Results 41 to 50 of about 628,142 (342)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

CPT: Pharmacometrics & Systems Pharmacology, 2022
As one of the key components in model‐informed drug discovery and development, physiologically‐based pharmacokinetic (PBPK) modeling linked with in vitro‐to‐in vivo extrapolation (IVIVE) is widely applied to quantitatively predict drug–drug interactions (
Shinji Yamazaki, Raymond Evers, Loeckie De Zwart   +2 more
doaj   +1 more source

Cyclosporine Absorption Following Orthotopic Liver Transplantation [PDF]

, 1986
Blood concentrations of cyclosporine were determined in adult and pediatric patients following orthotopic liver transplantation to quantitate cyclosporine blood clearance and oral absorption.
Beveridge, Burckart, Burckart, Calne, Calne, Holt, Kahan, Kennedy, Malatack, Miles, Ptachcinski, Ptachcinski, Ptachcinski, Sawchuk, Starzl, Starzl, Starzl, Venkataramanan, Venkataramanan, Venkataramanan, Wood   +20 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Formononetin–piperine–phospholipid complex: enhancement of anti-osteoporotic activity and bioavailability in bone marrow in rats

Future Journal of Pharmaceutical Sciences
Background Formononetin (FNT), a phytoestrogen, has shown osteogenic effects in ovariectomy-induced osteoporosis, but its therapeutic use is limited by poor bioavailability.
Arun Agarwal, Shailesh D. Dadge, Richa Garg, Divya Chauhan, Roshan Katekar, Debalina Maity, Sachin K. Vishwakarma, Shivam Rathaur, Shubhi Yadav, Jiaur R. Gayen   +9 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine:pharmacokinetic and dosage-related findings from a clinical trial in Uganda [PDF]

, 2006
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack ...
Babigumira, Joseph, Bajunirwe, Francis, Biraro, Samuel, Checchi, Francesco, Ferradini, Laurent, Fogg, Carole, Grandesso, Francesco, Guthmann, Jean-Paul, Kigozi, Isaac, Kiguli, James, Kyomuhendo, Juliet, Piola, Patrice, Ruzagira, Eugene, Taylor, Walter R. J.   +13 more
core   +3 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Bioequivalence trials for the approval of generic drugs in Saudi Arabia: a descriptive analysis of design aspects

BMC Medical Research Methodology
Background This retrospective analysis aimed to comprehensively review the design and regulatory aspects of bioequivalence trials submitted to the Saudi Food and Drug Authority (SFDA) since 2017.
Turki A. Althunian, Bader R. Alzenaidy, Raseel A. Alroba, Ohoud A. Almadani, Fahad A. Alqahtani, Albatool A. Binajlan, Amal I. Almousa, Deema K. Alamr, Malak S. Al-Mofada, Nora Y. Alsaqer, Hessa A. Alarfaj, Abdulmohsen A. Bahlewa, Mohammed A. Alharbi, Ali M. Alhomaidan, Abdulaziz A. Alsuwyeh, Abdulmohsen A. Alsaleh   +15 more
doaj   +1 more source

Delayed hepatic uptake of multi-phosphonic acid poly(ethylene glycol) coated iron oxide measured by real-time Magnetic Resonance Imaging

, 2016
We report on the synthesis, characterization, stability and pharmacokinetics of novel iron based contrast agents for magnetic resonance imaging (MRI). Statistical copolymers combining multiple phosphonic acid groups and poly(ethylene glycol) (PEG) were ...
Berret, J. -F., Doan, B. -T., Graillot, A., Loubat, C., Mignet, N., Ramniceanu, G., Vezignol, C.   +6 more
core   +3 more sources