Results 151 to 160 of about 6,245 (194)
Pharmacometrics in tuberculosis: progress and opportunities [PDF]
International Journal of Antimicrobial Agents, 2022 Tuberculosis (TB) remains one of the leading causes of death by a communicable agent, infecting up to one-quarter of the world's population, predominantly in disadvantaged communities. Pharmacometrics employ quantitative mathematical models to describe the relationships between pharmacokinetics and pharmacodynamics, and to predict drug doses, exposures
Justin J Wilkins +2 more
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The Relevance of Epigenetics and Epigenomics to Pharmacometrics
Epigenomics, 2023Jacob Peedicayil, Blessed W Aruldhas
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Therapeutic Innovation & Regulatory Science, 2019
Pharmacometrics have advanced from compartmental analysis to noncompartmental analysis and population pharmacokinetics that require complicated mathematical programs. These sophisticated mathematical analyses determine not only the usual pharmacometric measures of clearance and volume of distribution but also the effects of covariates on these measures.
Xiaoxi Liu, Robert M. Ward
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Pharmacometrics have advanced from compartmental analysis to noncompartmental analysis and population pharmacokinetics that require complicated mathematical programs. These sophisticated mathematical analyses determine not only the usual pharmacometric measures of clearance and volume of distribution but also the effects of covariates on these measures.
Xiaoxi Liu, Robert M. Ward
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The Journal of Clinical Pharmacology, 2010
This special issue of the Journal of Clinical Pharmacology is dedicated to pharmacometrics, covering topics related to methodological research, application to decisions, standardization, PhRMA survey, and growth strategy. Innovative methodological and technological advances in analyzing disease, drug, and trial data have equipped pharmacometricians ...
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This special issue of the Journal of Clinical Pharmacology is dedicated to pharmacometrics, covering topics related to methodological research, application to decisions, standardization, PhRMA survey, and growth strategy. Innovative methodological and technological advances in analyzing disease, drug, and trial data have equipped pharmacometricians ...
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Pharmacometrics in Pain Management
The Biomedical & Life Sciences Collection, 2014© American Association of Pharmaceutical Scientists 2014 S. Schmidt, H. Derendorf (eds.), Applied Pharmacometrics, AAPS Advances in the Pharmaceutical Sciences Series 14, DOI 10.1007/978-1-4939-1304-6_18 Y. Wang () · P. Ji · J. Liu · H. Zhu Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903
Yaning Wang, Jiang Liu, Hao Zhu, Ping Ji
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Pharmacometrics in Pregnancy: An Unmet Need
Annual Review of Pharmacology and Toxicology, 2014Pregnant women and their fetuses are orphan populations with respect to the safety and efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion (ADME) changes during pregnancy can significantly affect drug pharmacokinetics (PK) and may necessitate dose adjustment.
Ke, Alice Ban +3 more
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Applications of pharmacometrics in drug development
Advanced Drug Delivery ReviewsThe last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches.
Yuan Xiong +2 more
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Pharmacometrics and Systems Pharmacology 2030
Clinical Pharmacology & Therapeutics, 2019In 2012, a new journal was launched from the ASCPT family, CPT: Pharmacometrics and Systems Pharmacology (PSP) as both quantitative system pharmacology (QSP) and pharmacometrics were growing fields in pharmacology, drug development, and drug use. In this Perspective, the present editors and associate editors of PSP want to share their strategic vision ...
France, Mentré +9 more
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Pharmacometrics of Hyperlipidemia
2014Arteriosclerosis of the coronary and peripheral vasculature is the undisputed leading cause of death worldwide resulting from cardiovascular disease, peripheral vascular disease, and stroke. Lipoproteins represent a surrogate for one of the significant cardiovascular risk factors, and mathematical models to understand lipoprotein kinetics have been ...
Maurice G. Emery +2 more
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2021
Στις μέρες μας, η μαθηματική μοντελοποίηση έχει αποδειχθεί ότι αποτελεί ένα πολύ σημαντικό στοιχείο της κλινικής φαρμακευτικής. Στην παρούσα διατριβή, τεχνικές πληθυσμιακής μοντελοποίησης, παλινδρόμησης, προσομοίωσης και μηχανικής μάθησης εφαρμόστηκαν για την βελτιστοποίηση δoσολογικών σχημάτων, για να διερευνηθεί η επίδραση της γαστρικής κένωσης και ...
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Στις μέρες μας, η μαθηματική μοντελοποίηση έχει αποδειχθεί ότι αποτελεί ένα πολύ σημαντικό στοιχείο της κλινικής φαρμακευτικής. Στην παρούσα διατριβή, τεχνικές πληθυσμιακής μοντελοποίησης, παλινδρόμησης, προσομοίωσης και μηχανικής μάθησης εφαρμόστηκαν για την βελτιστοποίηση δoσολογικών σχημάτων, για να διερευνηθεί η επίδραση της γαστρικής κένωσης και ...
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