Results 131 to 140 of about 39,211 (299)

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

Analyzing array data using supervised methods

, 2002
Pharmacogenomics is the application of genomic technologies to drug discovery and development, as well as for the elucidation of the mechanisms of drug action on cells and organisms. DNA microarrays measure genome-wide gene expression patterns and are an
Peterson, Carsten,, Ringnér, Markus,, Khan, J, Khan, J,, Peterson, Carsten, Ringnér, Markus   +5 more
core   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Contemporary pharmacogenetic assays in view of the PharmGKB database

, 2019
Aim: Six modern PGx assays were compared with the Pharmacogenomics Knowledge Base (PharmGKB) to determine the proportion of the currently known PGx genotypes that are assessed by these assays.
Deforce, Dieter, Weymaere, Jana0001203115248020026650119190267756400000-0002-8213-1973C81B15F8-F0EE-11E1-A197-91C894A0A6B4, Weymaere, Jana, Van Nieuwerburgh, FilipFW010019944544838010013358290000-0001-8815-5485F5BC58D8-F0ED-11E1-A9DE-61C894A0A6B4, Tilleman, LaurentijnDI040001100597358020023900740000-0001-7584-117933C35672-F0EE-11E1-A9DE-61C894A0A6B4, Heindryckx, BjörnGE38UZGent0019942807928010013427010000-0003-0630-8420F5C0698C-F0ED-11E1-A9DE-61C894A0A6B4, Deforce, DieterFW010019890795728010009626800000-0002-0635-661XF4D02620-F0ED-11E1-A9DE-61C894A0A6B4, Tilleman, Laurentijn, Heindryckx, Björn, Van Nieuwerburgh, Filip   +9 more
core   +1 more source

Medication Use and Risk of Microscopic Colitis: A Propensity‐Matched Analysis of US Adults ≥ 50 Years (2014–2024)

Alimentary Pharmacology &Therapeutics, EarlyView.
Commonly prescribed NSAIDs, PPIs and SSRIs were associated with a higher risk of microscopic colitis after propensity score matching, whereas ACE inhibitors, ARBs and statins showed no significant association. ABSTRACT Background The association between medications—including non‐steroidal anti‐inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs ...
Yassine Kilani, Farah Heis, Andrew Dugaesescu, Youssef Hafez, Shadi Hamdeh, Wissam Kiwan, Mahmoud Y. Madi   +6 more
wiley   +1 more source

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Discover Oncology
Background Metastasis, the spread of cancer cells from the primary tumor to distant organs, is the leading cause of mortality in cancer patients. This process often exhibits a preference for specific organs, a phenomenon known as tumor organotropism ...
Meizhu Xiao, Zhijin Fu, Yanjiao Li, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie   +8 more
doaj   +1 more source

Addressing Ancestry and Sex Bias in Pharmacogenomics

The association of an individual's genetic makeup with their response to drugs is referred to as pharmacogenomics. By understanding the relationship between genetic variants and drug efficacy or toxicity, we are able to optimize pharmacological therapy ...
Corpas, Manuel, Mathur, Rohini, Soremekun, Opeyemi, Fatumo, Segun, Siddiqui, Moneeza K., Gill, Dipender   +5 more
core   +1 more source

Building a precision therapeutics program at a tertiary care children's hospital

Pediatric Investigation, EarlyView.
Luke Hamilton, Heidi Trinkman, Diana Carrasco, Kaitlin Smith, Kelly Vallance, Alejandra Dominguez, Danielle Miller, Megan Gibbs, Anish Ray   +8 more
wiley   +1 more source

Paediatric haematopoietic stem cell transplantation research priorities: Results from an international multi‐stakeholder priority setting partnership

British Journal of Haematology, EarlyView.
Summary Co‐designed research in paediatric HSCT is limited. We sought to determine research priorities which represent the shared priorities of patients, parents, carers and healthcare professionals (HCP) within Australia, New Zealand, the Netherlands and the United Kingdom.
Elizabeth Williams, Roxanne Dyas, Katherine Colman, Suzannah Kinsella, Amanda Gwee, Amy Lovell, Andrew R. Gennery, Mary Slatter, Lori Chait‐Rubinek, Eileen Van Der Stoep, Arjan Lankester, Hilda Mekelenkamp, Ben Gelbart, Karen Nicholson, Lorna McLeman, Shivanthan Shanthikumar, Vanessa Clifford, Theresa Cole, Gabrielle M. Haeusler, Lisa M. Ott de Bruin, Tim Prestidge, Adam Nelson, Kanchan Rao, Rachel Conyers, on behalf of the James Lind Alliance Priority Setting Partnership in Paediatric Haematopoietic Stem Cell Transplantation Steering Committee   +24 more
wiley   +1 more source

The association between white blood cell count and relative risk of non-small cell lung cancer

Discover Oncology
Background High abundance of eosinophils has been proved to associated with favorable disease progression in non-small cell lung cancer (NSCLC) in the previous observational studies, but the causal relationship remains unclear. It is also unclear whether
Xiao Yang, Wenyi Liu, Jiaqi Wang, Weifeng Xia, Lanxiang Wu   +4 more
doaj   +1 more source