Results 81 to 90 of about 1,736,707 (316)

DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s-phase alkylation damage response in S. pombe [PDF]

, 2012
Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching ...
Koulintchenko Milana, Koulintchenko, Milana, Milana Koulintchenko, Sonya Vengrova, Vengrova S., Dalgaard Jacob Z., Trevor Eydmann, Prakash Arumugam, Eydmann Trevor, Koulintchenko M., Arumugam P., Vengrova, Sonya, Arumugam Prakash, Jacob Z. Dalgaard, Arumugam, Prakash, Eydmann T., Eydmann, Trevor, Dalgaard, Jacob Z., Jacob Z Dalgaard, Dalgaard J.Z., Vengrova Sonya   +20 more
core   +1 more source

Simulating Coxian phase‐type distributions for patient survival [PDF]

International Transactions in Operational Research, 2009
AbstractCoxian phase‐type distributions are a special type of Markov model that can be used to represent survival times in terms of phases through which an individual may progress until they eventually leave the system completely. Previous research has considered the Coxian phase‐type distribution to be ideal in representing patient survival in ...
Marshall, A, ZENGA, MARIANGELA
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Classification and properties of acyclic discrete phase-type distributions based on geometric and shifted geometric distributions

Journal of Industrial Engineering International, 2018
Acyclic phase-type distributions form a versatile model, serving as approximations to many probability distributions in various circumstances. They exhibit special properties and characteristics that usually make their applications attractive.
Mohsen Varmazyar, Raha Akhavan-Tabatabaei, Nasser Salmasi, Mohammad Modarres   +3 more
doaj   +1 more source

Turbulent bubbly flow in pipe under gravity and microgravity conditions [PDF]

, 2012
Experiments on vertical turbulent flow with millimetric bubbles, under three gravity conditions, upward, downward and microgravity flows (1g, -1g and 0g), have been performed to understand the influence of gravity upon the flow structure and the phase ...
Colin, Catherine, Fabre, Jean, Kamp, Arjan   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Countercurrent chromatography of proteins using aqueous two-phase systems

, 2008
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The biotechnology industry requires high - capacity protein manufacturing processes that retain protein functionality.
Bourton, Emma Catherine
core  

A note on characterizing service interruptions with phase type distribution

, 2013
In this article, we model an interrupted service scheme that has applications in practice using phase-type distribution. Services are subject to interruptions that occur according to a Poisson process.
Pramod, Padinhare K,, Krishnamoorthy, Achyutha, Chakravarthy, Srinivas R.   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Finite time ruin probabilities with one Laplace inversion. [PDF]

In this work we present an explicit formula for the Laplace transform in time of the finite time ruin probabilities of a classical Levy model with phase-type claims. Our result generalizes the ultimate ruin probability formula of Asmussen and Rolski [IME
Avram, Florin, Usábel, Miguel A.
core