Results 11 to 20 of about 2,739,138 (153)

Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson’s Disease via the Nrf2/Keap1 Pathway

Pharmaceuticals, 2022
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and there is still no cure for it. PD is characterized by the degeneration of dopaminergic neurons, and oxidative stress has been considered an important pathological mechanism.
Qiu-Xu Chen, Ling Zhou, Tao Long, Da-Lian Qin, Yi-Ling Wang, Yun Ye, Xiao-Gang Zhou, Jian-Ming Wu, An-Guo Wu   +8 more
doaj   +1 more source

An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification

BMC Complementary Medicine and Therapies, 2022
Background Compound Kushen Injection (CKI) is a Chinese patent drug that exerts curative effects in the clinical treatment of hepatocellular carcinoma (HCC).
Shan Lu, Ziqi Meng, Yingying Tan, Chao Wu, Zhihong Huang, Jiaqi Huang, Changgeng Fu, Antony Stalin, Siyu Guo, Xinkui Liu, Leiming You, Xiaojiaoyang Li, Jingyuan Zhang, Wei Zhou, Xiaomeng Zhang, Miaomiao Wang, Jiarui Wu   +16 more
doaj   +1 more source

A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ

Communications Biology, 2022
The co-crystal berberine-ibuprofen is an effective agent for treating obesity through a reduction of the activity of the non-canonical I κB kinases, IKKε and TBK1.
Man Wang, Rong Xu, Xiaoli Liu, Ling Zhang, Siyan Qiu, Yuting Lu, Peng Zhang, Ming Yan, Jing Zhu   +8 more
doaj   +1 more source

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

Natural Products and Bioprospecting, 2020
One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi.
Xiu-Rong Wu, Yi Shen, Shu-Jun Cui, Xiao-Lei Luo, Chao-Jiang Xiao, Bei Jiang   +5 more
doaj   +1 more source

Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking

Chinese Medicine, 2023
Background Yinzhihuang granules (YZHG) is a commonly used Chinese patent medicine for the treatment of liver disease. However, the mechanism of YZHG in alcoholic liver disease (ALD) is still unclear. Methods This study combined liquid chromatography-mass
Yingying Tan, Fanqin Zhang, Xiaotian Fan, Shan Lu, Yingying Liu, Zhishan Wu, Zhihong Huang, Chao Wu, Guoliang Cheng, Bing Li, Jiaqi Huang, Antony Stalin, Wei Zhou, Jiarui Wu   +13 more
doaj   +1 more source

Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions

Frontiers in Pharmacology, 2019
The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension compared with a true solution, which may in turn affect the therapeutic effect of the drug.
Qi Yuan, Yanling Wang, Rufeng Song, Xianqiao Hou, Keke Yu, Jiaojiao Zheng, Juanmei Zhang, Xiaohui Pu, Jihong Han, Lanlan Zong   +9 more
doaj   +1 more source

Siwei Jianbu decoction improves painful paclitaxel-induced peripheral neuropathy in mouse model by modulating the NF-κB and MAPK signaling pathways

Regenerative Medicine Research, 2020
Background: Paclitaxel, a commonly used chemotherapeutic agent, is usually associated with peripheral neuropathy. Paclitaxel induced peripheral neuropathy (PIPN) can be dose limiting and may have detrimental influence on patients' quality of life ...
Suo Jinshuai, Wang Man, Zhang Peng, Lu Yuting, Xu Rong, Zhang Ling, Qiu Siyan, Zhang Qiuyan, Qian Yangyan, Meng Jing, Zhu Jing   +10 more
doaj   +1 more source

Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution

Nanoscale Research Letters, 2019
Bufalin, derived from Venenum Bufonis, exerts antitumor effects but has low bioavailability and adverse effects when administered as a single agent.
Jiani Yuan, Cheng Zeng, Wei Cao, Xuanxuan Zhou, Yang Pan, Yanhua Xie, Yifang Zhang, Qian Yang, Siwang Wang   +8 more
doaj   +1 more source

A configurable computer simulation model for reducing patient waiting time in oncology departments [PDF]

Health Systems (2022), 2020
Nowadays, the increase in patient demand and the decline in resources are lengthening patient waiting times in many chemotherapy oncology departments. Therefore, enhancing healthcare services is necessary to reduce patient complaints. Reducing the patient waiting times in the oncology departments represents one of the main goals of healthcare manager ...
arxiv   +1 more source

PharmMT: A Neural Machine Translation Approach to Simplify Prescription Directions [PDF]

Findings of EMNLP (2020) 2785--2796, 2022
The language used by physicians and health professionals in prescription directions includes medical jargon and implicit directives and causes much confusion among patients. Human intervention to simplify the language at the pharmacies may introduce additional errors that can lead to potentially severe health outcomes.
arxiv   +1 more source