Results 261 to 270 of about 905,269 (391)

Pharmacokinetics of cyclophosphamide in man [PDF]

, 1971
Joseph L. Cohen, John Y. Jao, William J. Jusko   +2 more
openalex   +1 more source

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source

Pharmacokinetics, efficacy and safety of palbociclib and fulvestrant in a patient with hormone receptor-positive, human epidermal growth factor receptor 2 negative metastatic breast cancer with end-stage renal disease undergoing hemodialysis: A case report. [PDF]

Invest New Drugs
Takakura T, Iwasa T, Imamura CK, Watanabe S, Hayashi H.   +4 more
europepmc   +1 more source

Cefamandole: In Vitro and Clinical Pharmacokinetics

, 1976
R. S. Griffith, Henry R. Black, Gordon Brier, J. D. Wolny   +3 more
openalex   +1 more source

Analgesic Action and Pharmacokinetics of Morphine and Diazepam in Man [PDF]

, 1979
Jian Yang, W. Crawford Clark, S. H. Ngai, Barry A. Berkowitz, Sydney Spector   +4 more
openalex   +1 more source

Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination Strategy

Advanced Science, EarlyView.
A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu, Liting Huang, Suzhen Bi, WeiKaixin Kong, Wanting Feng, Yingjia Li, Zhengwei Xie, Peipei Shan, Sujie Zhu   +8 more
wiley   +1 more source

The Impact of Genetic Polymorphisms on the Clinical Efficacy of Azole Antifungals. [PDF]

Genes (Basel)
Singam H, Mossad S.
europepmc   +1 more source

Pharmacokinetics of intravenous piperacillin in patients undergoing chronic hemodialysis [PDF]

, 1979
Elliot Francke, Gerald B. Appel, Harold C. Neu   +2 more
openalex   +1 more source

Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones

Clinical Pharmacokinetics, 2018
C. Roger, J. Roberts, L. Muller
semanticscholar   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source