Results 271 to 280 of about 599,269 (342)

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

Convertible ROS Nanocatalyst/Eliminator for Enhancing Tumor Radio‐Immunotherapy and Relieving Radiation Enteritis

Advanced Science, EarlyView.
A novel Janus Ag/Ag2S nanostructure grafted with dimer PD‐L1 affibody (AMZ) is successfully developed. AMZ can be used as ROS nanocatalyst to achieve tumor radiosensitization, and it can also act as an ROS eliminator to alleviate radiation enteritis, achieving a radiotherapy strategy characterized by “toxicity reduction and efficacy enhancement ...
Mengmeng Zhang, Xinyu Zhang, Chenyu Wang, Mengyao Mu, Ke Ren, Nengyi Ni, Li Xian Yip, Kai Guo, Xiaoyu Hu, Feifei Teng, David Tai Leong, Qing Fan, Xiao Sun   +12 more
wiley   +1 more source

Allopregnanolone Concentrations After Ascending Single Dose Administration of Progesterone to Healthy Volunteers. [PDF]

Hum Psychopharmacol
Hughes-Medlicott NJ, Nguyen H, Glue P, Barak Y.   +3 more
europepmc   +1 more source

Pharmacokinetics of FK 506 in transplant patients [PDF]

, 1991
Abu-Elmagd, K, Alessiani, M, Flowers, J, Fung, J, Jain, A, Krajak, A, Lever, J, Mehta, S, Starzl, TE, Todo, S, Venkataramanan, R, Warty, VS, Zuckerman, S   +12 more
core  

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

Effect of CYP2D6 and ABCB1 polymorphisms on pharmacokinetics and efficacy of aripiprazole in pediatric tic disorders. [PDF]

BMC Pediatr
Xin Y, Gao L, Li S, Wang J, Chen C, Tuo Y, Nie G, Li R, Sun D, Fu Y, Wang Y, Liu Z.   +11 more
europepmc   +1 more source

PHARMACOKINETICS OF THIOPENTONE: EFFECTS OF ENFLURANE AND NITROUS OXIDE ANAESTHESIA AND SURGERY

, 1978
Mohammed M. Ghoneim, Michael J. Van Hamme   +1 more
openalex   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source