Results 141 to 150 of about 38,200 (304)

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Discover Oncology
Background Metastasis, the spread of cancer cells from the primary tumor to distant organs, is the leading cause of mortality in cancer patients. This process often exhibits a preference for specific organs, a phenomenon known as tumor organotropism ...
Meizhu Xiao, Zhijin Fu, Yanjiao Li, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie   +8 more
doaj   +1 more source

Pharmacogenomic curriculum in Australian medical schools: a content analysis study. [PDF]

AIMS: To ascertain and describe pharmacogenomic concepts included in the intended curriculum of accredited Australian medical schools. METHODS: Content analysis of curriculum learning objectives of Australian medical schools was conducted, focusing on ...
Freeman, CR, Kryzyaniak, N, Thomas, J, Yong, FR, Noble, C   +4 more
core   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

The association between white blood cell count and relative risk of non-small cell lung cancer

Discover Oncology
Background High abundance of eosinophils has been proved to associated with favorable disease progression in non-small cell lung cancer (NSCLC) in the previous observational studies, but the causal relationship remains unclear. It is also unclear whether
Xiao Yang, Wenyi Liu, Jiaqi Wang, Weifeng Xia, Lanxiang Wu   +4 more
doaj   +1 more source

Practical recommendations for pharmacogenomics - based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics

, 2011
The present article summarizes the discussions of the 3rd European Science Foundation University of Barcelona (ESF-UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain.
Ron HN van Schaik, van Schaik, Ron H. N., Somogyi, Andrew A., van Kuilenburg, André B. P., K Daly, Ann, Evelyne Jacqz-Aigrain, Hiltrud Brauch, Jacqz-Aigrain, Evelyne, Andrew A Somogyi, Becquemont, Ana, A Somogyi, Andrew, Anke-Hilse Maitland-van der Zee, van Schalk, Ron, Schwab, Matthias, Niemi, Mikko, Thervet, Eric, Amstutz, Ursula, Molina, Miguel A., A Molina, Miguel, Mia Wadelius, Matthias Schwab, Miguel A Molina, Ann K Daly, Brauch, Hiltrud, Laurent-Puig, Pierre, Laurent Becquemont, Ana Alfirevic, Céline Verstuyft, van Kuilenburg, André, Daly, Ann K., Verstuyft, Céline, Alfirevic, Ana, Mikko Niemi, Eric Thervet, Pierre Laurent-Puig, Wadelius, Mia, Ursula Amstutz, Becquemont, Laurent, André BP van Kuilenburg, Maitland-van der Zee, Anke-Hilse   +39 more
core   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Pharmacogenomics in cardiovascular disorders: Steps in approaching personalized medicine in cardiovascular medicine [PDF]

, 2009
Christopher Barone, Shaymaa S Mousa, Shaker A MousaThe Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USAAbstract: Some of the most commonly prescribed medications are those for cardiovascular maladies. The
Christopher Barone, Shaymaa S Mousa, Shaker A Mousa   +2 more
core  

Machine Learning‐Derived Immune Gene Signature Predicts Prognosis and Therapeutic Vulnerabilities in Multiple Myeloma

Cancer Science, EarlyView.
An immune‐related 12‐gene signature developed through integrative machine learning stratified overall survival across multiple myeloma cohorts and remained independently associated with outcome. Single‐cell, somatic mutation, and transcriptome‐based drug‐response analyses further linked the signature to multicellular bone marrow context, distinct ...
Kai Wang, Chenfei Zhao, Jingru Shi, Shiwei Liu, Yi Chen, Jujuan Wang, Zhengxu Sun, Sanmei Wang, Lei Fan, Jin Fan, Xiaoyan Qu   +10 more
wiley   +1 more source

Building a precision therapeutics program at a tertiary care children's hospital

Pediatric Investigation, EarlyView.
Luke Hamilton, Heidi Trinkman, Diana Carrasco, Kaitlin Smith, Kelly Vallance, Alejandra Dominguez, Danielle Miller, Megan Gibbs, Anish Ray   +8 more
wiley   +1 more source