Results 31 to 40 of about 34,942 (245)

Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays

Scientific Reports, 2021
Single-nucleotide polymorphisms (SNPs) are the most common genetic variations for various complex human diseases, including cancers. Genome-wide association studies (GWAS) have identified numerous SNPs that increase cancer risks, such as breast cancer ...
Nurul Ain Khoruddin, Mohd NurFakhruzzaman Noorizhab, Lay Kek Teh, Farida Zuraina Mohd Yusof, Mohd Zaki Salleh   +4 more
doaj   +1 more source

African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa [version 1; peer review: 2 approved]

AAS Open Research, 2019
The African Pharmacogenomics Consortium (APC) was formally launched on the 6th September 2018. This white paper outlines its vision, and objectives towards addressing challenges of conducting and applying pharmacogenomics in Africa and identifies ...
Collet Dandara, Collen Masimirembwa, Yosr Z. Haffani, Bernhards Ogutu, Jenniffer Mabuka, Eleni Aklillu, Oluseye Bolaji, H3Africa   +7 more
doaj   +1 more source

Construction of a femininity score in the UK Biobank and its association with angina diagnosis prior to myocardial infarction

Scientific Reports, 2022
Gender captures social components beyond biological sex and can add valuable insight to health studies in populations. However, assessment of gender typically relies on questionnaires which may not be available.
Anna Levinsson, Simon de Denus, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Joëlle Rouleau, Jean-Claude Tardif, Julie Hussin, Marie-Pierre Dubé   +7 more
doaj   +1 more source

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC) [PDF]

, 2018
The P2Y12 receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke.
International Clopidogrel Pharmacogenomics Consortium
core   +1 more source

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX

BMC Biology, 2018
Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis, Rosette Lidereau, François Lallemand, Keltouma Driouch   +18 more
doaj   +1 more source

Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases

Cancer Cell International, 2023
Background Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases (mCLM) and matched non-malignant ...
Lucie Heczko, Viktor Hlaváč, Petr Holý, Pavel Dvořák, Václav Liška, Ondřej Vyčítal, Ondřej Fiala, Pavel Souček   +7 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Role of pharmacogenomics in the treatment of tuberculosis: a review [PDF]

, 2012
Geetha Ramachandran, Soumya SwaminathanNational Institute for Research in Tuberculosis, Indian Council of Medical Research, Chennai, IndiaBackground: Tuberculosis is one of the major public health problems worldwide.
Ramachandran G, Swaminathan S, Ramachandran, Geetha, Swaminathan, Soumya   +3 more
core   +1 more source

Empowering precision medicine: Insights from a national survey on pharmacogenomics knowledge, attitudes, and perceptions among community pharmacists in the UAE

Exploratory Research in Clinical and Social Pharmacy
Background: Community pharmacists are essential to pharmacogenomics implementation because they can help trainers, clinical advisors, and other medical professionals understand the importance of pharmacogenomics and encourage them to use it in their ...
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Mena Al-Ani, Mustafa Aal Yaseen, Mahmood H. Al-Aawad, Ghala Rashid Alnuaimi, B. Mahalakshmi   +7 more
doaj   +1 more source

Clinical practice guidelines for translating pharmacogenomic knowledge to bedside. Focus on anticancer drugs.

Frontiers in Pharmacology, 2014
The development of clinical practice recommendations or guidelines for the clinical use of pharmacogenomics data is an essential issue for improving drug therapy, particularly for drugs with high toxicity and/or narrow therapeutic index such as ...
José A G Agúndez, José A G Agúndez, Gara eEsguevillas, Gara eEsguevillas, Gemma eAmo, Gemma eAmo, Elena eGarcía-Martín, Elena eGarcía-Martín   +7 more
doaj   +1 more source