Results 231 to 240 of about 39,211 (299)

Amplicon-based long-read sequencing for accurate CYP2D6 gene deletion and duplication detection using CYP2D7 as a reference gene. [PDF]

Pharmacogenomics J
Tesfamicael KG, Musker M, Adelson DL, Lewis MD.   +3 more
europepmc   +1 more source

Network Biology: Current Status, Applications, Challenges, and Future Prospects

MedComm, Volume 7, Issue 10, October 2026.
Network biology integrates molecular interaction, intracellular regulatory, single‐cell and multicellular, microbial and host–microbiome, disease, and interorgan networks across biological scales. Perturbation models, multiomics, spatial profiling, computational inference, mechanistic modeling, and AI enable dynamic network reconstruction and causal ...
Xinmeng Li, Laizhong Zhang, Yawen Ding, Kai Li, Shiyuan Chang, Linsen Pei, Zhengwei Li, Zhenzhen Chen   +7 more
wiley   +1 more source

Financing and health system capacity for precision medicine in Asia: a six country landscape analysis. [PDF]

Health Aff Sch
Peh ALT, Teerawattananon Y, Yuen JXY, Charafi N, Tahapary DL, Leng J, Morton A, Li S, Kim WJ, Zilfalil BA, Hasbullah HH, Satproedprai N, Li ST, Ngeow JYY, Juang YR, Zhang Y, Hong M, Chen W.   +17 more
europepmc   +1 more source

Association Between CYP2C19 Genotype and P2Y12 Reaction Units in Patients Receiving Clopidogrel After Acute Ischemic Stroke: A Prospective, Observational Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Recurrent stroke accounts for substantial morbidity and mortality worldwide, with up to 25% of ischemic strokes occurring in patients with prior strokes. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard for secondary prevention after minor acute ischemic stroke (AIS) or high‐risk transient ischemic attack ...
Rachael M. Stone, Annie Smith, Sonya Gunter, Andrew T. Weko, Carter Gottschalk, Cheyenne Lee, Allison Ramsey, Miah Perch Weatherspoon, Bradford B. Worrall   +8 more
wiley   +1 more source

The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review. [PDF]

Int J Mol Sci
Mercadante S.
europepmc   +1 more source

Concurrent Antidepressant Use and Metastasis Risk Among Women Receiving Tamoxifen for Breast Cancer: A Real‐World Cohort Study

Psycho-Oncology, Volume 35, Issue 10, October 2026.
ABSTRACT Objective Concurrent use of antidepressants, particularly cytochrome P450 2D6 (CYP2D6) inhibitors, may reduce tamoxifen bioactivation and effectiveness. However, the clinical significance of this potential interaction remains inconclusive. This study examined whether concurrent antidepressant use is associated with increased metastasis risk ...
Shaimaa Elshafie, Mohammed Zuber, Ainhoa Gomez‐Lumbreras, Daniel C. Malone, Lorenzo Villa Zapata   +4 more
wiley   +1 more source

Correction: Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy. [PDF]

J Nanobiotechnology
Fang M, Cao L, Zhang Z, Yu Z, Shen Y, Chen J, Chen J, Li YQ, Liu Z, Meng Y, Xiao H, Qu Q, Yin JY, Li XP.   +13 more
europepmc   +1 more source

A Cohort Study on Incidence and Factors Associated With Adverse Drug Reactions of Enalapril in Lusaka, Zambia

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Angiotensin‐converting enzyme inhibitors (ACEIs) are widely prescribed but are associated with adverse drug reactions (ADR), including angioedema, which is typically reported in 0.1%–0.7%. Data from sub‐Saharan Africa are limited. This study aimed to estimate the incidence and risk factors of enalapril‐associated ADRs in a Zambian cohort, with
Ntemena Yikon'a, Ngosa Mumba, Sarah Pedretti, Helen Hoenck, Jonathan Peter, Owen Ngalamika   +5 more
wiley   +1 more source

Population Pharmacokinetics of Dolutegravir in Plasma and Cerebrospinal Fluid in Adults Living With HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Characterizing dolutegravir penetration into the central nervous system is important for optimizing human immunodeficiency virus treatment outcomes, yet population‐specific pharmacokinetic data describing cerebrospinal fluid disposition and equilibration kinetics remain lacking.
Mohammed W. Ali, Sam Nightingale, Tracy Kellermann, John Joska, Alan Winston, Saye Khoo, Joseph F. Standing, Eric H. Decloedt, Ahmed A. Abulfathi   +8 more
wiley   +1 more source

Rome V Criteria for Adults: What's New and Why?

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT The Rome V criteria, published in 2026, represent the culmination of a 7‐year effort to refine and improve the diagnostic framework for disorders of gut–brain interaction. The revision incorporates the latest consensus guidelines and emerging research while moving away from stigmatizing language and toward a more personalized, patient‐centered
Amanda Krause, Lin Chang
wiley   +1 more source