Results 31 to 40 of about 39,211 (299)

Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow

Frontiers in Pharmacology, 2019
Pharmacogenomics has been recognized as a fundamental tool in the era of personalized medicine with up to 266 drug labels, approved by major regulatory bodies, currently containing pharmacogenomics information. Next-generation sequencing analysis assumes
Efstathia Giannopoulou, Theodora Katsila, Christina Mitropoulou, Evangelia-Eirini Tsermpini, George P. Patrinos, George P. Patrinos, George P. Patrinos   +6 more
doaj   +1 more source

Cardiovascular Pharmacogenomics [PDF]

Circulation Research, 2011
Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin ...
Dan M, Roden, Julie A, Johnson, Stephen E, Kimmel, Ronald M, Krauss, Marisa Wong, Medina, Alan, Shuldiner, Russell A, Wilke   +6 more
openaire   +2 more sources

Knowledge, attitude, perception, and self-reported confidence of community pharmacists towards pharmacogenomics services

Journal of Pharmaceutical Policy and Practice
Background Pharmacogenomics is used to optimise patient drug therapy. The role of community pharmacists in the implementation of pharmacogenomics services is emerging. This study evaluated the knowledge, attitude, perception, and self-reported confidence
Usman Abubakar, Lienarrubini Subramaniam, Amer Hayat Khan   +2 more
doaj   +1 more source

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study [PDF]

, 2020
OBJECTIVES: Pharmacogenetic panel-based testing represents a new model for precision medicine. A sufficiently powered prospective study assessing the (cost-)effectiveness of a panel-based pharmacogenomics approach to guide pharmacotherapy is lacking ...
Ubiquitous Pharmacogenomics Consortium, Apotheek Klinische Farmacie   +1 more
core  

Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays

Scientific Reports, 2021
Single-nucleotide polymorphisms (SNPs) are the most common genetic variations for various complex human diseases, including cancers. Genome-wide association studies (GWAS) have identified numerous SNPs that increase cancer risks, such as breast cancer ...
Nurul Ain Khoruddin, Mohd NurFakhruzzaman Noorizhab, Lay Kek Teh, Farida Zuraina Mohd Yusof, Mohd Zaki Salleh   +4 more
doaj   +1 more source

Role of pharmacogenomics in the treatment of tuberculosis: a review [PDF]

, 2012
Geetha Ramachandran, Soumya SwaminathanNational Institute for Research in Tuberculosis, Indian Council of Medical Research, Chennai, IndiaBackground: Tuberculosis is one of the major public health problems worldwide.
Ramachandran G, Swaminathan S, Ramachandran, Geetha, Swaminathan, Soumya   +3 more
core   +1 more source

Construction of a femininity score in the UK Biobank and its association with angina diagnosis prior to myocardial infarction

Scientific Reports, 2022
Gender captures social components beyond biological sex and can add valuable insight to health studies in populations. However, assessment of gender typically relies on questionnaires which may not be available.
Anna Levinsson, Simon de Denus, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Joëlle Rouleau, Jean-Claude Tardif, Julie Hussin, Marie-Pierre Dubé   +7 more
doaj   +1 more source

Pharmacogenomics of oxycodone: a narrative literature review

, 2021
Oxycodone is a semisynthetic μ- and κ-opioid receptor with agonist with a broad scope of use including postoperative analgesia as well as control of neuropathic and cancer pain.
Rossos, Ryan, Umukoro, Nelly N., Aruldhas, Blessed W., Pawale, Dhanashri, Renschler, Janelle S., Sadhasivam, Senthilkumar, Nelly N Umukoro, Dhanashri Pawale, Blessed W Aruldhas, Ryan Rossos, Senthilkumar Sadhasivam, Janelle S Renschler   +11 more
core   +1 more source

African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa [version 1; peer review: 2 approved]

AAS Open Research, 2019
The African Pharmacogenomics Consortium (APC) was formally launched on the 6th September 2018. This white paper outlines its vision, and objectives towards addressing challenges of conducting and applying pharmacogenomics in Africa and identifies ...
Collet Dandara, Collen Masimirembwa, Yosr Z. Haffani, Bernhards Ogutu, Jenniffer Mabuka, Eleni Aklillu, Oluseye Bolaji, H3Africa   +7 more
doaj   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source