Results 191 to 200 of about 34,807 (281)

The Psychosocial Impact of Receiving Whole Genome and Whole Exome Sequencing Results in Adults: A Systematic Review

Journal of Genetic Counseling, Volume 35, Issue 5, October 2026.
ABSTRACT The expanding use of whole genome sequencing (WGS) and whole exome sequencing (WES) underscores the need to better understand the psychosocial impact of receiving a broader range of potential results than those generated by other types of genetic testing.
Monica Albu, Andrada Ciucă, Ramona Moldovan   +2 more
wiley   +1 more source

UGT1A1 and irinotecan: Ready for routine pharmacogenetic care. [PDF]

Br J Clin Pharmacol
Swen JJ.
europepmc   +1 more source

Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2517-2525, October 2026.
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe, Sergio García‐Díaz, Laura Muñoz‐Delgado, Miguel Martín‐Bórnez, Silvia Jesús, Dolores Buiza‐Rueda, Marta Bonilla‐Toribio, Rafael Díaz‐Belloso, Daniel Macías‐García, Astrid Adarmes‐Gómez, Antonio Luque‐Ambrosiani, Rocío Pineda‐Sánchez, Lorena Clavijo‐Jiménez, Fátima Carrillo‐García, Pilar Gómez‐Garre, Pablo Mir   +15 more
wiley   +1 more source

Limited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature. [PDF]

Clin Transl Sci
Dello Russo C, Venetucci L, Akintola A, Gagliardi D, Ramlogan R, Pirmohamed M.   +5 more
europepmc   +1 more source

Association Between CYP2C19 Genotype and P2Y12 Reaction Units in Patients Receiving Clopidogrel After Acute Ischemic Stroke: A Prospective, Observational Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Recurrent stroke accounts for substantial morbidity and mortality worldwide, with up to 25% of ischemic strokes occurring in patients with prior strokes. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard for secondary prevention after minor acute ischemic stroke (AIS) or high‐risk transient ischemic attack ...
Rachael M. Stone, Annie Smith, Sonya Gunter, Andrew T. Weko, Carter Gottschalk, Cheyenne Lee, Allison Ramsey, Miah Perch Weatherspoon, Bradford B. Worrall   +8 more
wiley   +1 more source

Concurrent Antidepressant Use and Metastasis Risk Among Women Receiving Tamoxifen for Breast Cancer: A Real‐World Cohort Study

Psycho-Oncology, Volume 35, Issue 10, October 2026.
ABSTRACT Objective Concurrent use of antidepressants, particularly cytochrome P450 2D6 (CYP2D6) inhibitors, may reduce tamoxifen bioactivation and effectiveness. However, the clinical significance of this potential interaction remains inconclusive. This study examined whether concurrent antidepressant use is associated with increased metastasis risk ...
Shaimaa Elshafie, Mohammed Zuber, Ainhoa Gomez‐Lumbreras, Daniel C. Malone, Lorenzo Villa Zapata   +4 more
wiley   +1 more source

Pharmacogenetic analyses in people with dementia in Northeast Germany. [PDF]

Alzheimers Dement (Amst)
Meyer-Tönnies MJ, Schwarz L, Wucherer D, Hoffmann W, Thyrian JR, Tzvetkov MV.   +5 more
europepmc   +1 more source

Population Pharmacokinetics of Dolutegravir in Plasma and Cerebrospinal Fluid in Adults Living With HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Characterizing dolutegravir penetration into the central nervous system is important for optimizing human immunodeficiency virus treatment outcomes, yet population‐specific pharmacokinetic data describing cerebrospinal fluid disposition and equilibration kinetics remain lacking.
Mohammed W. Ali, Sam Nightingale, Tracy Kellermann, John Joska, Alan Winston, Saye Khoo, Joseph F. Standing, Eric H. Decloedt, Ahmed A. Abulfathi   +8 more
wiley   +1 more source

Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease: Is the Field Ready for Precision Prescribing? [PDF]

J Pers Med
Jaja C, Sop DM, Campbell A, Smith WR.
europepmc   +1 more source

Reframing the Landscape for Achieving Equitable Pharmacotherapy Health Outcomes: Introducing Pharmacogenequity

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 840-843, October 2026.
Akinyemi Oni‐Orisan
wiley   +1 more source