronal diseases characterized by cognitive impairments.
Qian Yang, Tian Li, Hannah M. Jester, Qiang Su, Xueyan Zhou, Alexey G. Ryazanov, Tao Ma   +6 more
wiley   +1 more source