Results 91 to 100 of about 15,413,531 (300)

The least variable phase type distribution is erlang

open access: yesCommunications in Statistics. Stochastic Models, 1987
Let \((X_ t,t\geq 0)\) be a continuous-time Markov process with state space \(\{\) 0,1,...,n\(\}\) where 0 is an absorbing state, and let \(T_{n0}\) denote the time to reach 0 if \(X_ 0=n\). It is shown that \(var(T_{n0})/(E T_{n0})\) \(2\geq 1/n\) with equality if and only if \((X_ t,t\geq 0)\) is a pure death process with constant death rate.
David, Aldous, Larry, Shepp
openaire   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Finite time ruin probabilities with one Laplace inversion. [PDF]

open access: yes
In this work we present an explicit formula for the Laplace transform in time of the finite time ruin probabilities of a classical Levy model with phase-type claims. Our result generalizes the ultimate ruin probability formula of Asmussen and Rolski [IME
Avram, Florin, Usábel, Miguel A.
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

An investigation of emerin and nuclear lamins: : Interactions, distribution, and role in cell cycle regulation, in cells derived from EDMD patients. [PDF]

open access: yes, 2002
Emery Dreifuss muscular dystrophy (EDMD) is caused by mutations either in the gene encoding emerin or in the gene encoding A-type lamins (lamins A and C).
Maria, Choleza
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Information matrix test An application using Pareto’s original income distribution data

open access: yes, 2010
This article attempts to apply and interpret the correspondent Identification Matrix test (White, 1982) for a Pareto type I distribution. One of the most cited datasets used by Pareto, England’s income distribution in 1843 and in 1879, is used.
Mattos, Enlinson, Ponczek, Vladimir
core  

Three-phase fast decoupled power flow for distribution networks

open access: yes, 2015
Power system single-phase models assume that generation, transmission and distribution systems are perfectly balanced. The great appeal of this type of model is its simplicity, for all the calculations become quite simple, when compared with the three ...
Zago, MG, Garcia, AV
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Many-server queues with customer abandonment: Numerical analysis of their diffusion model

open access: yesStochastic Systems, 2013
We use a multidimensional diffusion process to approximate the dynamics of aqueue served by many parallel servers. Waiting customers in this queue may abandonthe system without service.
Shuangchi He, Jim Dai
doaj  

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