Results 41 to 50 of about 34,942 (245)

Pharmacogenomics perspective for forensic toxicology: A mini review

Medicine Science, 2022
Pharmacogenetic and Pharmacogenomics are the study of the association between an individual's genotype and their response to xenobiotics Pharmacokinetic and pharmacodynamics variations can appear at the level of drug-metabolizing enzymes, drug ...
Dilek Battal, Emel Hulya Yukseloglu, Fehmi Burak Alkas, Seyhan Sahan Firat   +3 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Relevance of pharmacogenomics for developing countries in Europe : implementation in the Maltese population [PDF]

, 2012
Pharmacogenomics is a promising new discipline that can realize personalized treatment for patients suffering from many common diseases, particularly those with multiple treatment modalities.
Mitropoulou, Christina, Borg, Joseph J., Vozikis, Athanassios, Patrinos, George P., Grech, Godfrey, Mitropoulos, Konstantinos, Fenech, Anthony G.   +6 more
core  

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

The needs and gaps in pharmacogenomics knowledge and education among healthcare professionals in Malaysia: A multisite Delphi study

Clinical and Translational Science
Lack of pharmacogenomics knowledge among healthcare professionals is the most significant cited barrier to implementing pharmacogenomics in clinical settings.
Safa Omran, Siew Lian Leong, Ali Blebil, Devi Mohan, Wei Chern Ang, Siew Li Teoh   +5 more
doaj   +1 more source

Knowledge, Perception, and Application of Pharmacogenomics Among Hospital Pharmacists in Saudi Arabia

Risk Management and Healthcare Policy, 2020
Mohammed Algahtani Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi ArabiaCorrespondence: Mohammed Algahtani Email msalqahtane@nu.edu.saIntroduction: The accelerated transformation in the healthcare system ...
Algahtani M
doaj  

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Implementing health economics for pharmacogenomics research translation in Africa

Communications Medicine
Pharmacogenomics studies how a person’s inherited genes influence response to therapeutic drugs. Many drugs do not work in all patients and pharmacogenomics can assist in the identification of patients who are better suited to particular drugs or ...
Mohamed Zahir Alimohamed, George Dennis Obeng, Marcell Csanadi, Collen Masimirembwa, Collet Dandara   +4 more
doaj   +1 more source

Molecular Functions of WWOX Potentially Involved in Cancer Development

Cells, 2021
The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated
Karim Taouis, Keltouma Driouch, Rosette Lidereau, François Lallemand   +3 more
doaj   +1 more source