Results 1 to 10 of about 140,892 (150)

Lack of general learning ability factor in a rat test battery measuring a wide spectrum of cognitive domains [PDF]

Journal of Integrative Neuroscience, 2022
Objective: In the framework of a larger project aiming to test putative cognitive enhancer drugs in a system with improved translational validity, we established a rodent test battery, where different, clinically relevant cognitive domains were ...
Ferenc Kassai, Aliz J. Ernyey, Kata Kozma, Imola Plangár, István Gyertyán   +4 more
doaj   +1 more source

Role of Traditional Cardiovascular Risk Factors after Initiation of Statin Therapy: A PharmLines Inception Cohort Study

Cardiovascular Therapeutics, 2022
Background. Multiple studies and meta-analyses examined the role of traditional risk factors for cardiovascular events in statin treatment-naive patients.
Dennis Steenhuis, Stijn de Vos, Jens Bos, Eelko Hak   +3 more
doaj   +1 more source

The Investigation of Combined Na+/Ca2+ Exchanger and the L-type Ca2+- Channel Inhibition in Langendorff-Perfused Isolated Guinea Pig Hearts [PDF]

Romanian Journal of Cardiology, 2021
Objective: The sodium/calcium exchanger (NCX) and the L-type Ca2+-channel (LTCC) are nowadays considered the major transmembrane transport mechanisms that control Ca2+ homeostasis.
János PROROK, Annamária VEISBART, Dóra LIPKA, Norbert JOST   +3 more
doaj   +1 more source

Patient Perspectives on the Use of Digital Technology to Help Manage Cystic Fibrosis

Pulmonary Medicine, 2023
Background. Digital health technologies (DHTs) have shown potential to improve health outcomes through improved medication adherence in different disease states.
Alexandre H. Watanabe, Connor Willis, Russell Ragsdale, Joseph Biskupiak, Karlene Moore, Diana Brixner, David Young   +6 more
doaj   +1 more source

Performance of the intracerebroventricularly injected streptozotocin Alzheimer’s disease model in a translationally relevant, aged and experienced rat population

Scientific Reports, 2022
The intracerebroventricularly (icv) injected streptozotocin (STZ) induced brain state is a widely used model of sporadic Alzheimer-disease (AD). However, data have been generated in young, naive albino rats.
Attila Gáspár, Barbara Hutka, Aliz Judit Ernyey, Brigitta Tekla Tajti, Bence Tamás Varga, Zoltán Sándor Zádori, István Gyertyán   +6 more
doaj   +1 more source

Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy

Cancer Cell International, 2023
Background KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnesylation and geranylgeranylation ...
Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Kana Kishimoto, Honoka Takefuji, Yuzuki Taniwaki, Misa Ueda, Tadafumi Hoshida, Kazufumi Tanabe, Shozo Nishida   +9 more
doaj   +1 more source

Knowledge and perception of biosimilars in ambulatory care: a survey among Belgian community pharmacists and physicians

Journal of Pharmaceutical Policy and Practice, 2021
Background With the approval of biosimilars for subcutaneously administered products, such as adalimumab, etanercept and insulin, biosimilars become increasingly available in ambulatory care.
Liese Barbier, Yannick Vandenplas, Steven Simoens, Paul Declerck, Arnold G. Vulto, Isabelle Huys   +5 more
doaj   +1 more source

Impact of type of anticoagulant on clinical outcomes in cancer patients who had atrial fibrillation

Scientific Reports, 2023
To date, evidence on optimal anticoagulant options in patients with AF who concurrently have active cancer remains elusive. To describe anticoagulant patterns and clinical outcomes among patients with a concomitant diagnosis of AF and cancer.
Chatree Chai-Adisaksopha, Alexandre H. Watanabe, Piyameth Dilokthornsakul, Leenhapong Navaravong, Daniel M. Witt, Nathorn Chaiyakunapruk   +5 more
doaj   +1 more source

Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion

Cells, 2020
Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of ‘hidden cardiotoxicity’ is defined as cardiotoxicity of a drug that manifests in ...
Gábor B. Brenner, András Makkos, Csilla Terézia Nagy, Zsófia Onódi, Nabil V. Sayour, Tamás G. Gergely, Bernadett Kiss, Anikó Görbe, Éva Sághy, Zoltán S. Zádori, Bernadette Lázár, Tamás Baranyai, Richárd S. Varga, Zoltán Husti, András Varró, László Tóthfalusi, Rainer Schulz, István Baczkó, Zoltán Giricz, Péter Ferdinandy   +19 more
doaj   +1 more source

IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH

Scientific Reports, 2023
Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging.
Dániel Kucsera, Viktória E. Tóth, Nabil V. Sayour, Tamás Kovács, Tamás G. Gergely, Mihály Ruppert, Tamás Radovits, Alexandra Fábián, Attila Kovács, Béla Merkely, Péter Ferdinandy, Zoltán V. Varga   +11 more
doaj   +1 more source