Results 51 to 60 of about 52,343 (282)
Animal Models and Experimental Medicine, EarlyView.This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin +9 more
wiley +1 more source
Genetics in Medicine, 2016 Introduction:Reporting and sharing pharmacogenetic test results across clinical laboratories and electronic health records is a crucial step toward the implementation of clinical pharmacogenetics, but allele function and phenotype terms are not ...
K. Caudle +11 more
semanticscholar +1 more source
Application of pharmacogenetics in oncology
Biomarker Research, 2020 The term “pharmacogenetics” is used to describe the study of variability in drug response due to heredity. It is associated with “gene – drug interactions”.
Nelly N. Miteva-Marcheva +3 more
semanticscholar +1 more source
Lamivudine and tenofovir pharmacokinetic variability in people with HIV in Papua New Guinea
British Journal of Clinical Pharmacology, EarlyView.Aims Demographics and kidney function contribute to variability in lamivudine and tenofovir drug concentrations. The aim was to assess, for the first time, the pharmacokinetic variability of lamivudine and tenofovir in Papua New Guinean (PNG) HIV/AIDS patients.
Natália Bordin Andriguetti +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.We systematically reappraised meta‐analyses of pharmacogenetic studies to evaluate the credibility of association between gene polymorphisms and resistance to anti‐epileptic drugs (AEDs). A systematic search was performed in PubMed, Web of Knowledge, Cochrane Library and OpenGrey up to April 2025.
Martina Giacon +2 more
wiley +1 more source
Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Tacrolimus in Kidney Transplantation
Current drug metabolism, 2018 Background: Tacrolimus (Tac, or FK506), a calcineurin inhibitor (CNI), is the first-line immu-nosuppressant which consists of the footstone as immunosuppressive regimens in kidney transplantation.
Meng Yu, Mou-Ze Liu, Wei Zhang, Y. Ming
semanticscholar +1 more source
Recurrent fexuprazan‐induced liver injury following unintentional re‐exposure
British Journal of Clinical Pharmacology, EarlyView.Fexuprazan, a potassium‐competitive acid blocker, is increasingly used for the treatment of gastroesophageal reflux disease in South Korea. While generally well tolerated, data regarding its hepatotoxic potential are scarce. We report a case of idiosyncratic drug‐induced liver injury in a 61‐year‐old woman following 2 months of fexuprazan therapy.
Sook Jin Seong +5 more
wiley +1 more source
An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy
Nature Communications, 2016 The use of immunostimulatory agents to enhance the efficacy of chemotherapy is a promising strategy in cancer therapy. Here, the authors report on a micellar nanoparticle that can effectively co-deliver chemo- and immunotherapeutics, resulting in an ...
Yichao Chen +12 more
doaj +1 more source
Atypical functions of xenobiotic receptors in lipid and glucose metabolism
Medical Review, 2022 Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
doaj +1 more source
Pharmacogenetics of OPRM1 [PDF]
Pharmacology Biochemistry and Behavior, 2014 Pharmacogenetic research has the potential to explain the variation in treatment efficacy within patient populations. Understanding the interaction between genetic variation and medications may provide a method for matching patients to the most effective therapeutic options and improving overall patient outcomes.
Wade H. Berrettini, Richard C. Crist
openaire +3 more sources