Results 111 to 120 of about 38,200 (304)

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, EarlyView.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

DEMOGRAPHIC SURVEY REGARDING PERCEPTION AND IMPLEMENTATION OF PHARMACOGENOMICS AMONG GRADUATING PHARMACIST AND PROFESSIONALS IN KARACHI, PAKISTAN

FUUAST Journal of Biology
Patient responses to the drugs are highly influential by their genes, called pharmacogenomics, therefore, gene personalized therapy regulating more efficiently the side effects and drug efficacy, individually. For the coupling of pharmacogenomics to the
BUSHRA HINA, SAMAN USMANI, KIRAN RAFIQ
doaj  

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Pharmacogenomics in osteoporosis: Steps toward personalized medicine

, 2009
Robert Greene1, Shaymaa S Mousa, Mohamed Ardawi2, Mohamed Qari2, Shaker A Mousa11The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USA; 2Center of Excellence in Osteoporosis Research, King Abdul Aziz ...
Mohamed Ardawi, Shaymaa S Mousa, et al, Robert Greene   +3 more
core  

Pharmacogenomics in the Evaluation of Efficacy and Adverse Events During Clinical Development of Vaccines

, 2008
The understanding of vaccine-induced immune responses in adults and infants is limited. Current vaccination schedules for infants are frequently debated. Especially, the relationship among the timing, the frequency of the dosing, and the generation of an
Nilsson, Lennart,, Regnström, Karin J.,, Lennart J. Nilsson, Karin J. Regnström, Regnström, K.J.,   +4 more
core   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Developments in pharmacogenetics, pharmacogenomics, and personalized medicine

Pharmacological Research
The development of Pharmacogenetics and Pharmacogenomics in Western Europe is highly relevant in the worldwide scenario. Despite the usually low institutional support, many research groups, composed of basic and clinical researchers, have been actively ...
Francisco Abad-Santos, Salvador F. Aliño, Alberto M. Borobia, Elena García-Martín, Patricia Gassó, Olalla Maroñas, José A.G. Agúndez   +6 more
doaj   +1 more source

Pharmacogenomics of sickle cell disease: steps toward personalized medicine

, 2017
Marium Husain,1 Amber D Hartman,2 Payal Desai3 1Division of Medical Oncology, 2Division of Palliative Medicine, 3Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA Abstract: Sickle cell disease (SCD) is a ...
Desai P, Hartman AD, Husain M
core  

Analyzing array data using supervised methods

, 2002
Pharmacogenomics is the application of genomic technologies to drug discovery and development, as well as for the elucidation of the mechanisms of drug action on cells and organisms. DNA microarrays measure genome-wide gene expression patterns and are an
Peterson, Carsten,, Ringnér, Markus,, Khan, J, Khan, J,, Peterson, Carsten, Ringnér, Markus   +5 more
core   +1 more source