Results 181 to 190 of about 34,807 (281)

A PRISMA-guided systematic review of pharmacogenetic anticancer clinical trials registered on clinicaltrials.gov. [PDF]

Medicine (Baltimore)
Ashour AM, Alhayyan A, Alhayyan R.
europepmc   +1 more source

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 966-978, October 2026.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System. [PDF]

Pharmaceuticals (Basel)
Arias-Aragón F, Mata-Martín C, Sánchez-Redondo A, Novalbos J, Seguido MÁ, Abad-Santos F, Hernaez M, Brunet M, Heredero-Jung DH, Sota-Pérez A, Isidoro-García M, Gil-Rodriguez A, Barral-Raña A, Maroñas O, Pasquini GGO, Zucchet EG, Herrero MJ, Dodero-Anillo JM, Máñez AA, Pedrosa-Martínez MJ, Llerena A, On Behalf Of The BioFRAM PGx Consortium.   +21 more
europepmc   +1 more source

Erratum to 'Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk' [Journal of Lipid Research 59/10 (2018) 1987-2000]. [PDF]

J Lipid Res
Zhou Y, Mägi R, Milani L, Lauschke VM.
europepmc   +1 more source

CYP2C19 Genotyping to Guide Clopidogrel Prescribing for Neurovascular Indications: A Survey of Institutional Approaches

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 937-942, October 2026.
Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is commonly used for secondary prevention following acute ischemic stroke (AIS) and neurointerventional procedures. However, the efficacy of clopidogrel is reduced in carriers of CYP2C19 no‐function alleles.
Rachael M. Stone, Glenda Hoffecker, April Schultz, Brittney H. Davis, Salma A. Bargal, Amber L. Beitelshees, Nihal El Rouby, Madeline Norris, Kevin J. Rodriguez, Nita Limdi, Larisa H. Cavallari, Craig R. Lee   +11 more
wiley   +1 more source

Implementing pharmacogenetic-guided prescribing in general practice: a qualitative process evaluation. [PDF]

Implement Sci Commun
Brunton L, Newman W, McDermott J, Wilson P.   +3 more
europepmc   +1 more source

Clinical Function Assignment of NAT2 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1101-1110, October 2026.
NAT2 encodes arylamine N‐acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 ...
Bailey M. Tibben, David W. Hein, Michelle Whirl‐Carrillo, Andrea Gaedigk, Michael T. Eadon, Rodney F. Minchin, Sotiria Boukouvala, Adalberto Rezende Santos, Roseann S. Donnelly, José A. G. Agúndez, Kelly E. Caudle   +10 more
wiley   +1 more source

Correction: Precision management of cenobamate in drug-resistant epilepsy: integrating pharmacogenetics, therapeutic drug monitoring, and real-world clinical strategies. [PDF]

Front Pharmacol
d'Orsi G, Di Claudio MT, Cafaro A, Barco S, Robustella M, Locatelli N, Liantonio A, Imbrici P, Ciavarella G, Rinaldi A, Fania G, Costantino U, Carella M, Cangemi G, Miscio G.   +14 more
europepmc   +1 more source

Integrating CRISPR functional genomics with admixture-aware psychotropic pharmacogenetics in Brazil. [PDF]

Front Pharmacol
Rodrigues BB, Bittencourt JC, Dos Santos VGM, Costamilan CADVL, Herkenhoff ME.   +4 more
europepmc   +1 more source

Hong Kong Poison Information Centre: Annual report 2022

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 5, October 2026.
Abstract Background The Hong Kong Poison Information Centre (HKPIC) has been providing consultation services to healthcare professionals and collecting epidemiological data on poisoning in Hong Kong since 2005. Objective To analyse and report the poisoning data from HKPIC in 2022.
Tin Yat Anthony Chow, Chi Keung Chan, Shan Liu, Sze Hong Ng, Man Li Tse   +4 more
wiley   +1 more source