Results 221 to 230 of about 38,200 (304)

Financing and health system capacity for precision medicine in Asia: a six country landscape analysis. [PDF]

Health Aff Sch
Peh ALT, Teerawattananon Y, Yuen JXY, Charafi N, Tahapary DL, Leng J, Morton A, Li S, Kim WJ, Zilfalil BA, Hasbullah HH, Satproedprai N, Li ST, Ngeow JYY, Juang YR, Zhang Y, Hong M, Chen W.   +17 more
europepmc   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review. [PDF]

Int J Mol Sci
Mercadante S.
europepmc   +1 more source

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age‐Related Fluoxetine Accumulation in the Elderly

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT This study quantified age‐related differences in fluoxetine pharmacokinetics and evaluated the influence of CYP2D6 phenotype using physiologically based pharmacokinetic (PBPK) modeling integrated with clinical therapeutic drug monitoring data.
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Precision Dosing of Tacrolimus in Liver Transplantation: Integrating Donor‐Recipient CYP3A5 Pharmacogenomics and Drug Interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Tacrolimus dosing in liver transplantation is complicated by a narrow therapeutic index and high CYP3A5 genetic variability. While saturable Michaelis–Menten kinetics can explain nonlinearities, identifying saturable parameters from routine clinical data remains challenging.
Virunya Komenkul, Prawat Chantharit, Piyawat Komolmit, Bunthoon Nonthasoot, Athaya Vorasittha, Anapat Sanpavat, Sirinporn Suksawatamnuay, Chandramouli Radhakrishnan, Thitima Wattanavijitkul   +8 more
wiley   +1 more source

Clinical Pharmacology at the Point of Decision. [PDF]

Clin Pharmacol Ther
Elmeliegy M, McIntosh A.
europepmc   +1 more source

“Yet the Problem Remains”: Why Genetic Determinism Still Haunts Biomedical Research

Bioethics, Volume 40, Issue 7, Page 658-666, September 2026.
ABSTRACT After the horrors of the Holocaust and its connections to eugenics were revealed to the world, many post‐war population geneticists sought to establish rhetorical distance from the Nazi's state‐led campaigns, without abandoning their belief that actively shaping the population's genetics would produce a prosperous society.
Christopher R. Donohue, Ian A. Myles
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Development of a New Portable Genetic Analyzer for Point-of-Care Molecular Genetics and Pharmacogenomics Analysis. [PDF]

Hum Mutat
Poulida I, Karamperis K, Routsi IK, Sarris I, Mantzouranis G, Kostopoulos V, Mitropoulou C, Patrinos GP.   +7 more
europepmc   +1 more source

Baxdrostat as a catalyst for precision hypertension: integrating pharmacogenomics, omics biomarkers, and digital phenotyping in resistant hypertension management. [PDF]

Clin Hypertens
Amjad A, Batool ST, Ali U.
europepmc   +1 more source