Results 11 to 20 of about 67,526 (234)
Pharmacogenomic Biomarkers [PDF]
Disease Markers, 2002 Pharmacogenomic biomarkers hold great promise for the future of medicine and have been touted as a means to personalize prescriptions. Genetic biomarkers for disease susceptibility including both Mendelian and complex disease promise to result in improved understanding of the pathophysiology of disease, identification of new potential therapeutic ...
Kirkwood, Sandra C., Hockett, Richard D.
openaire +3 more sources
Pharmacogenomics of Antibiotics [PDF]
International Journal of Molecular Sciences, 2020 Although the introduction of antibiotics in medicine has resulted in one of the most successful events and in a major breakthrough to reduce morbidity and mortality caused by infectious disease, response to these agents is not always predictable, leading to differences in their efficacy, and sometimes to the occurrence of adverse effects.
Stocco G., Lucafo M., Decorti G.
openaire +4 more sources
Deciphering next-generation pharmacogenomics: an information technology perspective [PDF]
Open Biology, 2014 In the post-genomic era, the rapid evolution of high-throughput genotyping technologies and the increased pace of production of genetic research data are continually prompting the development of appropriate informatics tools, systems and databases as we ...
George Potamias +6 more
doaj +1 more source
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]
, 2014 Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V +3 more
core +2 more sources
Computational and Structural Biotechnology Journal, 2022 Background: Pharmacogenomics is crucial for individualized drug therapy and plays an increasingly vital role in precision medicine decision-making.
Xiaoyong Ge +10 more
doaj +1 more source
Platelet pharmacogenomics [PDF]
Journal of Thrombosis and Haemostasis, 2010 Platelet responsiveness to conventional antiplatelet therapy underlies a high interindividual variability influenced by various factors. For instance, antiplatelet therapy does not curtail the expected effects in a relevant number of patients as demonstrated by the occurrence of repeated cardiovascular events including stent thrombosis and/or by ...
C S, Zuern +3 more
openaire +2 more sources
Strengthening Pharmacogenomics Implementation in Africa: Challenges and Opportunities - A Narrative Review. [PDF]
Health Sci RepABSTRACT Background and Aim The discipline of pharmacogenomics (PGx) studies the influence of genetic diversity on drug response, bringing the potential to personalized treatment and reduction of adverse effects. Although PGx integration into healthcare is progressing at a global scale, its implementation in Africa faces unique challenges and ...
Mukabyiringiro E +6 more
europepmc +2 more sources
Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]
, 2011 Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core +1 more source
Cannabis Pharmacogenomics: A Path to Personalized Medicine
Current Issues in Molecular Biology, 2023 Cannabis and related compounds have created significant research interest as a promising therapy in many disorders. However, the individual therapeutic effects of cannabinoids and the incidence of side effects are still difficult to determine ...
Mariana Babayeva, Zvi G. Loewy
doaj +1 more source