Results 31 to 40 of about 519,313 (296)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Nursing and Midwifery Studies, 2016 Background Pharmacological knowledge and medication management skills of student nurses greatly depend on the clinical nurse educators’ performance in this critical issue.
Ghamari Zare, Adib-Hajbaghery
doaj +1 more source
Journal of Analytical Methods in Chemistry, 2022 Mice are the most frequently used animals in pharmacokinetic studies; however, collecting series of blood samples from mice is difficult because of their small sizes and tiny vessels.
Ying Xu +13 more
doaj +1 more source
Moxonidine: Pharmacology, Clinical Pharmacology and Clinical Profile
Blood Pressure, 1998 Management strategies in hypertension evolve in response to an increased understanding of underlying pathophysiological processes and developments and refinements in drug treatments. Recent research has identified the regulatory role of the imidazoline (I1) receptor in sympathetic outflow and blood pressure regulation and this has led to the ...
openaire +2 more sources
, 2017 The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5-fluorouracil and capecitabine ...
Schellens, Jan H M +35 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Clinical pharmacology in the UK, c. 1950–2000: influences and institutions
, 2008 The history of clinical pharmacology in the UK over the last half of the twentieth century is largely untold. Many important new drugs were developed and brought to market in the 1950s and 1960s ensuring the need for more systematic knowledge of drug ...
Reynolds, LA, Tansey, EM
core +1 more source
Zdravniški Vestnik, 2006 Backgrounds: Clinical pharmacology has developed in the second half of 20th century and is now part of an undergraduate and postgraduate studies, being taught as a separate subject on most universities in developed countries.
Jože Drinovec
doaj
Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer [PDF]
, 2017 Wee1 is a protein kinase that regulates the G2checkpoint and prevents entry into mitosis in response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 serine/threonine protein kinases that coordinate the progression through the cell cycle.
Geenen, Jill J. +3 more
core +1 more source