Results 91 to 100 of about 5,164,203 (303)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

The Pharmacological Activities of Glycyrrhizinic Acid (“Glycyrrhizin”) and Glycyrrhetinic Acid

, 2018
Glycyrrhizin or, more correctly, Glycyrrhizinic acid is a triterpenoid saponin obtained from the root and rhizome extracts of Licorice (Glycyrrhiza glabra), being commonly used as a sweetener, being reported as – at least – 30 times sweeter than sucrose.
Graebin, Cedric Stephan; id_orcid, Cedric Stephan Graebin   +1 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Pharmacological activities on Ephedra nebrodensis Tineo

, 2010
As a part of our endeavour to screen Mediterranean medicinal plants for various pharmacological activities, we evaluated antihistaminic, adaptogenic, anti-inflammatory, antinociceptive, hypotensive and locomotor properties, and antioxidant potential of
Kasture S., Scartezzini P, Petitto V, Foddis C, SANNA, CINZIA, Poli F, Longoni R, Spina L, BALLERO, MAURO, Serafini M, Stanzione A, Serilli AM, Bianco A   +12 more
core   +2 more sources

Phytochemical ingredients and Pharmacological potential of Calendula officinalis Linn.

Pharmaceutical and Biomedical Research, 2018
Calendula officinalis Linn. commonly known as marigold has long history of usage by the folklore system. It has a high economic value as herbal medicine and is widely used in cosmetics, perfumes, dyes, pharmaceutical preparations and food products for ...
Pawan Kumar Verma, Rajinder Raina, Sanjay Agarwal, Harpreet Kaur   +3 more
doaj  

Ethnopharmacology, phytochemistry, bioactivities and quality control of the Gnaphalium genus: an updated review

Medicinal Plant Biology
The genus Gnaphalium (Asteraceae) is distributed across most regions of the world. Some of them are not only used as a food source, but has also been used for the treatment of various diseases including pain, rheumatism, chronic pharyngitis and arthritis
Xiujuan Wang, Dongtian Liu, Liyan Xiong, Bianba Dunzhu, Liqing Zhang, Wansheng Chen, Yingbo Yang, Ying Xiao, Lianna Sun   +8 more
doaj   +1 more source

Spiro scaffolds: synthetic strategies and pharmacological activities

Many polycyclic compounds have been reported to possess a significant pharmacological activity, among them spirocyclic derivatives. Natural alkaloids containing spiro-carbons are widely distributed in nature and exhibit diverse pharmacological properties,
Bouhaoui, Abderrazzak, Bouissane, Latifa, Eddahmi, Mohammed, Moumad, Aziz, Catto, Marco   +4 more
core   +1 more source