Results 121 to 130 of about 30,618 (276)

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia

BMC Psychiatry
Background Clinical and genetic studies have suggested that immune dysregulation and neuroinflammation are involved in the pathogenesis of schizophrenia.
Héctor Cabello-Rangel, Carlo Esteban Sotelo-Ramírez, Joanna Jiménez-Pavon, Marco Antonio Sanabrais-Jiménez, Pamela Morales-Cedillo, Beatriz Camarena   +5 more
doaj   +1 more source

Context, ethics and pharmacogenetics

, 2006
Most of the literature on pharmacogenetics assumes that the main problems in implementing the technology will be institutional ones (due to funding or regulation) and that although it involves genetic testing, the ethical issues involved in ...
Adam M. Hedgecoe, A. M. Hedgecoe (16042331)   +1 more
core   +1 more source

Insights from a six‐year hair drug analysis compendium in drug‐facilitated crimes involving vulnerable population cases

Journal of Forensic Sciences, EarlyView.
Abstract Hair analysis is a well‐established matrix in forensic toxicology, offering a valuable alternative or complement to traditional matrices in diverse contexts, including drug‐facilitated crimes (DFC), elder abuse, and accidental exposure in children.
Amandine Fort, Coralie Boudin, Hélène Eysseric‐Guerin, Virginie Scolan, François Paysant, Cloé Scherpereel, Mélissa Revet, Françoise Stanke‐Labesque, Théo Willeman   +8 more
wiley   +1 more source

Insights from a 6‐year hair drug analysis compendium in drug‐facilitated sexual assault cases

Journal of Forensic Sciences, EarlyView.
Abstract Drug‐facilitated sexual assault (DFSA) may involve a diverse array of substances, including illicit drugs, prescription medications, and over‐the‐counter pharmaceuticals. Hair analysis has emerged as a valuable forensic tool, offering an extended window of detection spanning several months. However, interpreting drug concentrations in hair can
Amandine Fort, Coralie Boudin, Hélène Eysseric‐Guerin, Virginie Scolan, Jérémy Borges, François Chiron, Pierre Henry, Françoise Stanke‐Labesque, Théo Willeman   +8 more
wiley   +1 more source

Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy

Nature Communications
The multifaceted chemo-immune resistance is the principal barrier to achieving cure in cancer patients. Identifying a target that is critically involved in chemo-immune-resistance represents an attractive strategy to improve cancer treatment.
Zhangyi Luo, Yixian Huang, Neelu Batra, Yuang Chen, Haozhe Huang, Yifei Wang, Ziqian Zhang, Shichen Li, Chien-Yu Chen, Zehua Wang, Jingjing Sun, Qiming Jane Wang, Da Yang, Binfeng Lu, James F. Conway, Lu-Yuan Li, Ai-Ming Yu, Song Li   +17 more
doaj   +1 more source

Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity

Acta Pharmaceutica Sinica B
One of the leading therapies for acute lymphoblastic leukemia (ALL) is the chemotherapeutic agent PEGylated E. coli-derived-l-asparaginase (PEG-ASNase).
Yin Zhu, Yuyin Wang, Keito Hoshitsuki, Da Yang, Lauren Kokai, Xiaochao Ma, Wen Xie, Christian A. Fernandez   +7 more
doaj   +1 more source

A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response

, 2003
We aimed to develop a microarray genotyping system for multiplex analysis of a panel of single nucleotide polymorphisms (SNPs) in genes encoding proteins involved in blood pressure regulation, and to apply this system in a pilot study demonstrating its ...
Karlsson, J, Melhus, Håkan,, Lind, Lars,, Kahan, T,, Liljedahl, U, Lind, L, Melhus, H, Lindersson, Marie,, Kahan, Thomas,, Kurland, Lisa,, Lindersson, M, Nyström, F, Karlsson, Julia,, Kurland, L, Nyström, Fredrik,, Syvänen, Ann-Christine,, Liljedahl, Ulrika,, Kahan, T, Kurland, L,, Syvanen, AC   +19 more
core   +1 more source

Impact of FSHB and FSHR Genes Polymorphisms on Hormonal Profile and Sperm Retrieval Outcome in Men With Klinefelter Syndrome: A Clinical–Genetic Predictive Study

Andrology, EarlyView.
ABSTRACT Background Genetic variability within the follicle‐stimulating hormone (FSH)‐related genes might contribute to phenotypic heterogeneity in patients with Klinefelter syndrome (KS), yet its clinical impact on sperm retrieval remains unclear. Objectives To investigate the association between FSHB c.211 G > T and FSHR polymorphisms (c.2039 A > G ...
Andrea Graziani, Giuseppe Grande, Maria Santa Rocca, Massimo Iafrate, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +6 more
wiley   +1 more source

The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model

Hepatology Communications
Background:. The prevalence of NAFLD is rapidly increasing. NAFLD can progress to NASH, fibrosis, cirrhosis, and HCC, which will soon become the main causes of liver transplantation.
Sander van Riet, Anais Julien, Andrea Atanasov, Åsa Nordling, Magnus Ingelman-Sundberg   +4 more
doaj   +1 more source