Results 61 to 70 of about 67,526 (234)

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Pharmacogenomics : tailoring drug therapy to individual patients

Journal de la Faculté de Médecine d'Oran
Pharmacogenomics, the study of how individual genetic variations influence drug response, holds tremendous potential for personalized medicine. This comprehensive literature review explores the current landscape of pharmacogenomics, focusing on its role
Eskandar KIROLOS Kirolos
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Evaluating Perceived Value of Pharmacogenomic Testing After a Personalized Therapeutics Clinic Consultation. [PDF]

Clin Transl Sci
ABSTRACT Pharmacogenomics (PGx) offers patients personalized treatment by guiding medication selection and dosing based on their genetic profiles. However, widespread clinical implementation remains limited, in part due to patient and provider concerns about cost and willingness to pay (WTP).
Chen T, Andriessen AS, Jack M, George D, House LK, Chan C, Yeo KJ, Ratain MJ, O'Donnell PH.   +8 more
europepmc   +2 more sources

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Precision medicine in pharmacy: assessing pharmacogenomics competence among pharmacists and pharmacy students

Journal of Pharmaceutical Policy and Practice
Background Pharmacogenomics, a key component of precision medicine, aims to improve healthcare outcomes. As pharmacists play a pivotal role in this evolving field, an assessment of their preparedness to apply pharmacogenomics is imperative.Methods In ...
Mohanad Odeh, Lana Sbitan, Noor Alzraikat, Haneen Tanous, Tarik Al-Diery   +4 more
doaj   +1 more source

Clinical Knowledge, Attitude, and Perceptions of Community Pharmacists Towards Pharmacogenomics - A Cross-Sectional Study from Saudi Arabia

Pharmacogenomics and Personalized Medicine, 2023
Ziyad Alrabiah, Wajid Syed, Salmeen D Babelghaith, Mohamed N Al Arifi Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi ArabiaCorrespondence: Wajid Syed, Email wali@ksu.edu.saBackground and Aims: It is ...
Alrabiah Z, Syed W, Babelghaith SD, Al Arifi MN   +3 more
doaj  

Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods

Nature Communications, 2022
To try to predict an individual’s drug response using genetic data, most studies have used traditional polygenic risk score (PRS) methods. Here, the authors develop a pharmacogenomics-specific PRS method, which can improve drug response prediction and ...
Song Zhai, Hong Zhang, Devan V. Mehrotra, Judong Shen   +3 more
doaj   +1 more source

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]

, 2017
Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R., Chondrou, Vasiliki, John, Anne, Kastrinou, Vlasia, Katsila, Theodora, Kolovos, Petros, Kourakli, Alexandra, Papachatzopoulou, Adamantia, Patrinos, George P., Pavlidaki, Alexia, Sgourou, Argyro, Symeonidis, Argiris   +11 more
core   +5 more sources