Results 121 to 130 of about 15,413,531 (300)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The number of individuals alive in a branching process given only times of deaths [PDF]
The study of many population growth models is complicated by only partial observation of the underlying stochastic process driving the model. For example, in an epidemic outbreak we might know when individuals show symptoms to a disease and are removed ...
Ball, Frank, Neal, Peter
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Quantitative and Qualitative Analysis of Aircraft Round-Trip Times Using Phase Type Distributions
MathematicsOne of the major issues facing commercial airlines is the time that it takes to board passengers. Further, most airlines wish to increase the number of trips that an aircraft can make between two or more cities.
Srinivas R. Chakravarthy
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A two-stage approach to the joint analysis of longitudinal and survival data utilising the Coxian phase-type distribution. [PDF]
Stat Methods Med Res, 2018 Donnelly C +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The Effect of He on the Evolution of Radiation-Induced Dislocation Loops near W/Cu Interface
MetalsIn the current work, the distribution behaviors of irradiation-induced dislocation loops near the W-Cu interface (contains a thin W2C transition layer) under self-interstitial atom diffusion-dominated conditions were investigated based on the comparative
Huaqing Sang, Yifan Zhang, Jing Wang
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Nakagami-M Phase-Envelope Joint
, 2008 Introduction: When the Nakagami-m envelope distribution was proposed [1], no information on the phase distribution of the corresponding signal was provided.
Distribution Yacoub Fraidenraich
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source