Results 41 to 50 of about 39,211 (299)

Empowering precision medicine: Insights from a national survey on pharmacogenomics knowledge, attitudes, and perceptions among community pharmacists in the UAE

Exploratory Research in Clinical and Social Pharmacy
Background: Community pharmacists are essential to pharmacogenomics implementation because they can help trainers, clinical advisors, and other medical professionals understand the importance of pharmacogenomics and encourage them to use it in their ...
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Mena Al-Ani, Mustafa Aal Yaseen, Mahmood H. Al-Aawad, Ghala Rashid Alnuaimi, B. Mahalakshmi   +7 more
doaj   +1 more source

Relevance of pharmacogenomics for developing countries in Europe : implementation in the Maltese population [PDF]

, 2012
Pharmacogenomics is a promising new discipline that can realize personalized treatment for patients suffering from many common diseases, particularly those with multiple treatment modalities.
Mitropoulou, Christina, Borg, Joseph J., Vozikis, Athanassios, Patrinos, George P., Grech, Godfrey, Mitropoulos, Konstantinos, Fenech, Anthony G.   +6 more
core  

Pharmacogenomics: Personalized Drug Prescriptions Based on Genetics

, 2023
Pharmacogenomics, a rapidly advancing field at the intersection of genomics and pharmacology, has revolutionized the way we approach drug therapy. This paper explores the exciting developments in pharmacogenomics, focusing on how genetic information is ...
Jadbila Kaisanesh
core   +1 more source

Pharmacogenomics and personalized medicine [PDF]

, 2020
Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia,
Erika Cecchin, Gabriele Stocco, Stocco G., Cecchin E.   +3 more
core   +2 more sources

Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery

Advanced Science, EarlyView.
DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong, Ji Li, Mu Su, Peishen Yu, Te Ma, Ruiyang Zhai, Chenye Zhang, Mengyan Zhang, Yan Zhang   +8 more
wiley   +1 more source

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX

BMC Biology, 2018
Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis, Rosette Lidereau, François Lallemand, Keltouma Driouch   +18 more
doaj   +1 more source

Cardiovascular Pharmacogenomics

, 2017
Background: Variability in response to pharmacological treatment is one of the most important issues in the clinical practice at first exclusively attributed to clinical and demographic factors such as age, sex, nutritional status, alcohol abuse, smoking,
FILIPPELLI, Amelia, MANZO, VALENTINA, COSTANTINO, Maria, Amelia Filippelli, Maria Costantino, IANNACCONE, TERESA, Walter Filippelli, Filippelli, Walter, Valentina Manzo, Teresa Iannaccone, Sara Tarallo, Tarallo, Sara   +11 more
core   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases

Cancer Cell International, 2023
Background Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases (mCLM) and matched non-malignant ...
Lucie Heczko, Viktor Hlaváč, Petr Holý, Pavel Dvořák, Václav Liška, Ondřej Vyčítal, Ondřej Fiala, Pavel Souček   +7 more
doaj   +1 more source

Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward

, 2018
Successfully implementing pharmacogenomics into routine clinical practice requires an efficient process to order genetic tests and report the results to clinicians and patients.
Caudle, Kelly E., Klein, Teri E., Keeling, Nicholas J., Pratt, Victoria M., Hoffman, James M., Whirl-Carrillo, Michelle   +5 more
core   +1 more source