Results 81 to 90 of about 88,087 (318)

Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer

Nature Communications
Chemo-immunotherapy combinations have been regarded as one of the most practical ways to improve immunotherapy response in cancer patients. In this study, we integrate the transcriptomics data from anti-PD-1-treated tumors and compound-treated cancer ...
Yue Wang, Dhamotharan Pattarayan, Haozhe Huang, Yueshan Zhao, Sihan Li, Yifei Wang, Min Zhang, Song Li, Da Yang   +8 more
doaj   +1 more source

Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]

, 2012
The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
core   +2 more sources

Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic

Journal of Clinical Medicine, 2020
Pharmacogenetic testing (PGT) is increasingly being used as a tool to guide clinical decisions. This article describes the development of an outpatient, pharmacist-led, pharmacogenetics consult clinic within internal medicine, its workflow, and early ...
Meghan J. Arwood, Eric A. Dietrich, Benjamin Q. Duong, D. M. Smith, Kelsey J Cook, Amanda L Elchynski, Eric I. Rosenberg, Katherine N. Huber, Ying Nagoshi, Ashleigh Wright, Jeffrey T. Budd, Neal P. Holland, Edlira Maska, Danielle K. Panna, Amanda R. Elsey, L. H. Cavallari, Kristin Wiisanen, Julie A. Johnson, J. Gums   +18 more
semanticscholar   +1 more source

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, EarlyView.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Cypc19*17 Polymorphism as a Risk-factor for Nsaids-induced Ulcers [PDF]

, 2016
The new risk-factors for peptic ulcers induced by the use of nonsteroidal antiinflammatory drugs, such as polymorphism of different isoenzymes of cytochrome P450 were considered in the article.
Balabanseva, A. (Alexandra), Onischuk, L. (Lyudmyla), Tkach, S. (Serhiy)   +2 more
core   +2 more sources

Pharmacogenetics in Practice: Estimating the Clinical Actionability of Pharmacogenetic Testing in Perioperative and Ambulatory Settings

Clinical and Translational Science, 2020
Most literature describing pharmacogenetic implementations are within academic medical centers and use single‐gene tests. Our objective was to describe the results and lessons learned from a multisite pharmacogenetic pilot that utilized panel‐based ...
D. M. Smith, B. Peshkin, T. Springfield, Ryan P. Brown, E. Hwang, Susanna Kmiecik, R. Shapiro, Z. Eldadah, Conor Lundergan, Joel McAlduff, Bonnie Levin, S. M. Swain   +11 more
semanticscholar   +1 more source

Cytochrome P450 2D6 *17 and *29 Allele Activity for Risperidone Metabolism: Advancing Precision Medicine Health Equity

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 alleles with low frequency in Eurocentrically biased study populations are often excluded from pharmacogenetic investigation and consequently may have misassigned activity values. This health inequity may be contributing to imprecise dose predictions for CYP2D6‐metabolizing drugs.
Oyinlade Kehinde, Samuel E. Vaughn, Ogochukwu Amaeze, Paul Toren, Brandon Retke, Akinyemi Oni‐Orisan, Laura B. Ramsey   +6 more
wiley   +1 more source

The perceptions of pharmacists in Victoria, Australia on pharmacogenetics and its implications

Pharmacy Practice, 2011
Objectives: This study aimed to explore how well Victorian pharmacists perceived they understood pharmacogenetics, their perceived capacity to counsel a patient about such testing, how they believed pharmacogenetics would impact upon their profession ...
McMahon T, Tucci J
doaj  

The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids

Cells, 2023
Connective tissue growth factor (CTGF) is involved in the regulation of extracellular matrix (ECM) production. Elevated levels of CTGF can be found in plasma from patients with liver fibrosis and in experimental animal models of liver fibrosis, but the ...
Sara Redenšek Trampuž, Sander van Riet, Åsa Nordling, Magnus Ingelman-Sundberg   +3 more
doaj   +1 more source

Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability [PDF]

, 2013
Background: The need for new malaria surveillance tools and strategies is critical, given improved global malaria control and regional elimination efforts.
Abdullah S Ali, Anders Björkman, Andreas Mårtensson, Berit Aydin-Schmidt, Delér Shakely, DS Ishengoma, E Kamau, G Froberg, G Holmgren, G Snounou, J Hwang, José P Gil, L Cnops, LC Okell, Louise Jörnhagen, Max Petzold, MI Veiga, Mwinyi I Msellem, N Steenkeste, Pedro E Ferreira, RN Price, S Bereczky, S Dahlstrom, SA Greenspoon, SE Shokoples, Ulrika Morris, V Veron   +26 more
core   +2 more sources