Results 201 to 210 of about 41,275 (293)

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis. [PDF]

Nat Commun
Passmore M, Jian X, Zhao X, de Los Santos ELC, Roberts DM, Lewandowski JR, Jenner M, Alkhalaf LM, Challis GL.   +8 more
europepmc   +1 more source

Synthesis and Hepatotoxicity Evaluation of Paeonol Clofibrate

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
CF‐Paeonol, a molecular hybrid of clofibric acid and paeonol, retains lipid‐lowering activity while producing markedly less hepatic injury than clofibrate (CF) in mice. Its benefits are accompanied by improved bile acid homeostasis, reduced oxidative stress and inflammation, decreased YY1 expression, and increased FXR expression, supporting molecular ...
Haoyu Tu, Ling Ding, Jing Zheng, Yichen Yang, Xin Chen, Yumiao Song, Xinyi Shi, Chuwen Wang, Xinya Xu, Jiping Liu, Yundong Xie   +10 more
wiley   +1 more source

AI-assisted design and virtual profiling of targeted degraders for pancreatic cancer therapy via PROTAC technology. [PDF]

Am J Cancer Res
Du B, Wang K, Wu Z, Qiu S, Konstantinos FD, Yu S.   +5 more
europepmc   +1 more source

Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan, Meenakshi Kaira, Sucheta Singh, Hrithik Dey, Kailash C. Pandey   +4 more
wiley   +1 more source

Graphene Oxide-Hydroxyapatite Nanocomposite Coatings and Extracellular Matrix Protein Interactions for Enhanced Osseointegration in Dental Implants. [PDF]

J Cell Mol Med
Saini RS, Binduhayyim RIH, Dermawan D, Kanji MA, Quadri SA, Heboyan A.   +5 more
europepmc   +1 more source

GC–MS‐Based Phytochemical Profiling and Integrated Evaluation of Antioxidant, Antibacterial, and In Silico Studies of Kumaun Himalayan Strobilanthes Species

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Himalayan Strobilanthes species: phytochemical profiling, bioactivities, and In silico Studies. ABSTRACT Five Strobilanthes species indigenous to the Kumaun Himalayan region of Uttarakhand, India, have been historically employed in traditional medicine to treat bacterial infections, inflammatory conditions, and respiratory ailments, but remain largely ...
Sakshi Negi, Ravendra Kumar, Vaishnavi Rawat, Pooja Bargali, Aashish Kumar Sagar, Stefania Garzoli, Riddhiman Lahiri, Shilpi Rawat, Avdhesh Kumar, Manmohan Singh Rawat, Jolanta Maslowiecka, Valery A. Isidorov, Dharmendra S. Rawat   +12 more
wiley   +1 more source

Spatial relationships between the pharmacophores of endomorphin-2: a comparative study of stereoisomers

Open Chemistry, 2012
Leitgeb Balázs
doaj   +1 more source

Vitamin B₁-catalyzed green synthesis and antiplasmodial evaluation of 2-amino-7-hydroxy-4-aryl-4<i>H</i>-chromene-3-carbonitrile derivatives: computational insights into putative PfNDH2 targeting. [PDF]

RSC Adv
Patil P, Bagul A, Kumar M, Tufail A, Alraey Y, Alshammari M, Patil S, Nandre S, Dubey A.   +8 more
europepmc   +1 more source

Synthesis and Antifungal Activities of Perillyl Alcohol Based 1,3,4‐Thiadiazole‐Thioether Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of perillyl alcohol‐derived 1,3,4‐thiadiazole‐thioether compounds were designed, synthesized, and evaluated for their antifungal activities. Compound V15 was identified as the most potent derivative, demonstrating superior efficacy against G.
Yanlin Xiong, Yun Zhang, Yucheng Cui, Meijuan Hu, Meifang Zhuo, Wengui Duan, Qijin Mo   +6 more
wiley   +1 more source

CReM-pharm: de novo 3D pharmacophore-based design with synthetic accessibility awareness. [PDF]

J Cheminform
Denzler A, Sriramulu DK, Pecha J, Polishchuk P.   +3 more
europepmc   +1 more source