Results 51 to 60 of about 67,526 (234)

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

The needs and gaps in pharmacogenomics knowledge and education among healthcare professionals in Malaysia: A multisite Delphi study

Clinical and Translational Science
Lack of pharmacogenomics knowledge among healthcare professionals is the most significant cited barrier to implementing pharmacogenomics in clinical settings.
Safa Omran, Siew Lian Leong, Ali Blebil, Devi Mohan, Wei Chern Ang, Siew Li Teoh   +5 more
doaj   +1 more source

Knowledge, Perception, and Application of Pharmacogenomics Among Hospital Pharmacists in Saudi Arabia

Risk Management and Healthcare Policy, 2020
Mohammed Algahtani Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi ArabiaCorrespondence: Mohammed Algahtani Email msalqahtane@nu.edu.saIntroduction: The accelerated transformation in the healthcare system ...
Algahtani M
doaj  

Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision‐Making and Polygenic Embryo Screening

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome‐wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions.
Lauren A. Ginn, Amanda R. Merner, Page M. Trotter, Kaitlynn P. Craig, Abigail C. Martinez, Ana Lucía Battaglino, Dorit Barlevy, Daphne M. Ayton, Takahiro Soda, Eric A. Storch, Gabriel Lázaro‐Muñoz, Stacey Pereira   +11 more
wiley   +1 more source

Implementing health economics for pharmacogenomics research translation in Africa

Communications Medicine
Pharmacogenomics studies how a person’s inherited genes influence response to therapeutic drugs. Many drugs do not work in all patients and pharmacogenomics can assist in the identification of patients who are better suited to particular drugs or ...
Mohamed Zahir Alimohamed, George Dennis Obeng, Marcell Csanadi, Collen Masimirembwa, Collet Dandara   +4 more
doaj   +1 more source

ANK1 and EPB41 Variants and The Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, Accepted Article.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Pharmacogenomics and Opioid Analgesics: Clinical Implications

International Journal of Genomics, 2015
Variation exists in patient response on analgesic treatment in terms of efficacy and safety. This variation may be in part explained by pharmacogenomics.
Eugenia Yiannakopoulou
doaj   +1 more source

Molecular Functions of WWOX Potentially Involved in Cancer Development

Cells, 2021
The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated
Karim Taouis, Keltouma Driouch, Rosette Lidereau, François Lallemand   +3 more
doaj   +1 more source

Relevance of pharmacogenomics for developing countries in Europe : implementation in the Maltese population [PDF]

, 2012
Pharmacogenomics is a promising new discipline that can realize personalized treatment for patients suffering from many common diseases, particularly those with multiple treatment modalities.
Borg, Joseph J., Fenech, Anthony G., Grech, Godfrey, Mitropoulos, Konstantinos, Mitropoulou, Christina, Patrinos, George P., Vozikis, Athanassios   +6 more
core  

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine [PDF]

, 2019
Here we describe a collaboration between industry, the National Health Service (NHS) and academia that sought to demonstrate how early understanding of both pharmacology and genomics can improve strategies for the development of precision medicines ...
A Cilli, AA Agyeman, AE Tilley, AL Chokas, AV Biankin, C-H Chou, Carolyn Low, Colin N. A. Palmer, D Cook, David C. Bunton, David Mallinson, E Arif, Elaine M. Gourlay, Erika Cecchin, G Faura Tellez, Graeme Macluskie, H Yang, Hannah Child, J Milara, J-R Yu, Jane Hair, K Linhart, Karen Cowan, Linda Cheyne, M Zanoni, Marian McNeil, Max Bylesjo, ME Ezzie, Michael Finch, MR Trusheim, NJ Schork, PA André, Pamela Brankin, RC Gentleman, S Purcell, Sarah Lynagh, SI Rennard, SJ Mandrekar, SM Paul, T Yang, W Asghar, WE Johnson, Y Chen   +42 more
core   +2 more sources