Results 171 to 180 of about 30,618 (276)

The Role of Pharmacogenetics in the Effectiveness of Rheumatoid Arthritis Treatment with Leflunomide. [PDF]

Genes (Basel)
Plewa P, Jędrasiak A, Jerzyńska O, Dach A, Domańska M, Pawlik A.   +5 more
europepmc   +1 more source

Impact of FCGR2A and FCGR3A Gene Variants on the Response to Rituximab in Patients With Glomerular Diseases

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Rituximab is an anti‐CD20 monoclonal antibody used in autoimmune diseases, including glomerular diseases. The FCGR2A (rs1801274) and FCGR3A (rs396991) variants have been suggested to affect rituximab efficacy; this study evaluates their impact on rituximab efficacy in glomerular diseases.
María Larrosa‐García, Irene Agraz Pamplona, Susana Rojo Tolosa, Alberto Jiménez Morales, María Teresa Sanz Martínez, Mónica Martínez Gallo, Roger Colobran, Helena Genestal Vicente, Nerea Moreno Pena, Roxana Paola Bury Macías, José Bruno Montoro Ronsano   +10 more
wiley   +1 more source

Pharmacogenetics and laboratory medicine: from individual genes towards integral genetic testing. [PDF]

Adv Lab Med
Serra MB, Isidoro-García M.
europepmc   +1 more source

Subgroup Identification via Multiple Change Point Detection: Methods and Applications

WIREs Computational Statistics, Volume 18, Issue 2, June 2026.
Subgroup identification methods facilitate the discovery of clinically meaningful subpopulations with differing disease progression, improving personalized risk assessment and treatment strategies. ABSTRACT Subgroup identification is a significant research area in statistics and machine learning, aiming to partition a heterogeneous population into more
Yaguang Li, Jingli Wang, Da Zhao, Jialiang Li   +3 more
wiley   +1 more source

Pharmacogenetic biomarkers for predicting therapeutic response to JAK inhibitors in rheumatoid arthritis. [PDF]

Adv Lab Med
Plasencia-Rodríguez C, Novella-Navarro M, Valdivieso Shephard JL, Martínez-Feito A, Reche-Yebra K, Juárez-García M, Villalba-Yllán A, Rubio-Lepe TS, Arias P, Collada Sánchez VL, Martin-López S, Losantos-García I, Borobia AM, Rosas-Alonso R.   +13 more
europepmc   +1 more source

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 7, Page 1394-1404, June 2026.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill, Marleen M. H. J. van Gelder, Hilde M. Engjom, Hedvig M. E. Nordeng   +3 more
wiley   +1 more source

Molecular Oncodiagnostics in Precision Oncology: Integrating Tumor Transcriptomics, Patient Pharmacogenetics, and Ex Vivo Chemoresistance Testing to Improve Individual Chemotherapy Response. [PDF]

J Pers Med
Rusciano D.
europepmc   +1 more source

Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Sodium glucose cotransporter‐2 (SGLT2) inhibitors are a class of antidiabetics with benefits including HbA1c‐lowering, weight loss, cardiovascular and renal protection in addition to adverse effects including genitourinary tract infections, ketoacidosis, and bone loss.
May E. Montasser, Salma A. Bargal, Elizabeth A. Streeten, Hilary B. Whitlatch, Zhinous Shahidzadeh Yazdi, Jordin Sirody, Rosanna Kiplagat, Merna Beshara, Jeffrey R. O’Connell, Simeon I. Taylor, Amber L. Beitelshees   +10 more
wiley   +1 more source

An Update to the Clinical Pharmacogenetics Implementation Consortium (CPIC) SLCO1B1 Allele Functionality Table Leveraging Evidence from Participants of Predominantly Sub-Saharan African Ancestry. [PDF]

Clin Pharmacol Ther
Oni-Orisan A, Yee SW, Haldar T, Whirl-Carrillo M, Caudle K, Voora D, Kim RB.   +6 more
europepmc   +1 more source

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source