Pharmacogenomics decision support in the U-PGx project: Results and advice from clinical implementation across seven European countries. [PDF]
, 2022 BackgroundThe clinical implementation of pharmacogenomics (PGx) could be one of the first milestones towards realizing personalized medicine in routine care. However, its widespread adoption requires the availability of suitable clinical decision support
Turner, Richard M +42 more
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Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward [PDF]
, 2018 Successfully implementing pharmacogenomics into routine clinical practice requires an efficient process to order genetic tests and report the results to clinicians and patients.
Caudle, Kelly E. +5 more
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Pharmacogenomics of importance for paclitaxel chemotherapy [PDF]
, 2008 Paclitaxel (Taxol®) has a broad activity spectrum and is clinically used, often in combination with carboplatin, to treat breast, ovarian and lung cancer.
Green, Henrik
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Cardiovascular Pharmacogenomics [PDF]
, 2017 Background: Variability in response to pharmacological treatment is one of the most important issues in the clinical practice at first exclusively attributed to clinical and demographic factors such as age, sex, nutritional status, alcohol abuse, smoking,
FILIPPELLI, Amelia +11 more
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Pharmacogenomics in early-phase clinical development. [PDF]
, 2013 Pharmacogenomics (PGx) offers the promise of utilizing genetic fingerprints to predict individual responses to drugs in terms of safety, efficacy and pharmacokinetics.
Burt, Tal, Dhillon, Savita
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Implementing Cytochrome P450 Pharmacogenomics in Clinical Practice: A Glimmer of Hope or Simply a Mirage? [PDF]
ERU Research JournalEven though pharmacogenomics approaches are becoming progressively more advanced, opinions on their clinical validity and implementation remain controversial.
Mohammed Maslub +3 more
doaj +1 more source
Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow
Frontiers in Pharmacology, 2019 Pharmacogenomics has been recognized as a fundamental tool in the era of personalized medicine with up to 266 drug labels, approved by major regulatory bodies, currently containing pharmacogenomics information. Next-generation sequencing analysis assumes
Efstathia Giannopoulou +6 more
doaj +1 more source
Pharmacogenomics in chronic pain therapy: From disease to treatment and challenges for clinical practice [PDF]
, 2019 Pharmacogenomics (PGx) has emerged as an encouraging tool in chronic pain therapy. Genetic variations associated with drug effectiveness or adverse reactions (amitriptyline/nortriptyline/codeine/oxycodone/tramadol-CYP2D6, amitriptyline-CYP2C19 ...
De Moraes, Natália Valadares [UNESP] +3 more
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Distinct expression profiles and functions of Kindlins in breast cancer
Journal of Experimental & Clinical Cancer Research, 2018 Background Kindlin-1, − 2, and − 3 are the three members of the Kindlin family. They are best known as regulators of integrin functions, contributing to fundamental biological processes such as cell survival, adhesion and migration.
Paula Azorin +10 more
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Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study [PDF]
, 2020 OBJECTIVES: Pharmacogenetic panel-based testing represents a new model for precision medicine. A sufficiently powered prospective study assessing the (cost-)effectiveness of a panel-based pharmacogenomics approach to guide pharmacotherapy is lacking ...
Ubiquitous Pharmacogenomics Consortium
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