Results 101 to 110 of about 34,807 (281)

Pharmacogenetics in clinical dermatology

, 2002
Systemic therapies are increasingly used in the management of common skin diseases, and drug toxicity and relative lack of efficacy remain significant problems.
Ameen, M, Smith, C H; id_orcid, Barker, J N W N   +2 more
core   +2 more sources

A Pilot Randomized Study of NAT2 and YEATS4 Pharmacogenetic Return of Results in Adults with Hypertension and African Ancestry: The GUARDD‐US PGx Study

Clinical Pharmacology &Therapeutics, EarlyView.
Almost half of individuals with hypertension fail to achieve recommended blood pressure (BP) goals. Pharmacogenetic gene‐drug interactions may alter the efficacy of antihypertensive agents. We conducted a multicenter randomized controlled sub‐study of participants (N = 1874) with hypertension and self‐reported African ancestry to determine whether ...
Philip E. Empey, Nita A. Limdi, Dinushika Mohottige, Kady‐Ann Steen‐Burrell, Hrishikesh Chakraborty, Khoa A. Nguyen, Alexander S. Parker, Emily J. Cicali, Girish N. Nadkarni, Michelle A. Ramos, Sabrina Clermont, Erica N. Elwood, Mimsie Robinson, Nandini Shroff, Marc B. Rosenman, Ronald Huang, Larisa H. Cavallari, Julie A. Johnson, Paul R. Dexter, Todd C. Skaar, Kerri L. Cavanaugh, Christina M. Wyatt, Carol R. Horowitz, Rhonda M. Cooper‐DeHoff, Michael T. Eadon, on behalf of the IGNITE Pragmatic Trials Network   +25 more
wiley   +1 more source

A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation

Nature Communications
Inflammatory bowel disease (IBD) arises from genetic-environmental interactions. Adenosine deaminases acting on RNA 1 (ADAR), an RNA-editing enzyme converting adenosine (A) to inosine (I), is essential for tissue homeostasis.
Pengfei Xu, Yue Xi, Jong-Won Kim, Min Zhang, Chen Gao, Yue Wang, Meishu Xu, Xingchen Wang, Songrong Ren, Da Yang, Qingde Wang, Wen Xie   +11 more
doaj   +1 more source

Removing barriers to a clinical pharmacogenetics service

, 2008
Pharmacogenetics has been proposed as a new discipline to facilitate safer and more effective prescribing by predicting individuals who will have a therapeutic response or develop side effects.
Newman, William; id_orcid, Payne, Katherine; id_orcid   +1 more
core   +1 more source

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

Transgenic overexpression of steroid sulfatase alleviates cholestasis

Liver Research, 2017
Background and Aim: Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and functional homeostasis of endogenous and exogenous molecules.
Mengxi Jiang, Meishu Xu, Songrong Ren, Kyle W. Selcer, Wen Xie   +4 more
doaj   +1 more source

Awareness regarding clinical application of pharmacogenetics among Japanese pharmacists

, 2015
Taku Obara,1–3 Shinya Abe,4 Michihiro Satoh,1 Sergio Ramón Gutiérrez Ubeda,5 Shoko Yoshimachi,4 Teruaki Goto4 1Department of Pharmacy, Tohoku University Hospital, Sendai, 2Division of Molecular Epidemiology, Environment and Genome ...
Obara T, Abe S, Yoshimachi S, Gutiérrez Ubeda SR, Satoh M, Goto T   +5 more
core  

CDK4/6 inhibitors in metastatic breast cancer: Pharmacogenetics of ADME genes to predict differences in toxicity and treatment schedule adherence

, 2022
reservedCDK4/6 inhibitors, palbociclib, ribociclib, abemaciclib, are the gold standard for the treatment of luminal-like metastatic breast cancer.
NUZZO, SOFIA
core  

Change in clobazam pharmacokinetics after introduction of cenobamate

Epilepsia, EarlyView.
Abstract Cenobamate is a new antiseizure medication with an unusually high seizure‐free rate, resulting in frequent use in patients with drug‐resistant epilepsy. Many of these patients are taking clobazam (CLB) at baseline. Cenobamate has important interactions with CLB, requiring CLB dose adjustment in conjunction with cenobamate titration.
Melissa R. Osborn, Kevin F. Haas, Bassel W. Abou‐Khalil   +2 more
wiley   +1 more source

Redox regulation by sulfiredoxin-1: bridging cysteine oxidation and liver disease therapeutics

Experimental and Molecular Medicine
Cysteine (Cys) posttranslational modifications play a critical role in regulating protein function, cellular signaling and redox homeostasis in various physiological and pathological conditions.
Jong-Won Kim, Mengyun Ke, Donovan Whitfield, Bin Yang, Gu Seob Roh, Wen Xie   +5 more
doaj   +1 more source