Results 41 to 50 of about 219,082 (266)

Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-group Prospective Cohort Study in two sub-Saharan Africa Populations. [PDF]

, 2013
We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209)
A Habtewold, A Kassu, A Tsegaye, Abiy Habtewold, AS Belanger, BA Ward, BR Schackman, C Nyakutira, D Burger, DY Cho, E Aklillu, E Gebeyehu, E Ngaimisi, E Saathoff, Eleni Aklillu, Eliford Ngaimisi, ES Lugada, Eyasu Makonnen, F Prugnolle, Ferdinand Mugusi, G Yimer, G Yimer, Getachew Aderaye, Getnet Yimer, J Burhenne, J di Iulio, JK Mukonzo, JK Mukonzo, Juergen Burhenne, Klaus-Dieter Riedel, L Elens, Leif Bertilsson, LF Lopez-Cortes, M Maimbo, M Swart, Mohammed Janabi, Omary Minzi, S Hodder, S Mugusi, Sabina Mugusi, Sean Emery, SF Mugusi, SG Heil, SR Faucette, SR Faucette, V Gounden, W Stohr, Wondwossen Amogne, Y Jamshidi   +48 more
core   +2 more sources

Nanomaterials and pharmacokinetics

, 2021
Nanomaterials have outstanding applications in biomedical areas, such as drug delivery agents, nanoparticles-based imaging, magnetic fluid hyperthermia, and tissue regeneration. In the line of extensive development in nanomaterials-aided drug delivery platforms, pharmacokinetic assessments have achieved greater consideration from scientists and ...
Somvanshi, Sandeep B., Kharat, Prashant B., Jadhav, K.M., Thorat, Nanasaheb D., Townley, Helen   +4 more
openaire   +1 more source

Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug

CPT: Pharmacometrics & Systems Pharmacology, 2023
In celiac disease (CeD), gastrointestinal CYP3A4 abundance and morphology is affected by the severity of disease. Therefore, exposure to CYP3A4 substrates and extent of drug interactions is altered.
Farzaneh Salem, Ali Nimavardi, Jennypher Mudunuru, Debra Tompson, Jackie Bloomer, David B. Turner, Kunal S. Taskar   +6 more
doaj   +1 more source

Population pharmacokinetics of levobupivacaine during a transversus abdominis plane block in children [PDF]

Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2019, pp.1, 2019
BACKGROUND:Levobupivacaine is commonly used during transversus abdominis plane block in pediatric patients. However, the dosing regimen is still empirical, and the pharmacokinetic properties of levobupivacaine are not considered. Here, the pharmacokinetics of levobupivacaine during an ultrasound-guided transversus abdominis plane block were evaluated ...
arxiv   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children [PDF]

, 2015
The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillintazobactam in children hospitalized in an intensive care unit.
Buenger, Lauren E., Chung, Eun Kyoung, Crumby, Ashley S., Dees, Jennifer, Healy, Daniel P., Kays, Michael B., Knoderer, Chad A., Nichols, Kristen R.   +7 more
core   +2 more sources

Time Scale Calculus: A New Approach to Multi-Dose Pharmacokinetic Modeling [PDF]

arXiv, 2023
In this paper, we use Time Scale Calculus (TSC) to formulate and solve pharmacokinetic models exploring multiple dose dynamics. TSC is a mathematical framework that allows the modeling of dynamical systems comprising continuous and discrete processes.
arxiv  

A series acceleration algorithm for the gamma-Pareto (type I) convolution and related functions of interest for pharmacokinetics [PDF]

, 2021
The gamma-Pareto type I convolution (GPC type I) distribution, which has a power function tail, was recently shown to describe the disposition kinetics of metformin in dogs precisely and better than sums of exponentials. However, this had very long run times and lost precision for its functional values at long times following intravenous injection.
arxiv   +1 more source

Physiologically‐Based Pharmacokinetic Modeling Approach to Predict Rifampin‐Mediated Intestinal P‐Glycoprotein Induction

CPT: Pharmacometrics & Systems Pharmacology, 2019
Physiologically‐based pharmacokinetic (PBPK) modeling is a powerful tool to quantitatively describe drug disposition profiles in vivo, thereby providing an alternative to predict drug–drug interactions (DDIs) that have not been tested clinically.
Shinji Yamazaki, Chester Costales, Sarah Lazzaro, Soraya Eatemadpour, Emi Kimoto, Manthena V. Varma   +5 more
doaj   +1 more source

Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital

Journal of Pharmaceutical Health Care and Sciences, 2021
Background Although the over-the-counter H1 receptor antagonist diphenhydramine is not a common drug of abuse, it was recently recognized as one of the substances causing acute poisoning in patients attempting suicide that led to admissions to our ...
Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu, Hiroshi Yamazaki   +5 more
doaj   +1 more source

An Integrated Transfer Learning and Multitask Learning Approach for Pharmacokinetic Parameter Prediction [PDF]

, 2018
Background: Pharmacokinetic evaluation is one of the key processes in drug discovery and development. However, current absorption, distribution, metabolism, excretion prediction models still have limited accuracy. Aim: This study aims to construct an integrated transfer learning and multitask learning approach for developing quantitative structure ...
arxiv   +1 more source