Results 141 to 150 of about 1,736,707 (316)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Quantum theory of reactive scattering in phase space
, 2010 We review recent results on quantum reactive scattering from a phase space perspective. The approach uses classical and quantum versions of normal form theory and the perspective of dynamical systems theory.
Brandas, E +17 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Quantitative and Qualitative Analysis of Aircraft Round-Trip Times Using Phase Type Distributions
MathematicsOne of the major issues facing commercial airlines is the time that it takes to board passengers. Further, most airlines wish to increase the number of trips that an aircraft can make between two or more cities.
Srinivas R. Chakravarthy
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Sequential estimation of optimal age replacement policies when distribution of lifetimes is phase type. [PDF]
, 1992 Optimal age replacement policies are designed to cut down system failures and minimize maintenance cost. By scheduling planned replacements, a system is replaced at age * or at failure, whichever comes first, and the cost of replacement before failure ...
Pumpiched, Patchara
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
The Effect of He on the Evolution of Radiation-Induced Dislocation Loops near W/Cu Interface
MetalsIn the current work, the distribution behaviors of irradiation-induced dislocation loops near the W-Cu interface (contains a thin W2C transition layer) under self-interstitial atom diffusion-dominated conditions were investigated based on the comparative
Huaqing Sang, Yifan Zhang, Jing Wang
doaj +1 more source
A continuous multivariate exponential distribution that is multivariate phase type
A reliability model for a bivariate exponential distribution is extended to the multivariate case. The multivariate exponential distribution is then shown to be of multivariate phase type (MPH), and its MPH representation is derived.Markov chains ...
O'Cinneide, Colm A., Raftery, Adrian E.
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source