Results 201 to 210 of about 37,292 (264)

In silico comparative proteomics and structural analysis of Theileria species reveals conserved druggable targets for anti-theilerial therapy. [PDF]

BMC Microbiol
Khan H, Akbar I, Ibrahim U, Lun H, Liu B, Malik A, Ola MS, Xu G, Khan A, Huang K.   +9 more
europepmc   +1 more source

Identification of novel HIF2α inhibitors: a structure-based virtual screening approach. [PDF]

J Enzyme Inhib Med Chem
Zhou S, Yin S, Yang S, Wang Y, Feng P.
europepmc   +1 more source

Bioinformatics and computational exploration of novel inhibitors targeting KRAS G12C mutant protein in lung adenocarcinoma. [PDF]

Discov Oncol
Tang G, Ding H, Gong Y.
europepmc   +1 more source

A multi-stage computational pipeline and <i>in vitro</i> validation for the discovery of small-molecule translation inhibitors targeting the bacterial ribosome. [PDF]

RSC Adv
Yuce M, Koman E, Sungur FA, Yazgan-Karatas A, Kurkcuoglu O.   +4 more
europepmc   +1 more source

Deploying the high-throughput virtual screening (HTVS) approach for the identification of new lactate dehydrogenase (LDH) inhibitors with anticancer assets. [PDF]

Sci Rep
Huang Y, Benni S, Yadav UP, Babu MA, Verma A, Singh TG, Bansal N, Zhang Y.   +7 more
europepmc   +1 more source

Multicomplex Pharmacophore Modeling of Estrogen Receptors Suggests the Probable Repurposing of Procaterol as an Antiproliferative Agent Against Breast Cancer Cells. [PDF]

Int J Mol Sci
Vazquez-Mendoza LH, Mendoza-Figueroa HL, Jacobo-Herrera NJ, Bakalara N, González-Juárez DE, Correa-Basurto J, García-Vázquez JB.   +6 more
europepmc   +1 more source

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The Desferrithiocin Pharmacophore

Journal of Medicinal Chemistry, 1994
The (S)-desferrithiocin (DFT) skeleton is shown to be a useful pharmacophore on which to design orally effective iron chelators. While the study clearly indicates that formal reduction of the desazadesmethyldesferrithiocin thiazoline to a thiazolidine (6), expansion of the desmethyldesferrithiocin thiazoline to a thiazine (7), or substitution of the ...
R J, Bergeron, C Z, Liu, J S, McManis, M X, Xia, S E, Algee, J, Wiegand   +5 more
openaire   +2 more sources

Spirooxindoles as Potential Pharmacophores

Mini-Reviews in Medicinal Chemistry, 2017
The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
Siva S, Panda, Rachel A, Jones, Praveen, Bachawala, Prabhu P, Mohapatra   +3 more
openaire   +3 more sources