Results 101 to 110 of about 52,343 (282)

Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria

Nature Communications
Erythropoietic protoporphyria (EPP) is a genetic disease characterized by protoporphyrin IX-mediated painful phototoxicity. Currently, options for the management of EPP-associated phototoxicity are limited and no oral medication is available.
Junjie Zhu, Fu-Ying Qin, Saifei Lei, Ruizhi Gu, Qian Qi, Jie Lu, Karl E. Anderson, Peter Wipf, Xiaochao Ma   +8 more
doaj   +1 more source

Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Therapeutic drug monitoring for astronauts faces limitations in conventional blood sampling and sample management onboard the international space station. Here, we explore the feasibility of dried blood spot (DBS) collection during parabolic flights (PF) to overcome these constraints.
Audrey Derobertmasure, Li Shean Toh, Céline Verstuyft, Srboljub Lukic, Christelle De Sousa Carvalho, Raphaël Couronné, Marie Beauvalet, Stéphanie Chhun, Pierre Boutouyrie   +8 more
wiley   +1 more source

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

Pediatric nephrology (Berlin, West), 2018
Nephrotic syndrome is one of the most common glomerular disorders in childhood. Glucocorticoids have been the cornerstone of the treatment of childhood nephrotic syndrome for several decades, as the majority of children achieves complete remission after ...
A. Schijvens, R. ter Heine, S. D. de Wildt, M. Schreuder   +3 more
semanticscholar   +1 more source

The interplay between hepatocyte nuclear factor 4α (HNF4α) and cholesterol sulfotransferase (SULT2B1b) in hepatic energy homeostasis

Liver Research, 2019
The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4α) plays a critical role in the regulation of metabolic homeostasis, including glucose homeostasis.
Yuhan Bi, Youya Wang, Wen Xie
doaj   +1 more source

Pharmacogenetics and the Halothane Hepatitis Myster [PDF]

, 1981
Burnell R. Brown
openalex   +1 more source

Defining Treatment‐Resistant Bipolar Depression: Recommendations From the ISBD Task Force

Bipolar Disorders, EarlyView.
ABSTRACT Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking.
Eduard Vieta, Roger S. McIntyre, Trisha Suppes, Tamsyn E. Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H. Young, Lakshmi N. Yatham, Kyooseob Ha, Michael Berk, Holly A. Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J. Cubała, Diego Hidalgo‐Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez‐Jaramillo, Ana Gonzalez‐Pinto, Paolo Brambilla, Robert Post, Jair C. Soares, Michael Bauer, Ana C. Andreazza, Xavier Justes Fradera, Montserrat Cosials‐Lopez, Giovanna Fico   +29 more
wiley   +1 more source

Pharmacogenetics and Halothane Hepatitis [PDF]

, 1982
Michael J. Cousins, G. K. GOURLAY, Pauline de la Μ. Hall, K. M. Knights   +3 more
openalex   +1 more source

Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Chemotherapeutic treatment for colorectal cancer (colorectal cancer) allows for increased patient overall survival. However, current therapeutic regimens are often associated with the development of adverse drug reactions, which represent a morbidity, mortality and economic issue.
Ana Rita Simoes, Silvia Carlés González, María del Carmen Lopez‐Doldan, Goretti Duran, Ana Fernández‐Montes, Maria Perfecta Fernandez, Mercedes Salgado Fernandez, Jesus Garcia Mata, David Paez, Pau Riera, Elisabeth Guino, Luis Lopez‐Fernandez, Belen Garcia de Santiago, Elena López Aspiroz, Augusto Rojas, Antoni Castells, Sergi Castellvi‐Bel, Clara Ruiz Ponte, Veronika Vymetalkova, Angel Carracedo, Ceres Fernandez‐Rozadilla   +20 more
wiley   +1 more source

Polymorphism rs662 (Q192R) of paraoxonase-1 and susceptibility to atherosclerosis of the coronary arteries

Archives of Medical Science
Introduction The present study concerns a connection of the Q192RPON1 polymorphism with atherosclerosis requiring percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the Polish population.
Malgorzata Baranska, Mariola Rychlik-Sych, Michał Dudarewicz, Anna Wiktorowska-Owczarek, Jacek Owczarek   +4 more
doaj   +1 more source

374 PHARMACOGENETIC PREDISPOSITION TO PHENYTOIN HEPATO-TOXICITY ASSESSED IN VITRO [PDF]

, 1981
Stephen P. Spielberg, Gary Gordon, Phillip J. Goldstein, David A. Blake   +3 more
openalex   +1 more source