Results 41 to 50 of about 38,200 (304)

Implementing Cytochrome P450 Pharmacogenomics in Clinical Practice: A Glimmer of Hope or Simply a Mirage? [PDF]

ERU Research Journal
Even though pharmacogenomics approaches are becoming progressively more advanced, opinions on their clinical validity and implementation remain controversial.
Mohammed Maslub, Mahasen Radwan, Abubakar Shaaban, Nur Aizati Daud   +3 more
doaj   +1 more source

Pharmacogenomics Implementation Across Multiple Clinic Settings: A Qualitative Evaluation

, 2023
Aim: To advance clinical adoption and implementation of pharmacogenomics (PGx) testing, barriers and facilitators to these efforts must be understood. This study identified and examined barriers and facilitators to active implementation of a PGx program ...
Rowe, Elizabeth, Shue, Sarah A., Gowan, Tayler, Bell, Lauren A., Skaar, Todd, Damush, Teresa, DeLong, Alexis, Haggstrom, David   +7 more
core   +1 more source

Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow

Frontiers in Pharmacology, 2019
Pharmacogenomics has been recognized as a fundamental tool in the era of personalized medicine with up to 266 drug labels, approved by major regulatory bodies, currently containing pharmacogenomics information. Next-generation sequencing analysis assumes
Efstathia Giannopoulou, Theodora Katsila, Christina Mitropoulou, Evangelia-Eirini Tsermpini, George P. Patrinos, George P. Patrinos, George P. Patrinos   +6 more
doaj   +1 more source

Knowledge, attitude, perception, and self-reported confidence of community pharmacists towards pharmacogenomics services

Journal of Pharmaceutical Policy and Practice
Background Pharmacogenomics is used to optimise patient drug therapy. The role of community pharmacists in the implementation of pharmacogenomics services is emerging. This study evaluated the knowledge, attitude, perception, and self-reported confidence
Usman Abubakar, Lienarrubini Subramaniam, Amer Hayat Khan   +2 more
doaj   +1 more source

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study [PDF]

, 2020
OBJECTIVES: Pharmacogenetic panel-based testing represents a new model for precision medicine. A sufficiently powered prospective study assessing the (cost-)effectiveness of a panel-based pharmacogenomics approach to guide pharmacotherapy is lacking ...
Ubiquitous Pharmacogenomics Consortium
core  

Distinct expression profiles and functions of Kindlins in breast cancer

Journal of Experimental & Clinical Cancer Research, 2018
Background Kindlin-1, − 2, and − 3 are the three members of the Kindlin family. They are best known as regulators of integrin functions, contributing to fundamental biological processes such as cell survival, adhesion and migration.
Paula Azorin, Florian Bonin, Ahmad Moukachar, Aurélie Ponceau, Sophie Vacher, Ivan Bièche, Elisabetta Marangoni, Laetitia Fuhrmann, Anne Vincent-Salomon, Rosette Lidereau, Keltouma Driouch   +10 more
doaj   +1 more source

Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays

Scientific Reports, 2021
Single-nucleotide polymorphisms (SNPs) are the most common genetic variations for various complex human diseases, including cancers. Genome-wide association studies (GWAS) have identified numerous SNPs that increase cancer risks, such as breast cancer ...
Nurul Ain Khoruddin, Mohd NurFakhruzzaman Noorizhab, Lay Kek Teh, Farida Zuraina Mohd Yusof, Mohd Zaki Salleh   +4 more
doaj   +1 more source

Construction of a femininity score in the UK Biobank and its association with angina diagnosis prior to myocardial infarction

Scientific Reports, 2022
Gender captures social components beyond biological sex and can add valuable insight to health studies in populations. However, assessment of gender typically relies on questionnaires which may not be available.
Anna Levinsson, Simon de Denus, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Joëlle Rouleau, Jean-Claude Tardif, Julie Hussin, Marie-Pierre Dubé   +7 more
doaj   +1 more source

African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa [version 1; peer review: 2 approved]

AAS Open Research, 2019
The African Pharmacogenomics Consortium (APC) was formally launched on the 6th September 2018. This white paper outlines its vision, and objectives towards addressing challenges of conducting and applying pharmacogenomics in Africa and identifies ...
Collet Dandara, Collen Masimirembwa, Yosr Z. Haffani, Bernhards Ogutu, Jenniffer Mabuka, Eleni Aklillu, Oluseye Bolaji, H3Africa   +7 more
doaj   +1 more source

Classical twin design in modern pharmacogenomics studies.

, 2020
Response to medication is highly variable, unpredictable and, at times, may be fatal. All drugs are more effective in certain groups of the population while showing no or minimal benefit in other groups.
Rahmioğlu, N, Ahmadi, KR
core   +1 more source