Results 121 to 130 of about 34,807 (281)

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel. [PDF]

Clin Pharmacol Ther
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Tibben BM, Maillard M, Pratt VM, Moyer AM, Figueroa DM, Whirl-Carrillo M, Gaedigk A, Stocco G, Schwab M, Caudle KE, Yang JJ.   +10 more
europepmc   +2 more sources

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Biological and prognostic relevance of A-to-I RNA editing across consensus molecular subtypes of colon cancer

Scientific Reports
Colorectal cancer (CRC) is the second most frequently diagnosed cancer worldwide and represents a major challenge for public health. Despite advances in molecular profiling, important gaps remain in our understanding of tumorigenesis and the regulatory ...
Dario Monaco, Debora Traversa, Eliseo Mattioli, Francesco Alfredo Zito, Grazia Cristiani, Francesca Buono, Sabina Delcuratolo, Tiziana Guarino, Rosamaria Pinto, Antonia Lasorella, Rosanna Lacalamita, Ernesto Picardi, Stefania Tommasi, Simona De Summa   +13 more
doaj   +1 more source

Insights from Bibliometric Analysis of Epilepsy Research in Morocco between 1969 and 2024

Psychiatry International
Epilepsy is a critical neurological condition characterized by the disturbance of the excitatory neuron network, resulting in recurrent seizures. It is a serious health problem requiring intensive attention.
Abdelaziz Zennati, Driss Ousaaid, Youssef Khabbal   +2 more
doaj   +1 more source

Impact of FSHB and FSHR Genes Polymorphisms on Hormonal Profile and Sperm Retrieval Outcome in Men With Klinefelter Syndrome: A Clinical–Genetic Predictive Study

Andrology, EarlyView.
ABSTRACT Background Genetic variability within the follicle‐stimulating hormone (FSH)‐related genes might contribute to phenotypic heterogeneity in patients with Klinefelter syndrome (KS), yet its clinical impact on sperm retrieval remains unclear. Objectives To investigate the association between FSHB c.211 G > T and FSHR polymorphisms (c.2039 A > G ...
Andrea Graziani, Giuseppe Grande, Maria Santa Rocca, Massimo Iafrate, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +6 more
wiley   +1 more source

The diffusion of innovation: factors influencing the uptake of pharmacogenetics

, 2007
 BACKGROUND: Inspired by diffusion research, this paper examines how perceived need, health status, experiences with medicine and testing, consumption of mass media and sociodemography influence the public's familiarity, knowledge, attitudes and ...
Nielsen, Louise Fuks, Møldrup, Claus
core   +1 more source

Pharmacogenetics and individualizing drug treatment during pregnancy

, 2014
Pharmacogenetics as a tool to aid clinicians implement individualized pharmacotherapy is utilized in some areas of medicine. Pharmacogenetics in pregnancy is still a developing field.
Haas, David M.
core   +1 more source

Maternal Obesity Is Associated With Adverse Pregnancy Outcomes in Inflammatory Bowel Disease: A Matched Electronic Health Record Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
More than one in five pregnancies in women with IBD were complicated by obesity. Obesity was strongly associated with adverse pregnancy outcomes, whereas this study did not identify a significant additional effect attributable to IBD diagnosis alone.
Christopher Roberts, Rebecca Smith, Safwat Odeh, Nathan Kuk, Ayushi Chauhan, Claire Bewshea, Vida Cairnes, Hayley Toll, Nick Kennedy, James Goodhand, Tariq Ahmad, Jennifer Blackman, Alex Bain, Sally Bell, Jennie Clough   +14 more
wiley   +1 more source

Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications

Pharmacogenomics and Personalized Medicine, 2019
Frederick Zhang,1 Joseph Finkelstein21Center for Bioinformatics and Data Analytics, Columbia University Irving Medical Center, New York, NY, USA; 2Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY ...
Zhang F, Finkelstein J
doaj