Results 161 to 170 of about 6,245 (194)
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Pharmacometrics in Dermatology
2014There is increasing recognition of the impact of pharmacometrics in improving drug development and influencing regulatory decision making across different therapeutic areas. However, the field of dermatology remains largely underserved by pharmacometrics with limited number of examples illustrating the application of modeling and simulation methods in ...
Vivek S. Purohit +2 more
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Pharmacometrics and Tuberculosis
2014There are very few effective tuberculosis (TB) drugs available, and for active disease, they must be used in combinations of four or more drugs and for many months. Treatment guidelines are very helpful, and include considerable empiric evidence.
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2014
Pharmacometric approaches applied to the design and analysis of pediatric clinical pharmacology trials are essential for providing informative dosing guidance in children. This chapter reviews the key questions that define the proper implementation of pharmacometrics in the study of pediatric populations, examines historical, current, and optimal ...
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Pharmacometric approaches applied to the design and analysis of pediatric clinical pharmacology trials are essential for providing informative dosing guidance in children. This chapter reviews the key questions that define the proper implementation of pharmacometrics in the study of pediatric populations, examines historical, current, and optimal ...
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Pharmacometrics of Viral Infections
2014Antiviral drugs play a crucial role in the treatment of human infections caused by viral pathogens. In order for antiviral therapy to be efficacious, the optimal dose and dosing interval for each compound must be identified. Optimal dosage regimens are defined as regimens that maximize inhibition of viral replication, prevent the emergence of ...
George L. Drusano, Ashley N. Brown
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Pharmacometrics in Bacterial Infections
2014Pharmacometrics plays an important role in rational dosing design of antimicrobial therapy by defining the relationship between dose, dosing interval, drug concentration, bacterial response, infection outcome, and toxicity, as well as the variability surrounding these variables.
Sherwin K. B. Sy, Hartmut Derendorf
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Defining the Future of Pharmacometrics: The American Society of Pharmacometrics
The Journal of Clinical Pharmacology, 2010Marc, Pfister +5 more
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Pharmacometrics: The Already-Present Future of Precision Pharmacology
Therapeutic Innovation and Regulatory Science, 2022Lorena Cera Bandeira +2 more
exaly
Pharmacometrics in Psychiatric Diseases
2014Psychiatric disorders may have a huge impact on someone’s personal functioning as well as on the person’s interaction with others. Treatment with psychoactive drugs may be helpful, but there is much room for improvement. To this end, we need much more insight into the disease processes, the fate of psychoactive drugs in the body (particularly the brain)
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