Results 91 to 100 of about 34,942 (245)
The promise and challenges of pharmacogenomics in psychiatry [PDF]
Pharmacogenomics (PGx) is an expanding field within precision medicine that is poised to play a crucial role in optimising patient outcomes, particularly in the realm of psychiatry.
Cyrus Su Hui Ho +2 more
core +1 more source
PLoS Computational Biology, 2012 There is great variation in drug-response phenotypes, and a "one size fits all" paradigm for drug delivery is flawed. Pharmacogenomics is the study of how human genetic information impacts drug response, and it aims to improve efficacy and reduced side ...
Konrad J Karczewski +3 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen +9 more
wiley +1 more source
Genetic Determinants of Treatment‐Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia
Clinical Pharmacology &Therapeutics, EarlyView.Osteonecrosis and fractures are serious corticosteroid‐induced bone toxicities in children treated for acute lymphoblastic leukemia, yet their genetic determinants remain incompletely defined. In this study, we aimed to identify novel genetic contributors to bone toxicity and to evaluate the robustness of both newly identified and previously ...
Rachid Abaji +14 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear +16 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is commonly used for secondary prevention following acute ischemic stroke (AIS) and neurointerventional procedures. However, the efficacy of clopidogrel is reduced in carriers of CYP2C19 no‐function alleles.
Rachael M. Stone +11 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó +7 more
wiley +1 more source
Analyzing array data using supervised methods [PDF]
, 2002 Pharmacogenomics is the application of genomic technologies to drug discovery and development, as well as for the elucidation of the mechanisms of drug action on cells and organisms. DNA microarrays measure genome-wide gene expression patterns and are an
Peterson, Carsten, +5 more
core +1 more source
Developments in pharmacogenetics, pharmacogenomics, and personalized medicine
Pharmacological ResearchThe development of Pharmacogenetics and Pharmacogenomics in Western Europe is highly relevant in the worldwide scenario. Despite the usually low institutional support, many research groups, composed of basic and clinical researchers, have been actively ...
Francisco Abad-Santos +6 more
doaj +1 more source
Frontiers in Pharmacology, 2016 Acute lymphoblastic leukemia (ALL) is a frequent neoplasia occurring in children. The most commonly used drug for the treatment of ALL is methotrexate (MTX), an anti-folate agent.
Fausto Zaruma-Torres +9 more
doaj +1 more source