Results 31 to 40 of about 88,087 (318)

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

Knowledge and attitude regarding pharmacogenetics among formerly pregnant women in the Netherlands and their interest in pharmacogenetic research

BMC Pregnancy and Childbirth, 2017
Background Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the ...
Aizati N. A. Daud, Eefke L. Bergsma, Jorieke E. H. Bergman, Hermien E. K. De Walle, Wilhelmina S. Kerstjens-Frederikse, Bert J. Bijker, Eelko Hak, Bob Wilffert   +7 more
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Clinical pharmacology and therapy, 2019
Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines.
M. Relling, M. Schwab, Michelle Whirl‐Carrillo, G. Suarez-Kurtz, C. Pui, C. Stein, A. Moyer, W. Evans, T. Klein, Federico Antillon-Klussmann, K. Caudle, Motohiro Kato, A. Yeoh, K. Schmiegelow, Jun J. Yang   +14 more
semanticscholar   +1 more source

Pharmacogenetics of ophthalmic topical β-blockers [PDF]

, 2008
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
McCarty, Catherine A., Patchett, Richard, Sidjanin, Duska J., Smith, Edward M., Wilke, Russell A.   +4 more
core   +1 more source

PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics

Journal of Clinical Medicine, 2021
The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion.
P. Zubiaur, G. Mejía-Abril, M. Navares-Gómez, Gonzalo Villapalos-García, Paula Soria-Chacartegui, M. Saiz-Rodríguez, D. Ochoa, F. Abad‐Santos   +7 more
semanticscholar   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

The basic principals of pharmacogenetics testing in cancer treatment [PDF]

Hospital Pharmacology, 2020
Introduction: Precision medicine is an approach that considers genetics, environment and lifestyle factors when prevent and treat different diseases. The important part of precision medicine is pharmacogenetics, a branch of clinical pharmacology that ...
Cikota-Aleksić Bojana M., Rančić Nemanja K., Ratković Nenad G., Dragojević-Simić Viktorija M.   +3 more
doaj  

Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug

Frontiers in Pharmacology, 2021
Objective: The elucidation of CYP2D6 developmental pharmacogenetics in children has improved, however, these findings have been largely limited to studies of Caucasian children.
Qian Li, Yue-E Wu, Kai Wang, Hai-Yan Shi, Yue Zhou, Yi Zheng, Guo-Xiang Hao, Yi-Lei Yang, Le-Qun Su, Wen-Qi Wang, Xin-Mei Yang, Wei Zhao, Wei Zhao   +12 more
doaj   +1 more source

Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy. [PDF]

, 2011
Our study shows that in Indonesian cancer patients treated with highly cytostatic emetogenic, carriership of the CTG haplotype of the ABCB1 gene is related to an increased risk of delayed chemotherapy-induced nausea and ...
Baak-Pablo, Renee F, Gelderblom, Hans, Guchelaar, Henk-Jan, Hakimi, Mohammad, Mustofa, Mustofa, Nortier, Johann W R, Perwitasari, Dyah A, van der Straaten, Robert J H M, Wessels, Judith A M   +8 more
core   +2 more sources

Pharmacogenetics of asthma [PDF]

European Respiratory Journal, 2000
Pharmacogenetics offers the potential to optimize treatment for individual patients by using genetic information to improve efficacy or avoid side effects. While there are a number of examples in which the approach is already in routine clinical usage, exploitation of this approach in asthma is still under development.
openaire   +5 more sources