Results 21 to 30 of about 39,211 (299)
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling [PDF]
, 2014 Grazia Daniela Femminella,1 Vincenzo Barrese,2,3 Nicola Ferrara,1,4 Giuseppe Rengo4 1Department of Translational Medical Sciences, Federico II University, Naples, Italy; 2Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II
Ferrara, N +11 more
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Pharmacogenovigilance: a pharmacogenomics pharmacovigilance program [PDF]
, 2014 In this report, we review the importance of pharmacovigilance in detecting postmarketing adverse drug events and the potential for developing pharmacogenovigilance programs by integrating pharmacogenomics with pharmacovigilance.
Khoueiry-Zgheib, Nathalie, Awada, Zainab
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Pharmacogenomics of importance for paclitaxel chemotherapy [PDF]
, 2008 Paclitaxel (Taxol®) has a broad activity spectrum and is clinically used, often in combination with carboplatin, to treat breast, ovarian and lung cancer.
Green, Henrik, Green, Henrik,
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Physicians’ pharmacogenomics information needs and seeking behavior: a study with case vignettes
BMC Medical Informatics and Decision Making, 2017 Background Genetic testing, especially in pharmacogenomics, can have a major impact on patient care. However, most physicians do not feel that they have sufficient knowledge to apply pharmacogenomics to patient care. Online information resources can help
Bret S. E. Heale +4 more
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Pharmacogenomics, 2010 Irinotecan is a camptothecin analog used as an anticancer drug. Severe, potentially life-threatening toxicities can occur from irinotecan treatment. Although multiple genes may play a role in irinotecan activity, the majority of evidence to date suggests that variation in expression of UGT1A1 caused by a common promoter polymorphism (UGT1A1*28) is ...
Sharon, Marsh, Janelle M, Hoskins
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Cardiovascular pharmacogenomics
Experimental Physiology, 2005 There is large interpatient variability in the response to drugs, including cardiovascular drugs. Thus, while some patients achieve the desired therapeutic response from their drug therapy, others do not. There is also a subset of patients who will experience adverse effects, which can range from bothersome to life threatening. Research in recent years
Julie A, Johnson, Larisa H, Cavallari
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Seminars in Perinatology, 2020 Pregnant women frequently take prescription and over the counter medications. The efficacy of medications is affected by the many physiological changes during pregnancy, and these events may be further impacted by genetic factors. Research on pharmacogenomic and pharmacokinetic influences on drug disposition during pregnancy has lagged behind other ...
Hannah K, Betcher, Alfred L, George
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Implementing Cytochrome P450 Pharmacogenomics in Clinical Practice: A Glimmer of Hope or Simply a Mirage? [PDF]
ERU Research JournalEven though pharmacogenomics approaches are becoming progressively more advanced, opinions on their clinical validity and implementation remain controversial.
Mohammed Maslub +3 more
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Distinct expression profiles and functions of Kindlins in breast cancer
Journal of Experimental & Clinical Cancer Research, 2018 Background Kindlin-1, − 2, and − 3 are the three members of the Kindlin family. They are best known as regulators of integrin functions, contributing to fundamental biological processes such as cell survival, adhesion and migration.
Paula Azorin +10 more
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Pharmacogenomics in early-phase clinical development. [PDF]
, 2013 Pharmacogenomics (PGx) offers the promise of utilizing genetic fingerprints to predict individual responses to drugs in terms of safety, efficacy and pharmacokinetics.
Burt, Tal, Dhillon, Savita
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