Results 31 to 40 of about 362,059 (246)

Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis

Frontiers in Oncology, 2023
IntroductionAlterations in expression and activity of human receptor tyrosine kinases (RTKs) are associated with cancer progression and in response to therapeutic intervention.MethodsThus, protein abundance of 21 RTKs was assessed in 15 healthy and 18 ...
Areti-Maria Vasilogianni, Zubida M. Al-Majdoub, Brahim Achour, Brahim Achour, Sheila Annie Peters, Sheila Annie Peters, Amin Rostami-Hodjegan, Amin Rostami-Hodjegan, Jill Barber   +8 more
doaj   +1 more source

Immunogenicity assessment strategy for a chemically modified therapeutic protein in clinical development

Frontiers in Immunology
The clinical immunogenicity assessment for complex multidomain biological drugs is challenging due to multiple factors that must be taken into consideration.
Charlotte Hagman, Gaetan Chasseigne, Robert Nelson, Florian Anlauff, Mark Kagan, Allison B. Goldfine, Grzegorz Terszowski, Maria Jadhav   +7 more
doaj   +1 more source

Building in-house PBPK modelling tools for oral drug administration from literature information

ADMET and DMPK, 2019
The interest in using physiologically-based pharmacokinetic (PBPK) models as a support to the drug development decision making process has rapidly increased in the last years. These kind of models are examples of the “bottom up” modelling strategy, which
Silvia Grandoni, Nicola Cesari, Giandomenico Brogin, Paola Puccini, Paolo Magni   +4 more
doaj   +1 more source

Association of HLA-B*5701 Genotypes and Abacavir-Induced Hypersensitivity Reaction: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2015
OBJECTIVES: This study aimed to systematically review and quantitatively synthesize the association between HLA-B*5701 and abacavir-induced hypersensitivity reaction (ABC-HSR).
Wimonchat Tangamornsuksan, Ornrat Lohitnavy, Chuenjid Kongkaew, Nathorn Chaiyakunapruk, Brad Reisfeld, Norman Charles Scholfield, Manupat Lohitnavy   +6 more
doaj   +1 more source

QSAR-based physiologically based pharmacokinetic (PBPK) modeling for 34 fentanyl analogs: model validation, human pharmacokinetic prediction and abuse risk insights

Frontiers in Pharmacology
IntroductionFentanyl analogs, as emerging new psychoactive substances (NPS), pose a global public health threat due to widespread abuse, high toxicity, and frequent overdose fatalities.
Simeng Zhang, Simeng Zhang, Yawen Xu, Yawen Xu, Xianbin Zeng, Jingzhi Ran, Jingzhi Ran, Yuanyuan Chen, Yuanyuan Chen, Lixin Kuai, Lixin Kuai, Kaixi Li, Kaixi Li, Peng Xu, Peng Xu, Peng Xu, Fang Yan, Fang Yan, Dan Wang, Dan Wang   +19 more
doaj   +1 more source

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling

Pharmaceutics, 2023
The most common method for establishing bioequivalence (BE) is to demonstrate similarity of concentration–time profiles in the systemic circulation, as a surrogate to the site of action.
Chunyan Han, Tiancheng Sun, Siri Kalyan Chirumamilla, Frederic Y. Bois, Mandy Xu, Amin Rostami-Hodjegan   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nucleic Acid Delivery by Solid Lipid Nanoparticles Containing Switchable Lipids: Plasmid DNA vs. Messenger RNA

Molecules, 2020
The development of safe and effective nucleic acid delivery systems remains a challenge, with solid lipid nanoparticle (SLN)-based vectors as one of the most studied systems.
Itziar Gómez-Aguado, Julen Rodríguez-Castejón, Mónica Vicente-Pascual, Alicia Rodríguez-Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís Aspiazu   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Tissue cages in calves for studies on pharmacokinetic/pharmacodynamic relationships of antimicrobials [PDF]

, 2003
Knowledge on pharmacokinetic/pharmacodynamic (PK/PD) relationships of antimicrobials may assist in defining a dose that maximises effect while minimising side effects such as selection of resistance.
Greko, Christina
core   +1 more source