Results 31 to 40 of about 52,343 (282)
The basic principals of pharmacogenetics testing in cancer treatment [PDF]
Hospital Pharmacology, 2020 Introduction: Precision medicine is an approach that considers genetics, environment and lifestyle factors when prevent and treat different diseases. The important part of precision medicine is pharmacogenetics, a branch of clinical pharmacology that ...
Cikota-Aleksić Bojana M. +3 more
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Pharmacogenetics of asthma [PDF]
European Respiratory Journal, 2000 Pharmacogenetics offers the potential to optimize treatment for individual patients by using genetic information to improve efficacy or avoid side effects. While there are a number of examples in which the approach is already in routine clinical usage, exploitation of this approach in asthma is still under development.
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Pharmacogenetics in Clinical Practice
Prague Medical Report, 2012 Pharmacogenetics is a discipline that investigates how genetic variation relates to the drug efficacy and safety. The goal of pharmacogenetics is a personalized treatment, where according to genotype we would be able to prescribe the most effective drug ...
Hana Bakhouche, O. Slanař
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The Clinical Pharmacogenetics Implementation Consortium: 10 Years Later
Clinical pharmacology and therapy, 2019 In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www.cpicpgx.org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) and the National Institutes of Health (NIH), was created to provide ...
M. Relling +5 more
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The role of pharmacogenetics in keloid scar treatment: A literature review
Scars, Burns & Healing, 2020 Background: The pathophysiology of keloid scars is still not fully understood and a universally reliable effective treatment has not been identified. Pharmacogenetics explores how drug response to a particular therapy can relate to genetic variations ...
Tamara Searle +2 more
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Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes. [PDF]
Ann Hum GenetABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
McDermott JH +3 more
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European Journal of Human Genetics, 2019 Despite advances in the field of pharmacogenetics (PGx), clinical acceptance has remained limited. The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize ...
C. Lunenburg +14 more
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Integrating rare genetic variants into pharmacogenetic drug response predictions
Human Genomics, 2018 Background Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions.
Magnus Ingelman-Sundberg +3 more
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Pharmacogenetics of thiopurines
Cancer Drug Resistance, 2019 Polychemotherapeutic protocols for the treatment of pediatric acute lymphoblastic leukemia (ALL) always include thiopurines. Specific approaches vary in terms of drugs, dosages and combinations. Such therapeutic schemes, including risk-adapted intensity, have been extremely successful for children with ALL who have reached an outstanding 5-year ...
Raffaella Franca +6 more
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Systematic identification of non-coding pharmacogenomic landscape in cancer
Nature Communications, 2018 In this study the authors build lncRNA-drug response models for 265 anti-cancer agents across 27 cancer types. They report their cancer cell line based lncRNA EN-models are able to effectively predict therapeutic outcome for breast cancer, ovarian cancer,
Yue Wang +6 more
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