Results 131 to 140 of about 362,059 (246)

LC-MS/MS Determination of Crotonoside in Rat Plasma and Application to Pharmacokinetic Study. [PDF]

Biomed Chromatogr
Zhang H, Rong D, Qi Q, Liu R, Wang X, Zhang B, Xu W, Yu M, Sy SKB, Wu X.   +9 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Determination of Hecogenin in Mouse Blood by UPLC-MS/MS and Applied to a Pharmacokinetic Study. [PDF]

Biomed Chromatogr
Hu Y, Zhu L, Xiang X, Zou T, Wen C, Duan Q.   +5 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Characterising the pharmacokinetics of olanzapine in patients with anorexia nervosa (TORPEDO): protocol for a multicentre cross-sectional study. [PDF]

BMJ Open
Liang J, Dierckx B, Dieleman GC, Bosch TM, Koch BCP, De Winter BCM.   +5 more
europepmc   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

WCN24-748 ASSESSMENT OF THE EFFECT OF HEPATIC IMPAIRMENT ON IPTACOPAN PHARMACOKINETICS

Kidney International Reports
Robert Schmouder, Kenneth Kulmatycki, Elise Burmeister Getz, Wendy Weiss, Bharti Shah   +4 more
doaj   +1 more source

Scalable Biosynthetic Production of Knotted Peptides Enables ADME and Thermodynamic Folding Studies

ACS Omega, 2021
Christopher J. Schwalen, Charles Babu, Swastik Phulera, Qin Hao, Daniel Wall, David O. Nettleton, Tejas P. Pathak, Piro Siuti   +7 more
doaj   +1 more source

Morphine versus hydromorphone pharmacokinetic <i>vs</i>. pharmacodynamic variabilities. [PDF]

Ann Transl Med
Meissner K, Olofsen E, Dahan A, Kharasch ED.   +3 more
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source