Results 1 to 10 of about 325,427 (396)

Lack of general learning ability factor in a rat test battery measuring a wide spectrum of cognitive domains [PDF]

Journal of Integrative Neuroscience, 2022
Objective: In the framework of a larger project aiming to test putative cognitive enhancer drugs in a system with improved translational validity, we established a rodent test battery, where different, clinically relevant cognitive domains were ...
Ferenc Kassai, Aliz J. Ernyey, Kata Kozma, Imola Plangár, István Gyertyán   +4 more
doaj   +1 more source

The Investigation of Combined Na+/Ca2+ Exchanger and the L-type Ca2+- Channel Inhibition in Langendorff-Perfused Isolated Guinea Pig Hearts [PDF]

Romanian Journal of Cardiology, 2021
Objective: The sodium/calcium exchanger (NCX) and the L-type Ca2+-channel (LTCC) are nowadays considered the major transmembrane transport mechanisms that control Ca2+ homeostasis.
János PROROK, Annamária VEISBART, Dóra LIPKA, Norbert JOST   +3 more
doaj   +1 more source

Patient Perspectives on the Use of Digital Technology to Help Manage Cystic Fibrosis

Pulmonary Medicine, 2023
Background. Digital health technologies (DHTs) have shown potential to improve health outcomes through improved medication adherence in different disease states.
Alexandre H. Watanabe, Connor Willis, Russell Ragsdale, Joseph Biskupiak, Karlene Moore, Diana Brixner, David Young   +6 more
doaj   +1 more source

Role of Traditional Cardiovascular Risk Factors after Initiation of Statin Therapy: A PharmLines Inception Cohort Study

Cardiovascular Therapeutics, 2022
Background. Multiple studies and meta-analyses examined the role of traditional risk factors for cardiovascular events in statin treatment-naive patients.
Dennis Steenhuis, Stijn de Vos, Jens Bos, Eelko Hak   +3 more
doaj   +1 more source

Forensic and Pharmaceutical Risks in the Organization of Pharmacotherapy of Covid, Post-Covid and Long-Covid Disorders. COVID-19 and Vaccination Practice Standards.

SSP Modern Pharmacy and Medicine, 2022
The COVID-19 pandemic has strained the healthcare system. It is important to consider forensic and pharmaceutical risks in the organization of vaccination practices and pharmacotherapy of covid, post-covid and long-covid disorders.
V. Shapovalova
semanticscholar   +1 more source

Performance of the intracerebroventricularly injected streptozotocin Alzheimer’s disease model in a translationally relevant, aged and experienced rat population

Scientific Reports, 2022
The intracerebroventricularly (icv) injected streptozotocin (STZ) induced brain state is a widely used model of sporadic Alzheimer-disease (AD). However, data have been generated in young, naive albino rats.
Attila Gáspár, Barbara Hutka, Aliz Judit Ernyey, Brigitta Tekla Tajti, Bence Tamás Varga, Zoltán Sándor Zádori, István Gyertyán   +6 more
doaj   +1 more source

Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy

Science Advances, 2022
Electroresponsive and synergistic brain-targeting nanoparticles improve efficacy of pharmacotherapy for epilepsy.
Di Wu, Fan Fei, Qi Zhang, Xia Wang, Yiwei Gong, Xiaojie Chen, Yuyi Zheng, Bei Tan, Ceng-lin Xu, Hujun Xie, Wenjun Fang, Zhong Chen, Yi Wang   +12 more
semanticscholar   +1 more source

Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy

Cancer Cell International, 2023
Background KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnesylation and geranylgeranylation ...
Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Kana Kishimoto, Honoka Takefuji, Yuzuki Taniwaki, Misa Ueda, Tadafumi Hoshida, Kazufumi Tanabe, Shozo Nishida   +9 more
doaj   +1 more source

Pharmacotherapy for Nocturia [PDF]

Current Urology Reports, 2018
To assess current pharmacological principles used for treatment of nocturia/nocturnal polyuria.The pathophysiology of nocturia is often multifactorial, but two main mechanisms have been identified, occurring alone or in combination: low functional bladder capacity and nocturnal polyuria.
Andersson, Karl Erik, Van Kerrebroeck, Philip   +1 more
openaire   +3 more sources

Pharmacotherapy for Fibromyalgia [PDF]

Frontiers in Pharmacology, 2011
Fibromyalgia (FM) is a chronic disorder characterized by multifocal pain and other associated somatic symptoms including fatigue, insomnia, cognitive/memory problems, and even psychological distress. It appears that 2-4% of the general population suffers from FM.
Howard S. Smith, Donna Bracken, Joshua M. Smith   +2 more
openaire   +4 more sources