Results 151 to 160 of about 34,807 (281)

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2378-2389, November 2026.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients

Molecular Medicine
Background Patient-derived xenograft (PDX) is currently considered a preferred preclinical model to evaluate drug sensitivity, explore drug resistance mechanisms, and select individualized treatment regimens.
Xiaoqing Wang, Ju Zhu, Lingling Li, Qilin Zhao, Yutang Huang, Chunjie Wen, Dan Chen, Lanxiang Wu   +7 more
doaj   +1 more source

g-Nomic: a new pharmacogenetics interpretation software

, 2019
Ana Sabater,1 Carlos J Ciudad,2 Marc Cendros,1 Denis Dobrokhotov,1 Juan Sabater-Tobella11Department of Information Technology, EUGENOMIC, Barcelona 08012, Spain; 2Department of Biochemistry and Physiology, University of Barcelona, Barcelona 08028 ...
Dobrokhotov D, Cendros M, Sabater A, Ciudad CJ, Sabater-Tobella J   +4 more
core  

Development and Validation of Two Analytical Methods Using High‐Performance Liquid Chromatography and Atomic Absorption Spectroscopy for the Analysis of Tunisian Marketed Pharmaceutical Product‐Based Insulin and Zinc: Application in Routine Stability Study

Biomedical Chromatography, Volume 40, Issue 11, November 2026.
ABSTRACT Given the widespread reliance on insulin among diabetic patients, ensuring its stability is an essential task not only for preserving its therapeutic efficacy but also for safeguarding patient health and safety. In addition, insulin storage practices were frequently misunderstood that may compromise drug potency.
Majdi Ben Messaoud, Sarra Mahfoudhi, Dorra Amor, Yassine Mokni, Kaouther Louati, Kaouther Zribi, Asma Omezzine, Fathi Safta   +7 more
wiley   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

From Fragmentation to Standardization: A Systematic Review Update and Critical Appraisal of Genetic and Genomic Testing Assessment Frameworks and Their Alignment With the HTA Core Model

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims Owing to their distinct features, genetic/genomic technologies have traditionally been assessed using tailored approaches, with no standardized methodology emerging to date. The Health Technology Assessment (HTA) Core Model (version 3.0), adopted within the European Union HTA Regulation, is a rigorous framework for health ...
Valentina Baccolini, Antonio Sciurti, Erica Pitini, Leonardo Maria Siena, Arianna Anniballo, Anna Ewa Kaminska, Andrea Pistollato, Romina Pausilli, Chiara Tommasino, Carolina Marzuillo, Corrado De Vito, Giuseppe La Torre, Giuseppe Migliara, Paolo Villari   +13 more
wiley   +1 more source

Pharmacogenetics: ethical issues and policy options

, 2002
Pharmacogenetics offers the prospect of an era of safer and more effective drugs, as well as more individualized use of drug therapies. Before the benefits of pharmacogenetics can be realized, the ethical issues that arise in research and clinical ...
Brody, Baruch, Robertson, John, McPherson, Elizabeth, Buchanan, Allen, Kahn, Jeffrey, Califano, Andrea   +5 more
core  

Clinical Decision‐Making During Monitoring Episodes in Advanced Therapy Management for Inflammatory Bowel Disease: A National Nurse‐Led Service Evaluation

JCC Plus, Volume 1, Issue 6, November 2026.
This national, multisite, nurse‐led evaluation highlights practice patterns across UK IBD centres, revealing reliance on reactive flare‐driven treatment modification. Balancing this with structured proactive surveillance and therapeutic drug monitoring aligns with treat‐to‐target principles and supports safer advanced therapy care across diverse ...
Vida Cairnes, Dominic Devine, Susie Wen, Hayley Owen, Isobel Mason, Beverley Kirkham, Wendi Harrison, Raymoncler Diaz, Kerry Robinson, Monica Chan, Rachel Campbell, Tracey Tyrell, Lynn Gray, Michelle Clarke, Sarah Hawkins, Gaz Lloyd‐Ford, Heather Johnson, Gayle Martin, Pearl Avery   +18 more
wiley   +1 more source

Machine Learning–Augmented Precision Dosing: Integrating Pharmacokinetic Modeling With Clinical Decision Support

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT Inter‐individual variability in drug exposure can lead to ineffective therapy or toxicity, particularly in vulnerable patients. Routine model‐informed precision dosing (MIPD) relies mainly on population pharmacokinetic (PopPK) models, Bayesian forecasting, and therapeutic drug monitoring (TDM).
Yunmeng Pang, Bingqi Zhang, Zhiqiu He, Yuliu Li, Jiaxin Yu, Wei Zuo   +5 more
wiley   +1 more source