Results 41 to 50 of about 865,562 (415)

Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection

Journal of Pharmaceutical Health Care and Sciences, 2023
Background Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species.
Daisuke Negishi, Okimichi Mitsumatsu, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu, Hiroshi Yamazaki   +5 more
doaj   +1 more source

A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

Pharmaceutics, 2021
Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang, Zexin Zhang, Ping Li, Weimin Kong, Xiaodong Liu, Li Liu   +5 more
doaj   +1 more source

The Pharmacokinetics of Vitamin C

Nutrients, 2019
The pharmacokinetics of vitamin C (vitC) is indeed complex. Regulated primarily by a family of saturable sodium dependent vitC transporters (SVCTs), the absorption and elimination are highly dose-dependent. Moreover, the tissue specific expression levels
J. Lykkesfeldt, P. Tveden-Nyborg
semanticscholar   +1 more source

Pharmacokinetics of Monoclonal Antibodies

CPT: Pharmacometrics & Systems Pharmacology, 2017
Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of pharmacotherapeutic interventions in a variety of indications, with currently more than 40 mAbs approved by the US Food and Drug Administration, and several dozens ...
J. Ryman, B. Meibohm
semanticscholar   +1 more source

Pharmacokinetics for the prescriber

Medicine, 2003
Pharmacokinetics is the science that describes (using the ADME approach) the absorption of a drug from its site of administration, its distribution throughout the body, its metabolism or conjugation, and its excretion from the body. Pharmacokinetics can be thought of as what the body does to the drug.
Howard L. McLeod, Yijing He
openaire   +2 more sources

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Phytotherapy Research, 2016
Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum.
Xiaoxv Dong, Jing Fu, Xingbin Yin, Sali Cao, Xuechun Li, Longfei Lin, Jian Ni   +6 more
semanticscholar   +1 more source

An Investigation on Glucuronidation Metabolite Identification, Isozyme Contribution, and Species Differences of GL-V9 In Vitro and In Vivo

Molecules, 2019
GL-V9 is a prominent derivative of wogonin with a wide therapeutic spectrum and potent anti-tumor activity. The metabolism characteristics of GL-V9 remain unclear.
Han Xing, Dexuan Kong, Chen Ning, Ying Kong, Chang Ren, Yujie Cheng, Hui Cai, Jubo Wang, Di Zhao, Ning Li, Xijing Chen, Zhiyu Li, Yang Lu   +12 more
doaj   +1 more source

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors

Clinical Pharmacokinetics, 2019
Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical impact in improving overall survival of several malignancies associated with poor outcomes; however, only 20–40% of patients will show long-lasting survival. Further clarification
M. Centanni, D. Moes, I. Trocóniz, J. Ciccolini, J. G. V. van Hasselt   +4 more
semanticscholar   +1 more source

Metabolism of ticagrelor in patients with acute coronary syndromes. [PDF]

, 2018
© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its ...
B Ibanez, C Varenhorst, D Alexopoulos, D Aradi, D Lindholm, D Zhou, EA Amsterdam, F Franchi, G Parodi, G Parodi, H Sillén, HS Smith, J Kubica, J Kubica, J Li, JH Cornel, JM Siller-Matula, K Butler, K Butler, K Thygesen, M Koziński, M Roffi, P Adamski, P Adamski, P Adamski, P Adamski, P Niezgoda, P Niezgoda, PG Steg, PG Steg, PT O’Gara, R Teng, R Teng, R Teng, R Teng, R Teng, R Teng, RA Lange, S Husted, S James, SE Husted, SS Brar   +41 more
core   +1 more source

A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114

CPT: Pharmacometrics & Systems Pharmacology, 2022
TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine.
Hikari Araki, Toru Takenaka, Koichi Takahashi, Fumiaki Yamashita, Kazuaki Matsuoka, Kunihiro Yoshisue, Ichiro Ieiri   +6 more
doaj   +1 more source