Results 151 to 160 of about 57,996 (259)

Testing DAT1 and DRD4 Genes in Attention Deficit Hyperactivity Disorder Using a Wide Spectrum of Neurocognitive Batteries

International Journal of Developmental Neuroscience, Volume 86, Issue 3, May 2026.
This study examined DAT1 and DRD4 VNTR polymorphisms and neurocognitive performance in 336 children and adolescents with ADHD and controls using the CNS Vital Signs battery. DAT1 10R/10R showed no significant effects after adjustment, whereas DRD4 4R/4R was associated with reduced cognitive flexibility. ABSTRACT Attention‐deficit/hyperactivity disorder
Gül Ünsel‐Bolat, Hilmi Bolat, Sema Yıldırım, Semiha Özgül, Akın Tahıllıoğlu, Kemal Utku Yazıcı, Ali Bacanlı, Erhan Parıltay, Duygu Aygüneş‐Jafari, Buket Kosova, Luis Augusto Rohde, Haluk Akın, Eyüp S. Ercan   +12 more
wiley   +1 more source

Pharmacogenetics of follicle‐stimulating hormone action in the male

Andrology, Volume 14, Issue 4, Page 1064-1072, May 2026.
Abstract Male factor infertility (MFI) is involved in half of the cases of couple infertility. The follicle‐stimulating hormone (FSH) therapy is considered efficient to improve semen parameters and pregnancy rate in patients with idiopathic MFI, following the lesson learned from hypogonadotropic hypogonadism.
Andrea Graziani, Giuseppe Grande, Raffele Scafa, Riccardo Selice, Andrea Garolla, Maria Santa Rocca, Cinzia Vinanzi, Alberto Ferlin   +7 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

British Journal of Pharmacology, Volume 183, Issue 10, Page 2482-2496, May 2026.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng, Darcy R. Flora, Mutaz M. Jaber, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy   +5 more
wiley   +1 more source

How Has the Rise of Direct‐To‐Consumer Genetic Testing Impacted Genetic Counselling Practice? A Scoping Review

Clinical Genetics, Volume 109, Issue 5, Page 819-836, May 2026.
This scoping review consolidated research on genetic health practitioners' (GHPs) and direct to consumer genetic testing (DTC‐GT) consumer needs and identified gaps. Thematic analysis identified four domains: GHPs' views, GHPs' perceptions of the impact of DTC‐GT on consumers, how DTC‐GT impacted services and how DTC‐GT impacted roles.
Cushla McKinney, Giselle Newton, Vaishnavi Nathan, Aideen McInerney‐Leo   +3 more
wiley   +1 more source

Genotyping of DPYD and UGT1A1 in Brazilian oncological patients: applying pharmacogenomics in an admixed population. [PDF]

Rev Assoc Med Bras (1992)
Cereser VHB, Moniz CMV, Suarez-Kurtz G, Estevez-Diz MDP.   +3 more
europepmc   +1 more source

A Pilot Study to Explore Length and Readability Characteristics of Subject Information Sheets/Informed Consent Forms of Clinical Trial Applications in the EU

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT The Clinical Trials Information System (CTIS) enables a central joint registration of clinical trials in the EU and provides public access to key trial documents including informed consent documents. The increasing complexity and length of subject information sheets and informed consent forms (SIS/ICFs) can impact participant comprehension and
Sophie Brunner Ziegler, Fabian Eibensteiner, Nina Reumann, Martin Brunner, Franz König, Eva Maria Zebedin Brandl   +5 more
wiley   +1 more source

Psychotropic pharmacogenetics [PDF]

Australian & New Zealand Journal of Psychiatry, 2016
openaire   +2 more sources

Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation‐Wide Study by the Italian Melanoma Intergroup (IMI)

Pigment Cell &Melanoma Research, Volume 39, Issue 3, May 2026.
In a large multicentre Italian cohort (14,081 melanoma cases from 19 centres), rare BRAF mutations (~2%) showed survival and response to targeted therapy comparable to V600E/K. Functional modeling indicates that variants, particularly near codon 600, can induce constitutive activation, supporting expanded BRAF genotyping to identify additional patients
Bruna Dalmasso, Maria Chiara Scaini, Laura Cendron, Monica Rodolfo, Ilaria Mattavelli, Elena Tamborini, Francesca Collina, Gerardo Ferrara, Gabriele Madonna, Carlo Cota, Elisa Melucci, Stefania Tommasi, Martina Ubaldi, Roberta Depenni, Andrea Carugno, Riccardo Marconcini, Laura Orgiano, Maurizio Lombardo, Simona Sola, Cristina Pellegrini, Francesca Castiglione, Matteo Gasparotto, Alireza Jorkesh, Stefania Pellegrini, Edoardo Raposio, Andrea Boutros, Enrica Teresa Tanda, Michele Guida, Pietro Quaglino, Giuseppe Palmieri, Daniela Massi, Paolo Antonio Ascierto, Francesco Spagnolo, Mario Mandalà, Chiara Menin, Paola Ghiorzo, Lorenza Pastorino, Italian Melanoma Intergroup, Lorenza Di Guardo, Roberto Patuzzo, Maria Colombino, Simone Ribero, Rebecca Senetta, Gabriele Roccuzzo, Maria Concetta Fargnoli, Cesare Massone, Maria Lentini, Giuseppe Giuffrè, Teresa Troiani, Denise Morotti, Miriam Paone   +50 more
wiley   +1 more source

Pharmacogenetics and laboratory medicine: from individual genes towards integral genetic testing. [PDF]

Adv Lab Med
Serra MB, Isidoro-García M.
europepmc   +1 more source