Results 61 to 70 of about 1,331,680 (246)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dynamic model and stationary shapes of fluid vesicles

, 2006
A phase-field model that takes into account the bending energy of fluid vesicles is presented. The Canham-Helfrich model is derived in the sharp-interface limit. A dynamic equation for the phase-field has been solved numerically to find stationary shapes
A. Hernández-Machado, Alava, Allain, Biben, Cahn, Canham, Du, Du, Edidin, Evans, F. Campelo, Goldstein, Gompper, Helfrich, Jülicher, Kraus, Kumar, Laradji, Noguchi, Noguchi, Prost, Ringsdorf, Safran, Seifert, Seifert, Seifert, Seifert, Sens, Taniguchi, Tsafrir, Tsafrir, Yeung, Zimmerberg   +32 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Phase-field approach to heterogeneous nucleation

, 2002
We consider the problem of heterogeneous nucleation and growth. The system is described by a phase field model in which the temperature is included through thermal noise.
A. A. Wheeler, A. E. Kolmogorov, A. E. Lobkovsky, A. Karma, A. Roy, B. Nestler, C. Castellano, C. W. Price, H. J. Frost, H.-J. Jou, I. Steinbach, J. B. Collins, J. D. Gunton, J. Olivares, J. S. Im, K. R. Elder, K. R. Elder, K. R. Elder, M. Avrami, M. C. Weinberg, M. Castro, M. Castro, M. Dubé, M. Grant, M. Karttunen, Mario Castro, P. C. Hohenberg, R. A. Ramos, R. Becker, R. Bergmann, R. D. Doherty, R. Folch, R. Folch, R. Kobayashi, R. Kobayashi, R. Kobayashi, R. W. Cahn, V. G. Karpov, V. G. Karpov, W. A. Johnson, X. Y. Liu, Y. Enomoto, Y. Uemoto, Ya. B. Zeldovich   +43 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Multi-Phase-Field Approach

, 2023
AbstractIn this chapter the extension of a phase-field model for two phases to multiple phases is presented. This relates to the treatment of triple lines and junctions between several phases, or grains in a multicrystalline structure. The conservation constraint of the sum of all fields in one material point is realized using a Lagrange formalism. The
Ingo Steinbach, Hesham Salama
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Entropy production in phase field theories

, 2019
Allen-Cahn (Ginzburg-Landau) dynamics for scalar fields with heat conduction is treated in rigid bodies using a non-equilibrium thermodynamic framework with weakly nonlocal internal variables.
A Berezovski, A Berezovski, Arkadi Berezovski, GA Maugin, H Emmerich, Hans Christian Öttinger, JW Cahn, JW Cahn, MG Gurtin, O Penrose, P Ván, P Ván, PC Hohenberg, PC Hohenberg, RF Sekerka, SR Groot de   +15 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Herschel-ATLAS: Blazars in the science demonstration phase field [PDF]

, 2010
To investigate the poorly constrained sub-mm counts and spectral properties of blazars we searched for these in the Herschel-ATLAS (H-ATLAS) science demonstration phase (SDP) survey catalog.
González-Nuevo, J., Vieira, J. D.
core