Results 131 to 140 of about 361,016 (249)

Comment on "Phase I Randomized, Placebo-Controlled, Cross-Over Dose-Finding Study of Coenzyme Q₁₀ on Doxorubicin Pharmacokinetics During Breast Cancer Treatment". [PDF]

Integr Cancer Ther
Lei Z.
europepmc   +1 more source

#182 : Pharmacokinetics of Ovarian Stimulation for Projected Poor Responder Patients in IVF. A Randomised Trial Comparing a Corifollitropin Alfa Agonist Flare Protocol with a Corifollitropin Alfa Antagonist Protocol

, 2023
Kaushalya Arulpragasam, Mary Elizabeth O’Neil, Prudence Sweeten, Devora Lieberman, Rachael J. Rodgers, Shannon Choi, Joan Tan, Nancy Briggs, William J. Ledger   +8 more
openalex   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, EarlyView.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source

Pharmacokinetics of ceftriaxone in patients with typhoid fever

, 1994
Gopal P. Acharya, C Crevoisier, Thomas Butler, M Ho, Manjari Tiwari, K. Stoeckel, Charles Bradley   +6 more
openalex   +2 more sources

Population pharmacokinetic analysis of OT-101 (trabedersen) in patients with advanced tumors [PDF]

, 2017
W. Wang, Kenneth Ng, Dong Ho Nam, V. Trieu, Lindsay Hwang   +4 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Correction to: An automated pipeline to generate initial estimates for population Pharmacokinetic base models. [PDF]

J Pharmacokinet Pharmacodyn
Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF.   +5 more
europepmc   +1 more source

Pharmacokinetics of Uridine Following Ocular, Oral and Intravenous Administration in Rabbits

, 2013
Eun Young Kim, Wonku Kang
openalex   +2 more sources

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Comparative pharmacokinetics of voriconazole between elderly and young adult patients: a population pharmacokinetic study. [PDF]

J Pharm Policy Pract
Zaryab Zakria K, Usman M, Bilal H, Akbar Z, Hussain T, Ali M, Sattar A, Alvi I, Rasheed H, Zulfiqar S, Rehan Khan M, Zahid Mushtaq M.   +11 more
europepmc   +1 more source