Results 101 to 110 of about 1,736,707 (316)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Phase-Type Distributions and Majorization

The Annals of Applied Probability, 1991
Aldous and Shepp recently proved that the Erlang distribution of a given order is the least variable phase-type distribution of that order, in the sense of minimizing the coefficient of variation. Here we prove that it is also least variable in the sense of majorization.
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

General analysis of type I second-harmonic generation with elliptical Gaussian beams

, 1997
One can enhance second-harmonic generation in angle-tuned crystals by focusing the fundamental to an elliptical waist in the crystal. We present a general analysis for type I phase-matched uniaxial and biaxial crystals that will find particular ...
Walz, Jochen, Leibfried, Dietrich, Freegarde, Tim, Coutts, Julian, Hansch, T.W.   +4 more
core  

Approximation of Cumulative Distribution Functions by Bernstein Phase-Type Distributions

Performance Evaluation
The inclusion of generally distributed random variables in stochastic models is often tackled by choosing a parametric family of distributions and applying fitting algorithms to find appropriate parameters. A recent paper proposed the approximation of probability density functions (PDFs) by Bernstein exponentials, which are obtained from Bernstein ...
András Horváth, Illés Horváth, Marco Paolieri, Miklós Telek, Enrico Vicario   +4 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Analysis of a queuing system of a single capacity with phase-type distributions and queue updating

Discrete and Continuous Models and Applied Computational Science
In this paper, we study a queuing system with a single-capacity storage device and queue updating. An update is understood as the following mechanism: an application that enters the system and finds another application in the drive destroys it, taking ...
Sergey I. Matyushenko, Konstantin E. Samouylov, Nikolai Yu. Gritsenko   +2 more
doaj   +1 more source

Equilibrium distributions of discrete phase type [PDF]

, 2013
It is well known that the family of discrete phase-type distributions is closed under convolutions, mixtures, and the unary “geometric mixture” operation. In this article, we show that the equilibrium distributions of this family are again of phase type.
Wu, X
core   +1 more source

Sequence Discrimination Using Phase-Type Distributions [PDF]

, 2006
We propose in this paper a novel approach to the classification of discrete sequences. This approach builds a model fitting some dynamical features deduced from the learning sample. These features are discrete phase-type (PH) distributions. They model the first passage times (FPT) between occurrences of pairs of substrings.
Jérôme Callut, Pierre Dupont
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source