Results 31 to 40 of about 38,200 (304)
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling [PDF]
, 2014 Grazia Daniela Femminella,1 Vincenzo Barrese,2,3 Nicola Ferrara,1,4 Giuseppe Rengo4 1Department of Translational Medical Sciences, Federico II University, Naples, Italy; 2Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II
Ferrara, N +11 more
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Deciphering next-generation pharmacogenomics: an information technology perspective [PDF]
Open Biology, 2014 In the post-genomic era, the rapid evolution of high-throughput genotyping technologies and the increased pace of production of genetic research data are continually prompting the development of appropriate informatics tools, systems and databases as we ...
George Potamias +6 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 Background: Pharmacogenomics is crucial for individualized drug therapy and plays an increasingly vital role in precision medicine decision-making.
Xiaoyong Ge +10 more
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Cannabis Pharmacogenomics: A Path to Personalized Medicine
Current Issues in Molecular Biology, 2023 Cannabis and related compounds have created significant research interest as a promising therapy in many disorders. However, the individual therapeutic effects of cannabinoids and the incidence of side effects are still difficult to determine ...
Mariana Babayeva, Zvi G. Loewy
doaj +1 more source
Pharmacogenomics of oxycodone: a narrative literature review
, 2021 Oxycodone is a semisynthetic μ- and κ-opioid receptor with agonist with a broad scope of use including postoperative analgesia as well as control of neuropathic and cancer pain.
Rossos, Ryan +5 more
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Physicians’ pharmacogenomics information needs and seeking behavior: a study with case vignettes
BMC Medical Informatics and Decision Making, 2017 Background Genetic testing, especially in pharmacogenomics, can have a major impact on patient care. However, most physicians do not feel that they have sufficient knowledge to apply pharmacogenomics to patient care. Online information resources can help
Bret S. E. Heale +4 more
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Pharmacogenomics in early-phase clinical development. [PDF]
, 2013 Pharmacogenomics (PGx) offers the promise of utilizing genetic fingerprints to predict individual responses to drugs in terms of safety, efficacy and pharmacokinetics.
Burt, Tal, Dhillon, Savita
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Pharmacogenomics, 2010 Irinotecan is a camptothecin analog used as an anticancer drug. Severe, potentially life-threatening toxicities can occur from irinotecan treatment. Although multiple genes may play a role in irinotecan activity, the majority of evidence to date suggests that variation in expression of UGT1A1 caused by a common promoter polymorphism (UGT1A1*28) is ...
Sharon, Marsh, Janelle M, Hoskins
openaire +3 more sources
Cardiovascular pharmacogenomics
Experimental Physiology, 2005 There is large interpatient variability in the response to drugs, including cardiovascular drugs. Thus, while some patients achieve the desired therapeutic response from their drug therapy, others do not. There is also a subset of patients who will experience adverse effects, which can range from bothersome to life threatening. Research in recent years
Julie A, Johnson, Larisa H, Cavallari
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Seminars in Perinatology, 2020 Pregnant women frequently take prescription and over the counter medications. The efficacy of medications is affected by the many physiological changes during pregnancy, and these events may be further impacted by genetic factors. Research on pharmacogenomic and pharmacokinetic influences on drug disposition during pregnancy has lagged behind other ...
Hannah K, Betcher, Alfred L, George
openaire +3 more sources