Clinical pharmacology of deoxycoformycin [PDF]
Blood, 1981 Deoxycoformycin (DCF) is an inhibitor of adenosine deaminase (ADA). Twenty-one courses of DCF were administered to 13 patients ranging in age from 15 to 78 yr. Eight patients had T-cell disorders, and five patients had non-T-cell malignancies. The i.v. bolus dose was escalated from 5 to 30 mg/sq m/day, and the duration of the courses ranged from 1 to 5
DW Kufe, PP Major, Ram P. Agarwal
openaire +4 more sources
A comparative human rights analysis of laws and policies for adolescent contraception in Uganda and Kenya [PDF]
, 2022 BACKGROUND: Improving access to adolescent contraception information and services is essential to reduce unplanned adolescent pregnancies and maternal mortality in Uganda and Kenya, and attain the SDGs on health and gender equality. This research studies
Afd Pharmacoepi & Clinical Pharmacology +9 more
core +2 more sources
A novel method for predicting the budget impact of innovative medicines:validation study for oncolytics [PDF]
, 2020 Background High budget impact (BI) estimates of new drugs have led to decision-making challenges potentially resulting in restrictions in patient access. However, current BI predictions are rather inaccurate and short term.
Afd Pharmacoepi & Clinical Pharmacology +8 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Translational pharmacology: role and its impact [PDF]
, 2018 Translational Pharmacology is a newly evolved branch as an extension of clinical pharmacology. Translational Pharmacology aims to move the results of the molecular pharmacological research to the patient level, which is focussed on developing the new ...
Kumar, Sumit, Sattigeri, Bhagya M.
core +2 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Integration of computer-simulated practical exercises into undergraduate medical pharmacology education at Mulungushi University, Zambia [PDF]
Journal of Educational Evaluation for Health Professions, 2020 Purpose This study was conducted to determine whether a computer simulation of practical exercises in undergraduate medical pharmacology led to the realization of the intended learning outcomes.
Christian Chinyere Ezeala
doaj +1 more source
Comparison of pharmacist evaluation of medication orders with predictions of a machine learning model [PDF]
arXiv, 2020 The objective of this work was to assess the clinical performance of an unsupervised machine learning model aimed at identifying unusual medication orders and pharmacological profiles. We conducted a prospective study between April 2020 and August 2020 where 25 clinical pharmacists dichotomously (typical or atypical) rated 12,471 medication orders and ...
arxiv
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design [PDF]
arXiv, 2020 If explicit, formal consideration of clinical pharmacology at all informs the design and conduct of modern oncology dose-finding trials, the designs themselves hardly attest to this. Yet in conducting a trial, investigators affirm that they hold reasonable expectations of participant safety - expectations that necessarily depend on beliefs about how ...
arxiv