Results 41 to 50 of about 1,331,680 (246)

Universal Dynamics of Phase-Field Models for Dendritic Growth

, 1998
We compare time-dependent solutions of different phase-field models for dendritic solidification in two dimensions, including a thermodynamically consistent model and several ad hoc models.
A. A. Wheeler, A. Karma, A. Karma, A. Karma, D. A. Kessler, G. Caginalp, G. Caginalp, G. Caginalp, G. Caginalp, J. A. Warren, J. B. Collins, J. Langer, J. S. Langer, J. S. Langer, Jonathan Dantzig, M. E. Glicksman, M. Fabbri, N. Provatas, N. Provatas, Nigel Goldenfeld, Nikolas Provatas, O. Penrose, R. Kobayashi, S.-C. Huang, S.-L. Wang, S.-L. Wang, Yung-Tae Kim   +26 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Generalized Phase-Field System

Journal of Mathematical Analysis and Applications, 1999
The authors consider the problem \((\Omega\) bounded domain in \(\mathbb{R}^N\) with \(C^2\)-boundary) \[ \begin{aligned} {\partial u\over\partial t}+l {\partial \varphi\over\partial t}=\Delta u+f(x,t), \quad & (x,t)\in Q:=\Omega \times(0,T),\\ {\partial\varphi \over\partial t}=\Delta\varphi+ F(x,t,\varphi) +u,\quad & (x,t)\in Q,\\ {\partial u\over ...
Moroşanu, Costică, Motreanu, Dumitru
openaire   +1 more source

Phase-Field Model of Mode III Dynamic Fracture

, 2001
We introduce a phenomenological continuum model for mode III dynamic fracture that is based on the phase-field methodology used extensively to model interfacial pattern formation.
A. Karma, A. Omeltchenko, Alain Karma, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. Holland, David A. Kessler, E. Johnson, E. Sharon, E. Sharon, F. F. Abraham, G. Caginalp, G. I. Barenblatt, Herbert Levine, I. S. Aranson, J. B. Collins, J. Fineberg, J. Fineberg, J. Fineberg, J. S. Langer, J. S. Langer, J. S. Langer, K. Broberg, K. Ravi-Chandar, L. B. Freund, L. I. Slepyan, L. I. Slepyan, L. I. Slepyan, M. Marder, M. Marder, N. Provatas, P. Gumbsch, S. J. Zhou, Sh. A. Kulamekhtova, T. Cramer, T. Cramer, William H. Press, X.-P. Xu, Z. Pazant   +40 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Phase-Field Model of Spiral Dendritic Growth

, 1996
Domains of condensed-phase monolayers of chiral molecules exhibit a variety of interesting nonequilibrium structures when formed via pressurization.
A. A. Wheeler, A. Boesch, A. Karma, C. M. Knobler, E. Ben-Jacob, E. Brener, G. B. McFadden, G. Caginalp, Herbert Levine, J. B. Collins, J. S. Langer, J. V. Selinger, K. Stine, O. Penrose, R. Kam, R. Kobayashi, R. Kupferman, R. Kupferman, R. Viswanathan, R. Weis, Royce Kam, T. Fischer, V. M. Kaganer, W. M. Heckl, Xiao-Min Yang   +24 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Sharp-Interface Limit of a Fluctuating Phase-Field Model

, 2005
We present a derivation of the sharp-interface limit of a generic fluctuating phase-field model for solidification. As a main result, we obtain a sharp-interface projection which presents noise terms in both the diffusion equation and in the moving ...
L. Ramírez-Piscina, R. Benítez, R. González-Cinca, T. A. Cherepanova   +3 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source