Results 141 to 150 of about 361,016 (249)

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Pharmacokinetic study of Q808 in rhesus monkey using liquid chromatography–tandem mass spectrometry [PDF]

Ning Xiao, Xiang Li, Wei Li, Jialin Zhao, Yingnan Li, Limei Wang   +5 more
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Correction: Population Pharmacokinetics Analysis of Infliximab in up to 10‑Year‑Old Patients with Paediatric Inflammatory Bowel Disease: Label‑Recommended Dose Fails to Achieve Therapeutic Target Concentration. [PDF]

Clin Pharmacokinet
Zhao Q, Jongsma MME, Vuijk SA, de Winter BCM, Martinez-Vinson C, Kolho KL, Norsa L, Hussey S, Wine E, Cohen S, Shouval DS, Assa A, Lev-Tzion R, de Meij T, Wolters VM, Huynh HQ, Preijers T, de Ridder L.   +17 more
europepmc   +1 more source

Diagnostic Study of a Synthetic Human Corticotropin-Releasing Hormone (hCRH) in Healthy Adult Males: Its Plasma Pharmacokinetics and the Effects on the Urinary Excretion of Steroid Hormones.

, 1993
KOSHI TANAKA, MECUMI NAGATA, Sachiko Itoh, Munehito Kumagae, N Shimizu   +4 more
openalex   +2 more sources

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Correction: How is Levetiracetam Monotherapy Currently Monitored in Pregnancy? A Systematic Review. [PDF]

Clin Pharmacokinet
Rademaker T, Goo Y, Soh MC, Pasupathy D, Wong C, Bleasel A, Alffenaar JW.   +6 more
europepmc   +1 more source

Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype [PDF]

, 2009
Ina M. Scholz, Heike Oberwittler, Klaus‐Dieter Riedel, Jürgen Burhenne, Johanna Weiß, Walter E. Haefeli, Gerd Mikus   +6 more
openalex   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Comparative Pharmacokinetics and Insulin Action for Three Rapid-Acting Insulin Analogs Injected Subcutaneously With and Without Hyaluronidase [PDF]

, 2012
Linda Morrow, Douglas B. Muchmore, Marcus Hompesch, Elizabeth Ludington, Daniel E. Vaughn   +4 more
openalex   +1 more source