Results 151 to 160 of about 38,200 (304)

Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC

Journal of Nanobiotechnology
High-grade serous ovarian carcinoma (HGSOC) remains a lethal malignancy with few effective therapeutic options. In this study, we systematically evaluated the anti-tumor effect of Bi2536, an inhibitor of Polo-like kinase 1 (PLK1), in HGSOC, and clarified
Xue Zhou, Yutang Huang, Chenyi Li, Wenlu Mo, Weifeng Xia, Ruiqin Du, Lanxiang Wu, Hongbo Zhao   +7 more
doaj   +1 more source

CYP2D6 Metabolizer Status and Mortality in Metoprolol Users. [PDF]

Clin Transl Sci
ABSTRACT Numerous pharmacogenomic (PGx) associations of pharmacokinetics and pharmacodynamics of commonly prescribed medications have been reported. Yet, the evidence supporting their association on survival remains underexamined. We sought to investigate the CYP2D6‐metoprolol association and determine whether the established variability in drug ...
de Denus S, Oussaïd E, Meloche M, Bertrand AX, Leclair G, Cyr MC, Jutras M, Gaulin MJ, Mongrain I, Busseuil D, Tardif JC, Dubé MP.   +11 more
europepmc   +2 more sources

Integrated Transcriptomics of Human and Canine Osteosarcoma Reveals Species Stemness and Trabectedin Sensitivity

Cancer Science, EarlyView.
Comprehensive comparative molecular framework for human and canine osteosarcomas. Integrated transcriptomic analyses establish a comprehensive comparative molecular framework for human and canine osteosarcomas. By defining species‐specific stemness architectures and drug response dynamics, our findings highlight the necessity of accounting for distinct
Kenta Kono, Yomogi Shiota, Ting‐Ting Shu, Hayato Shibahara, Daiki Kato, Takayuki Nakagawa, Seiji Ohtori, Tadashi Kondo   +7 more
wiley   +1 more source

Investigation of community pharmacists’ knowledge and attitudes of pharmacogenomics testing: implication for improved pharmacogenomic testing practice

Human Genomics
Background Community pharmacists must be well-equipped to advance pharmacogenomics services. Nevertheless, limited data is available regarding pharmacists' knowledge and attitudes toward pharmacogenomics testing.
Azza Ramadan, Anan S. Jarab, Ahmad Z. Al Meslamani   +2 more
doaj   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Pharmacogenomics and Big Data in medical oncology: developments and challenges

Therapeutic Advances in Medical Oncology
Medical oncology, through conventional chemotherapy as well as targeted drugs, remains an important component of cancer patient management, particularly for systemic disease.
Loredana G. Marcu, David C. Marcu
doaj   +1 more source

Per Med [PDF]

AimTo describe the knowledge and attitudes of clinicians participating in a large pharmacogenomics implementation program.Materials & methodsSemi-structured interviews with 15 physicians and nurse practitioners were conducted.ResultsThree categories of ...

core  

Genetic and Clinical Determinants of Variation in Drug Response in Type 2 Diabetes: Insights From the Scottish and UK Biobank Cohorts

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
S. Garg, R. Kitchen, R. Gupta, L. Donnelly, E. R. Pearson   +4 more
wiley   +1 more source

Variations in the Wnt/β-catenin pathway key genes as predictors of cervical cancer susceptibility [corrigendum] [PDF]

, 2020
Pharmacogenomics and Personalized Medicine
core   +1 more source

Personalized medicine in breast cancer: pharmacogenomics approaches

, 2019
Shabnam Jeibouei,1 Mohammad Esmael Akbari,2 Alireza Kalbasi,3 Amir Reza Aref,4,5 Mohammad Ajoudanian,6 Alireza Rezvani,7 Hakimeh Zali81Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical ...
Zali H, Jeibouei S, Aref AR, Akbari ME, Ajoudanian M, Kalbasi A, Rezvani A   +6 more
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