Results 161 to 170 of about 46,119 (273)

Integrating CRISPR functional genomics with admixture-aware psychotropic pharmacogenetics in Brazil. [PDF]

Front Pharmacol
Rodrigues BB, Bittencourt JC, Dos Santos VGM, Costamilan CADVL, Herkenhoff ME.   +4 more
europepmc   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, Volume 183, Issue 16, Page 4735-4760, August 2026.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Limited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature. [PDF]

Clin Transl Sci
Dello Russo C, Venetucci L, Akintola A, Gagliardi D, Ramlogan R, Pirmohamed M.   +5 more
europepmc   +1 more source

Liquid Chromatography–Tandem Mass Spectrometry Quantification of Diet‐Derived CYP2D6 Biomarkers for Clinical Phenotyping in Japanese Subjects

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The enzymatic activity of cytochrome P450 2D6 (CYP2D6) exhibits substantial interindividual variation, which influences drug efficacy and the risk of adverse drug reactions to various therapeutics. While current protocols for CYP2D6 genotyping or CYP2D6 phenotyping provide useful information, less invasive and simpler tools are desirable for ...
Masaki Kumondai, Nagomi Hayashi, Yotaro Matsumoto, Akiko Ebata, Miku Sato, Narumi Harada‐Shoji, Hiroshi Tada, Minoru Miyashita, Takanori Ishida, Masamitsu Maekawa, Yoshihisa Tomioka, Nariyasu Mano   +11 more
wiley   +1 more source

Genetic Landscape of NAT2 in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The NAT2 gene encodes N‐acetyltransferase 2, an enzyme critically involved in the biotransformation of numerous xenobiotics and aromatic amines, including isoniazid, a cornerstone drug in tuberculosis therapy. Genetic polymorphisms in NAT2 lead to variable acetylation rates, clinically categorized as poor, intermediate, or rapid metabolizer ...
Nada Benyahya, Mohsine‐Ali El‐Hamri, Jaber Lyahyai, Ilham Ratbi, Imane Cherkaoui, Zineb Rchiad, Abdelaziz Sefiani   +6 more
wiley   +1 more source

Pharmacogenetics in Community Pharmacy: Global Perspectives and Implementation. [PDF]

J Clin Med
Rutkowska K, Chełstowska B, Religioni U, Borowska M, Kobayashi A, Vaillancourt R, Białoszewski A, Sikorski S, Doniec Z, Bromber P, Biala A, Kurek K, Pawlikowski J, Merks P.   +13 more
europepmc   +1 more source

CYP2C19 c.681G>A Is not in Complete Linkage Disequilibrium With c.332‐23A>G: Implications for Pharmacogenetic Testing

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT CYP2C19 plays an important role in the metabolism of many medications, including the antiplatelet agent clopidogrel, the antifungal agent voriconazole, selective serotonin reuptake inhibitors, select tricyclic antidepressants, and proton pump inhibitors.
Amy J. Turner, Erin C. Boone, Cyrine E. Haidar, Wenjian Yang, Ashley D. Derezinski, Andrew Haddad, Philip E. Empey, Ulrich Broeckel, Andrea Gaedigk   +8 more
wiley   +1 more source

Genotyping of DPYD and UGT1A1 in Brazilian oncological patients: applying pharmacogenomics in an admixed population. [PDF]

Rev Assoc Med Bras (1992)
Cereser VHB, Moniz CMV, Suarez-Kurtz G, Estevez-Diz MDP.   +3 more
europepmc   +1 more source

Psychotropic pharmacogenetics [PDF]

Australian & New Zealand Journal of Psychiatry, 2016
openaire   +2 more sources

Involvement of persons with lived experience in mental health research: recommendations. [PDF]

Neurosci Appl
Kleine Schaars K, Young AH, Moldovan R, Van der Eycken E, Schuster F, Klopper J, Heilbronner U, Kas MJH, PSY-PGx Consortium, van Westrhenen R.   +9 more
europepmc   +1 more source