Results 111 to 120 of about 5,164,203 (303)

A Review on Pharmacological Activities of Calotropis Procera [PDF]

, 2019
The plant Calotropis procera  (Aiton) Dryand belong to the Apocynaceae family it is popularly known as “Rui” in Marathi, “ Mudar” in hindi other common name include Rubber Bush, Apple of sodom. (India & Pakistan).
Mali, Rohit P, Jadhav, R. S., Rao, Priya S   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Article Review: Pharmacological Activities of Renggak Plant (Amomum dealbatum Roxb.) [PDF]

The renggak plant (Amomum dealbatum Roxb.) is a native plant of Lombok Island that belongs to the Zingiberaceae family and is traditionally used as a remedy for coughs, diarrhea, arthritis, and eye washes.
Cahyani, Dina Fathia, Hidayati, Agriana Rosmalina   +1 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The molecular effects underlying the pharmacological activities of daphnetin [PDF]

As an increasingly well-known derivative of coumarin, daphnetin (7,8-dithydroxycoumarin) has demonstrated various pharmacological activities, including anti-inflammation, anti-cancer, anti-autoimmune diseases, antibacterial, organ protection, and ...
Sujun Gao, Zhifeng Wei, Long Su, Na Wei
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chemical Constituents and Biological Activities of Cassia Genus: Review

Archives of Pharmaceutical Sciences Ain Shams University, 2019
A review of chemical constituents and pharmacological activities of genus Cassia, Family Leguminosae has been presented. There are about 600 species of this genus distributed all around the world. Many of these species are still not investigated.
Safaa Hafez, Samir Othman, Haitham Ibrahim   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pharmacological Activities of Mogrosides [PDF]

Future Medicinal Chemistry, 2018
Can, Liu, Longhai, Dai, Yueping, Liu, Dequan, Dou, Yuanxia, Sun, Lanqing, Ma   +5 more
openaire   +2 more sources

Research Progress in the Treatment of Vaginitis With Bioactive Compounds: Targeting of Vaginal Microflora

MicrobiologyOpen
Vaginitis, a common gynecological ailment among women, poses a considerable health challenge with high recurrence rates even after conventional treatment.
Yongming Li, Huiyu Liu, Ruihan Li, Rong Li, Jiaqi Liu   +4 more
doaj   +1 more source